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Chemical Compound Review

CHEMBL458094     (E)-1-[2-hydroxy-4-methoxy-3- (3-methylbut...

Synonyms: SureCN1024850, AC1O5PRS, LMPK12120041, HMS2195D24, MLS000574847, ...
 
 
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Disease relevance of AIDS185984

 

High impact information on AIDS185984

  • These results suggest that the antitumor and antimetastatic activities of 4-hydroxyderricin may be modulated by the immune system and the inhibition of angiogenesis [1].
  • In addition, 4-hydroxyderricin (50 mg/kg x 2/day) inhibited the reduction of the numbers of lymphocytes, CD4+, CD8+ and natural killer (NK)-T cells in the spleen of tumor-removed mice [1].
  • The weights of the spleen and thymus in mice with subcutaneously implanted LLC were maintained close to those of normal mice by orally administered 4-hydroxyderricin [1].
  • 4-Hydroxyderricin inhibited DNA synthesis in LLC cells at a concentration of 100 microM, but it had no effect on the DNA synthesis in human umbilical vein endothelial cells (HUVECs) or on the adherence of LLC cells to HUVECs [1].
  • 1. Recently, we reported that 4-hydroxyderricin, one of the major chalcones in Angelica keiskei extract (ethyl acetate extract from the yellow liquid of stems), exerted hypotensive and lipid regulatory actions in stroke-prone spontaneously hypertensive rats (SHRSP) [3].
 

Chemical compound and disease context of AIDS185984

 

Biological context of AIDS185984

 

Associations of AIDS185984 with other chemical compounds

References

  1. Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots. Kimura, Y., Taniguchi, M., Baba, K. Planta Med. (2004) [Pubmed]
  2. New prenylated chalcones from Lonchocarpus neuroscapha Benth. (Cordoa piaca). Gonçalves de Lima, O., de Méllo, J.F., de Barros Coêlho, J.S., de Andrade Lyra, F.D., Machado de Albuquerque, M., Marini-Bettólo, G.B., Delle Monache, G., Delle Monache, F. Il Farmaco; edizione scientifica. (1975) [Pubmed]
  3. Beneficial effect of xanthoangelol, a chalcone compound from angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats. Ogawa, H., Okada, Y., Kamisako, T., Baba, K. Clin. Exp. Pharmacol. Physiol. (2007) [Pubmed]
  4. Hypotensive and lipid regulatory actions of 4-hydroxyderricin, a chalcone from Angelica keiskei, in stroke-prone spontaneously hypertensive rats. Ogawa, H., Ohno, M., Baba, K. Clin. Exp. Pharmacol. Physiol. (2005) [Pubmed]
 
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