The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

TTNPB     4-[(E)-2-(5,5,8,8- tetramethyl-6,7...

Synonyms: Lopac-T-3757, Arotinoic acid, Arotinoid acid, Tocris-0761, AC1NRDEA, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Arotinoid acid


High impact information on Arotinoid acid


Biological context of Arotinoid acid


Gene context of Arotinoid acid

  • RAR alpha and RAR beta showed similar levels of activation with all the retinoids tested, Ro 12-4894 and Ro 13-7410 induced little transcription in the presence of RAR gamma [11].


  1. Effects of arotinoids upon murine embryonal carcinoma cells. Sherman, M.I., Paternoster, M.L., Taketo, M. Cancer Res. (1983) [Pubmed]
  2. Anetodermic prurigo nodularis (with Pautrier's neuroma) responsive to arotinoid acid. Hirschel-Scholz, S., Salomon, D., Merot, Y., Saurat, J.H. J. Am. Acad. Dermatol. (1991) [Pubmed]
  3. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Pignatello, M.A., Kauffman, F.C., Levin, A.A. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  4. The effects of retinoid treatment and antiestrogens on the growth of T47D human breast cancer cells. Wetherall, N.T., Taylor, C.M. European journal of cancer & clinical oncology. (1986) [Pubmed]
  5. The RAR-RXR as well as the RXR-RXR pathway is involved in signaling growth inhibition of human CD34+ erythroid progenitor cells. Rusten, L.S., Dybedal, I., Blomhoff, H.K., Blomhoff, R., Smeland, E.B., Jacobsen, S.E. Blood (1996) [Pubmed]
  6. Effect of retinoids on hyperproliferation-associated keratins K6 and K16 in cultured human keratinocytes: a quantitative analysis. Korge, B., Stadler, R., Mischke, D. J. Invest. Dermatol. (1990) [Pubmed]
  7. Inhibitory effects of arotinoids on tRNA biogenesis. Papadimou, E., Monastirli, A., Tsambaos, D., Merk, H.F., Drainas, D. Skin Pharmacol. Appl. Skin Physiol. (2000) [Pubmed]
  8. Stimulation by retinoids of tissue-type plasminogen activator secretion in cultured human endothelial cells: relations of structure to effect. Bulens, F., Nelles, L., Van den Panhuyzen, N., Collen, D. J. Cardiovasc. Pharmacol. (1992) [Pubmed]
  9. Retinoids can be classified according to their effects on vitamin A metabolism in HeLa cells. Stenström, E., Björklind, C., Schaaf, B., Vahlquist, A., Törmä, H. Skin Pharmacol. (1996) [Pubmed]
  10. Arotinoid acid (Ro 13-7410): a pilot study in dermatology. Saurat, J.H., Mérot, Y., Borsky, M., Abba, Z., Hirschel-Scholz, S. Dermatologica (1988) [Pubmed]
  11. Transcriptional activation of a model reporter system by retinoids and retinoic acid receptor isoforms. Huggenvik, J.I., Sharma, R.P. Pharmacol. Toxicol. (1995) [Pubmed]
WikiGenes - Universities