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Chemical Compound Review:

CHEMBL22369 ethyl4-[(E)-2-(5,5,8,8- tetramethyl-6,7...

Synonyms: CCRIS 5450, SureCN2890175, AC1O5MYH, LS-38312, Ro-136298, ...

Agarwal, C. et al., Tousignant, J. et al., Bollag, W., Millest, A.J. et al., Zimmermann, B. et al., et al.

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Disease relevance of Arotinoid ethyl ester

In the first study, the ability of ALLN to inhibit bone resorption was investigated in Ro-13-6298 (arotinoid)-treated thyroparathyroidectomized (TPTX) rats [1].
Ro 13-6298 also has a therapeutic influence on chemically induced skin carcinomas in mice [2].
Treatment of cutaneous T-cell lymphoma with the arotinoid Ro 13-6298 [3].
Arotinoid Ro 13-6298 in minute quantities leads to regression of chemically induced papillomas of the skin of mice [2].
The present study describes a case of mycosis fungoides, limited to the skin, which was successfully controlled with the arotinoid Ro 13-6298 [3].

High impact information on Arotinoid ethyl ester

13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production [4].
As Ro 13-6298 binds poorly to the retinoic acid receptors, this suggests that SCC-13 cells, unlike normal keratinocytes, lack the ability to convert Ro 13-6298 to the active Ro 13-7410.(ABSTRACT TRUNCATED AT 250 WORDS)[5]
Arotinoid ethyl ester (Ro 13-6298): a long term pilot study in various dermatoses [6].
In preliminary clinical trials, a new retinoid, Arotinoid Ro 13-6298, was found highly effective in hyperproliferation and keratotic disorders [7].
Therapeutic effect of arotinoid Ro 13-6298 in psoriasis [8].

Biological context of Arotinoid ethyl ester

All-trans-retinoic acid, 13-cis-retinoic acid, and a newly developed arotinoid, RO 13-6298, were tested for their ability to inhibit chondrogenesis [9].

References

Effects of an inhibitor of cathepsin L on bone resorption in thyroparathyroidectomized and ovariectomized rats. Millest, A.J., Breen, S.A., Loveday, B.E., Clarkson, P.N., Simpson, C.A., Waterton, J.C., Johnstone, D. Bone (1997) [Pubmed]
Arotinoids. A new class of retinoids with activities in oncology and dermatology. Bollag, W. Cancer Chemother. Pharmacol. (1981) [Pubmed]
Treatment of cutaneous T-cell lymphoma with the arotinoid Ro 13-6298. Tousignant, J., Raymond, G.P., Light, M.J. J. Am. Acad. Dermatol. (1987) [Pubmed]
Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts. Zitnik, R.J., Kotloff, R.M., Latifpour, J., Zheng, T., Whiting, N.L., Schwalb, J., Elias, J.A. J. Immunol. (1994) [Pubmed]
Retinoid-dependent transcriptional suppression of cytokeratin gene expression in human epidermal squamous cell carcinoma cells. Agarwal, C., Rorke, E.A., Boyce, M., Howard, J., Crish, J., Hufeisen, S., Eckert, R.L. Differentiation (1993) [Pubmed]
Arotinoid ethyl ester (Ro 13-6298): a long term pilot study in various dermatoses. Mérot, Y., Camenzind, M., Geiger, J.M., Saurat, J.H. Acta Derm. Venereol. (1987) [Pubmed]
Effect of a new retinoid, arotinoid (Ro 13-6298), on in vitro keratinocyte proliferation and differentiation. Stadler, R., Marcelo, C.L., Voorhees, J.J., Orfanos, C.E. Acta Derm. Venereol. (1984) [Pubmed]
Therapeutic effect of arotinoid Ro 13-6298 in psoriasis. Ott, F., Geiger, J.M. Arch. Dermatol. Res. (1983) [Pubmed]
Evaluation of the sensitive step of inhibition of chondrogenesis by retinoids in limb mesenchymal cells in vitro. Zimmermann, B., Tsambaos, D. Cell Differ. (1985) [Pubmed]

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