The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Phlebotomy


Psychiatry related information on Phlebotomy


High impact information on Phlebotomy

  • There is evidence that iron loading and organ damage can be prevented in patients with hemochromatosis if prophylactic phlebotomy is employed early in the disease--findings emphasizing the importance of early detection before clinical signs occur [8].
  • Three treatment regimens were used: phlebotomy alone, chlorambucil supplemented by phlebotomy, or radioactive phosphorus supplemented by phlebotomy [9].
  • His erythropoietin excretion after a 1000-ml phlebotomy increased by 0 to 11 units per day [10].
  • To determine the accuracy of portable cholesterol analyzers in public settings, four screening organizations were accompanied to cholesterol screenings where consenting participants completed the finger-stick procedure and provided a blood sample by venipuncture [11].
  • Six separate 5-d courses of hydroxyurea at 100 mg/kg per d were then administered over the next 200 d while phlebotomy was continued [12].

Chemical compound and disease context of Phlebotomy


Biological context of Phlebotomy


Anatomical context of Phlebotomy


Associations of Phlebotomy with chemical compounds

  • However, the risk of acute leukemia in patients given chlorambucil was 2.3 times that in patients given radioactive phosphorus and 13 times that in patients treated with phlebotomy alone [9].
  • So that this inverse association could be retested, retinol determinations were performed on sera in 135 incident cancer cases, identified during a vital status follow-up in 1981, and in 237 controls matched by race, sex, age, and date of venipuncture [28].
  • INTERVENTIONS: Patients were randomly assigned to receive skin preparation with an aqueous solution of 10% povidone-iodine or an alcoholic solution of 0.5% chlorhexidine before phlebotomy [29].
  • Venous samples were obtained serially from 18 chronic schizophrenics and nine controls before and after the intravenous administration of protirelin and gonadorelin (gonadotropin releasing hormone [GnRH] ) and by venipuncture from 38 controls [30].
  • By contrast, 11-dehydro-TXB2 did not change significantly in the sequential catheter samples or in the samples drawn by separate venipuncture [31].

Gene context of Phlebotomy

  • CONCLUSIONS: The sensitivity of the phenotypic tests in decreasing order was as follows: serum ferritin, hepatic iron index, transferrin saturation, and iron removed by venesection [18].
  • DMT1 expression was significantly increased in HH patients who had undergone phlebotomy therapy (treated) and in patients with ID compared with controls [32].
  • Following venesection, MMP-2 and MMP-3 concentrations increased by 11% (p = 0.03) and 19% (p = 0.03), respectively [33].
  • CONCLUSIONS: These findings demonstrate that untreated HH patients do not have increased duodenal DMT1 and IREG mRNA, but rather phlebotomy increases expression of these molecules, reflecting the effect of phlebotomy induced erythropoiesis [32].
  • In subjects with HH on maintenance phlebotomy treatment, blood concentrations of cadmium, but not lead, were significantly higher than in paired controls [34].

Analytical, diagnostic and therapeutic context of Phlebotomy


  1. Nosocomial pseudobacteremia. Positive blood cultures due to contaminated benzalkonium antiseptic. Kaslow, R.A., Mackel, D.C., Mallison, G.F. JAMA (1976) [Pubmed]
  2. Stimulation of erythropoietic differentiation in BALB/c mice infected with Rauscher leukemia virus. Weitz-Hamburger, A., Fredrickson, T.N., LoBue, J., Hardy, W.D., Camiscoli, J.F., Ferdinand, P., Gallicchio, V., Gordon, A.S. J. Natl. Cancer Inst. (1975) [Pubmed]
  3. Polycythemia: mechanisms and management. Golde, D.W., Hocking, W.G., Koeffler, H.P., Adamson, J.W. Ann. Intern. Med. (1981) [Pubmed]
  4. Hypogonadism in hemochromatosis: reversal with iron depletion. Kelly, T.M., Edwards, C.Q., Meikle, A.W., Kushner, J.P. Ann. Intern. Med. (1984) [Pubmed]
  5. Four new mutations in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene causing X-linked sideroblastic anemia: increased pyridoxine responsiveness after removal of iron overload by phlebotomy and coinheritance of hereditary hemochromatosis. Cotter, P.D., May, A., Li, L., Al-Sabah, A.I., Fitzsimons, E.J., Cazzola, M., Bishop, D.F. Blood (1999) [Pubmed]
  6. Bone and joint involvement in genetic hemochromatosis: role of cirrhosis and iron overload. Sinigaglia, L., Fargion, S., Fracanzani, A.L., Binelli, L., Battafarano, N., Varenna, M., Piperno, A., Fiorelli, G. J. Rheumatol. (1997) [Pubmed]
  7. Recurrent asystole associated with vasovagal reaction during venipuncture. Lipton, J.D., Forstater, A.T. The Journal of emergency medicine. (1993) [Pubmed]
  8. Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. Edwards, C.Q., Griffen, L.M., Goldgar, D., Drummond, C., Skolnick, M.H., Kushner, J.P. N. Engl. J. Med. (1988) [Pubmed]
  9. Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy. Berk, P.D., Goldberg, J.D., Silverstein, M.N., Weinfeld, A., Donovan, P.B., Ellis, J.T., Landaw, S.A., Laszlo, J., Najean, Y., Pisciotta, A.V., Wasserman, L.R. N. Engl. J. Med. (1981) [Pubmed]
  10. Erythropoiesis in familial erythrocytosis. Greenberg, B.R., Golde, D.W. N. Engl. J. Med. (1977) [Pubmed]
  11. The accuracy of portable cholesterol analyzers in public screening programs. Naughton, M.J., Luepker, R.V., Strickland, D. JAMA (1990) [Pubmed]
  12. Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis. Letvin, N.L., Linch, D.C., Beardsley, G.P., McIntyre, K.W., Miller, B.A., Nathan, D.G. J. Clin. Invest. (1985) [Pubmed]
  13. Nontransferrin-bound iron in plasma from hemochromatosis patients: effect of phlebotomy therapy. Aruoma, O.I., Bomford, A., Polson, R.J., Halliwell, B. Blood (1988) [Pubmed]
  14. Normalization of elevated hepatic 8-hydroxy-2'-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet. Kato, J., Kobune, M., Nakamura, T., Kuroiwa, G., Takada, K., Takimoto, R., Sato, Y., Fujikawa, K., Takahashi, M., Takayama, T., Ikeda, T., Niitsu, Y. Cancer Res. (2001) [Pubmed]
  15. Total serum glycosylated proteins in detection and monitoring of gestational diabetes. Cefalu, W.T., Prather, K.L., Chester, D.L., Wheeler, C.J., Biswas, M., Pernoll, M.L. Diabetes Care (1990) [Pubmed]
  16. Changes in the expression of the heme-regulated eIF-2 alpha kinase and heat shock proteins in rabbit reticulocytes maturing during recovery from anemia. Uma, S., Barret, D.J., Matts, R.L. Exp. Cell Res. (1998) [Pubmed]
  17. Imatinib mesylate (Gleevec(TM)) reduces phlebotomy requirements in polycythemia vera. Silver, R.T. Leukemia (2003) [Pubmed]
  18. Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria. Adams, P.C., Chakrabarti, S. Gastroenterology (1998) [Pubmed]
  19. Erythropoietin kinetics in rats: generation and clearance. Steinberg, S.E., Garcia, J.F., Matzke, G.R., Mladenovic, J. Blood (1986) [Pubmed]
  20. Dysregulated expression of GATA-1 following retrovirus-mediated gene transfer into murine hematopoietic stem cells increases erythropoiesis. Farina, S.F., Girard, L.J., Vanin, E.F., Nienhuis, A.W., Bodine, D.M. Blood (1995) [Pubmed]
  21. Erythropoietin-dependent primary pure erythrocytosis. Dainiak, N., Hoffman, R., Lebowitz, A.I., Solomon, L., Maffei, L., Ritchey, K. Blood (1979) [Pubmed]
  22. The ancestral hemochromatosis haplotype is associated with a severe phenotype expression in Italian patients. Piperno, A., Arosio, C., Fargion, S., Roetto, A., Nicoli, C., Girelli, D., Sbaiz, L., Gasparini, P., Boari, G., Sampietro, M., Camaschella, C. Hepatology (1996) [Pubmed]
  23. Recombinant human erythropoietin for autologous blood donation: effects on perioperative red-blood-cell and serum erythropoietin production. Tasaki, T., Ohto, H., Hashimoto, C., Abe, R., Saitoh, A., Kikuchi, S. Lancet (1992) [Pubmed]
  24. Effect of short-term protein deprivation on hemopoietic functions of healthy volunteers. Catchatourian, R., Eckerling, G., Fried, W. Blood (1980) [Pubmed]
  25. Factor VIII-related protein circulates in normal human plasma as high molecular weight multimers. Hoyer, L.W., Shainoff, J.R. Blood (1980) [Pubmed]
  26. Association of diabetes, serum insulin, and C-peptide with gallbladder disease. Ruhl, C.E., Everhart, J.E. Hepatology (2000) [Pubmed]
  27. Effect of blood collection technique in mice on clinical pathology parameters. Schnell, M.A., Hardy, C., Hawley, M., Propert, K.J., Wilson, J.M. Hum. Gene Ther. (2002) [Pubmed]
  28. Serum retinol and risk of subsequent cancer: extension of the Evans County, Georgia, study. Peleg, I., Heyden, S., Knowles, M., Hames, C.G. J. Natl. Cancer Inst. (1984) [Pubmed]
  29. Chlorhexidine compared with povidone-iodine as skin preparation before blood culture. A randomized, controlled trial. Mimoz, O., Karim, A., Mercat, A., Cosseron, M., Falissard, B., Parker, F., Richard, C., Samii, K., Nordmann, P. Ann. Intern. Med. (1999) [Pubmed]
  30. Anterior pituitary hormone secretion in chronic schizophrenics. Ferrier, I.N., Johnstone, E.C., Crow, T.J., Rincon-Rodriguez, I. Arch. Gen. Psychiatry (1983) [Pubmed]
  31. 11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation. Catella, F., Healy, D., Lawson, J.A., FitzGerald, G.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  32. Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis. Kelleher, T., Ryan, E., Barrett, S., Sweeney, M., Byrnes, V., O'Keane, C., Crowe, J. Gut (2004) [Pubmed]
  33. Evidence for altered hepatic matrix degradation in genetic haemochromatosis. George, D.K., Ramm, G.A., Powell, L.W., Fletcher, L.M., Walker, N.I., Cowley, L.L., Crawford, D.H. Gut (1998) [Pubmed]
  34. Phlebotomy increases cadmium uptake in hemochromatosis. Akesson, A., Stål, P., Vahter, M. Environ. Health Perspect. (2000) [Pubmed]
  35. Multicyclic, dose-intensive chemotherapy supported by sequential reinfusion of hematopoietic progenitors in whole blood. Pettengell, R., Woll, P.J., Thatcher, N., Dexter, T.M., Testa, N.G. J. Clin. Oncol. (1995) [Pubmed]
  36. Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. Gaenzer, H., Marschang, P., Sturm, W., Neumayr, G., Vogel, W., Patsch, J., Weiss, G. J. Am. Coll. Cardiol. (2002) [Pubmed]
  37. Predictive value of airways hyperresponsiveness and circulating IgE for identifying types of responses to toluene diisocyanate inhalation challenge. Karol, M.H., Tollerud, D.J., Campbell, T.P., Fabbri, L., Maestrelli, P., Saetta, M., Mapp, C.E. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  38. Hemodilution improves cerebral hemodynamics in internal carotid artery occlusion. Yamauchi, H., Fukuyama, H., Ogawa, M., Ouchi, Y., Kimura, J. Stroke (1993) [Pubmed]
  39. Phenotypic analysis of alveolar macrophages and monocytes in allergic airway inflammation. I. Evidence for activation of alveolar macrophages, but not peripheral blood monocytes, in subjects with allergic rhinitis and asthma. Viksman, M.Y., Liu, M.C., Bickel, C.A., Schleimer, R.P., Bochner, B.S. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
WikiGenes - Universities