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Chemical Compound Review

Etarotene     6-[(E)-1-(4- ethylsulfonylphenyl)prop-1- en...

Synonyms: Etaroteno, Etarotenum, CHEMBL549872, SureCN636235, CCRIS 5451, ...
 
 
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Disease relevance of Etarotene

 

High impact information on Etarotene

 

Biological context of Etarotene

  • All tested compounds but one (Ro 15-1570) revealed a dose-dependent inhibition of RNase P activity, indicating that they may have a direct effect on tRNA biogenesis [3].
 

Associations of Etarotene with other chemical compounds

References

  1. Comparative teratogenicity of three retinoids: the arotinoids Ro 13-7410, Ro 13-6298 and Ro 15-1570. Kistler, A., Galli, B., Howard, W.B. Arch. Toxicol. (1990) [Pubmed]
  2. Regulation of the induction of ornithine decarboxylase in keratinocytes by retinoids. Zheng, Z.S., Xue, G.Z., Prystowsky, J.H. Biochem. J. (1995) [Pubmed]
  3. Retinoids inhibit human epidermal keratinocyte RNase P activity. Papadimou, E., Pavlidou, D., Séraphin, B., Tsambaos, D., Drainas, D. Biol. Chem. (2003) [Pubmed]
  4. Effects of retinoids and hydrocortisone on keratinocyte differentiation, epidermal growth factor binding and lipid metabolism. Ponec, M., Boonstra, J. Dermatologica (1987) [Pubmed]
 
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