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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEMBL358145     4-[2-[5,5-dimethyl-8-(4- methylphenyl)-6H...

Synonyms: SureCN346037, CHEBI:339179, AGN193109, CTK8E7401, LS-182384, ...
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Disease relevance of CD 3106

  • We show here that RA, GGOH, GGPP and GGA stimulate osteoclastic bone resorption and that this action is reversed by the RAR antagonist AGN-193109 [1].
  • TTNPB pretreatment caused precipitous weight loss and, in the absence of AGN 193109 intervention, 60% mortality [2].
  • AGN 193109 treatment at all dose levels significantly accelerated recovery of body weight and prevented death in TTNPB-intoxicated mice [2].
  • TTNPB caused skin flaking, skin abrasions, and splenomegaly, and these effects were blocked in a dose-dependent fashion by AGN 193109 cotreatment [2].
  • The purpose of the present study was to determine if AGN 193109 functions as an RAR antagonist in vivo and thus could prevent and/or treat retinoid toxicity [2].

High impact information on CD 3106

  • In contrast, the RAR antagonist AGN 193109 abrogates reconstituting ability, most likely by promoting the differentiation of the primitive stem cells [3].
  • In marked contrast, lin- c-kit+ Sca-1+ cells cultured with AGN 193109 for 7 days had virtually no short- or long-term repopulating ability, but displayed an approximately 6-fold increase in the pre-CFU-S population [3].
  • Furthermore, the ability of 13-cis RA to induce apoptosis cannot be recapitulated by 9-cis RA or ATRA, and it is not inhibited by the presence of a retinoid acid receptor (RAR) pan-antagonist AGN 193109 [4].
  • Inhibition of RA signaling, with the selective inhibitor AGN 193109, blocked RA-mediated induction of the Smad proteins and chondrocyte differentiation [5].
  • The activity of AGN 193109 on MRP-8 is cell type specific [6].

Anatomical context of CD 3106


Gene context of CD 3106

  • This suggests that the AhR/ARNT pathway and not the RAR/RXR pathway is mediating the elevation of CYP1A1 mRNA levels by AGN 193109, at least in the Hepa-1c1c7 cells [7].
  • The synthetic retinoid AGN 193109 is a potent pan retinoic acid receptor (RAR) antagonist [7].
  • TTNPB-induced skin irritation was blocked in a dose-dependent fashion by co-treatment with the RAR pan-antagonist AGN 193109 but was not blocked by co-treatment with the RAR alpha-specific antagonist AGN 194301 [8].


  1. Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. van Beek, E., Löwik, C., Karperien, M., Papapoulos, S. Bone (2006) [Pubmed]
  2. Specific antagonist of retinoid toxicity in mice. Standeven, A.M., Johnson, A.T., Escobar, M., Chandraratna, R.A. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  3. All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells. Purton, L.E., Bernstein, I.D., Collins, S.J. Blood (2000) [Pubmed]
  4. 13-cis Retinoic Acid Induces Apoptosis and Cell Cycle Arrest in Human SEB-1 Sebocytes. Nelson, A.M., Gilliland, K.L., Cong, Z., Thiboutot, D.M. J. Invest. Dermatol. (2006) [Pubmed]
  5. Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. Li, X., Schwarz, E.M., Zuscik, M.J., Rosier, R.N., Ionescu, A.M., Puzas, J.E., Drissi, H., Sheu, T.J., O'Keefe, R.J. Endocrinology (2003) [Pubmed]
  6. Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes. Thacher, S.M., Nagpal, S., Klein, E.S., Arefieg, T., Krasinski, G., DiSepio, D., Agarwal, C., Johnson, A., Eckert, R.L., Chandraratna, R.A. Cell Growth Differ. (1999) [Pubmed]
  7. The synthetic retinoid AGN 193109 but not retinoic acid elevates CYP1A1 levels in mouse embryos and Hepa-1c1c7 cells. Soprano, D.R., Gambone, C.J., Sheikh, S.N., Gabriel, J.L., Chandraratna, R.A., Soprano, K.J., Kochhar, D.M. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  8. Lack of involvement of retinoic acid receptor alpha in retinoid-induced skin irritation in hairless mice. Standeven, A.M., Teng, M., Chandraratna, R.A. Toxicol. Lett. (1997) [Pubmed]
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