Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL151870 4-[(E)-4-(2,6,6-trimethyl-1...

Synonyms: CHEBI:349304, AC1O5UYK, LS-38539, Agn 190121, 132032-67-8

Standeven, A.M. et al., Standeven, A.M. et al., Kochhar, D.M. et al.

Kochhar, Jiang, Penner, Johnson, Chandraratna,

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Disease relevance of Agn 190121

Hypertriglyceridemia induced by AGN 190121 was significantly inhibited by cotreatment with an RAR-selective antagonist, AGN 193109 [1].

High impact information on Agn 190121

We report that in an in vitro cell differentiation bioassay, AGN 193109 completely reversed the inhibitory action of a potent RAR agonist, AGN 190121 [2].
Histopathological examination of the proximal tibia of AGN 190121-treated guinea pigs revealed a dose-dependent disruption of the epiphyseal plate [3].
Weanling male Hartley guinea pigs were treated ip via osmotic pump for up to 14 days with vehicle or 0.50 to 5.5 mg/kg/day of the retinoic acid receptor (RAR)-selective agonist AGN 190121 [3].
A structural isomer of AGN 190121 that does not activate RARs or RXRs, AGN 190727, did not induce hypertriglyceridemia [1].
Ro 13-6298 and AGN 190121, two RAR-specific agonists, caused dose-dependent increases in serum triglycerides, although Ro 13-6298 only induced hypertriglyceridemia at weight-suppressive doses [1].

References

Retinoid-induced hypertriglyceridemia in rats is mediated by retinoic acid receptors. Standeven, A.M., Beard, R.L., Johnson, A.T., Boehm, M.F., Escobar, M., Heyman, R.A., Chandraratna, R.A. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1996) [Pubmed]
The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events. Kochhar, D.M., Jiang, H., Penner, J.D., Johnson, A.T., Chandraratna, R.A. Int. J. Dev. Biol. (1998) [Pubmed]
Retinoid-induced epiphyseal plate closure in guinea pigs. Standeven, A.M., Davies, P.J., Chandraratna, R.A., Mader, D.R., Johnson, A.T., Thomazy, V.A. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1996) [Pubmed]

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