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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Pyralene     6H-pyran-2-carbaldehyde

Synonyms: Jsp001585, AC1O5997, 62251-11-0, 2H-pyran-6-carbaldehyde
 
 
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Disease relevance of Pyralene

  • We studied the influence of Pyralene on testicular steroidogenesis and the status of xenobiotic-metabolizing enzymes in the testis and liver of rats during oral exposure (10 and 50 mg/kg body weight, p.o. daily for 1 week) and a 3-week post-treatment recovery period [1].
  • Among changes in the activity, glutathione peroxidase and catalase reflected relatively well the toxicity of Pyralene in these cells [2].
 

High impact information on Pyralene

  • As expected, Pyralene induced a rapid and sustained increase in mRNA transcripts for CYP1A1 and CYP2B1 in hepatocytes that was associated with a dramatic increase in ethoxyresorufin-O-deethylase (EROD) and pentoxyresorufin-O-deethylase (PROD) activities [1].
  • Expression PCR analysis revealed a significant decrease in 17beta-hydroxysteroid dehydrogenase (17betaHSD) transcript abundance at 48 h after Pyralene administration [1].
  • Pyralene markedly decreased in vitro agonist stimulated androgenesis 24 h after bilateral i.t.t.-injection (25 microg/testis), 24 h and 96 h after single i.p.-injection (10 and 50 mg/kg body weight), and 96 h after p.o.-administration (7x10 mg and 7x50 mg/kg body weight daily) [2].
  • Quantitative alterations in the liver and adrenal gland in pregnant rats induced by Pyralene 3000 [3].
  • D-glucose absorption and fluid transfer remained unchanged following doses of other Phenoclor and Pyralene (PCB) compounds [4].

References

  1. Effect of a PCB-based transformer oil on testicular steroidogenesis and xenobiotic-metabolizing enzymes. Andric, N.L., Kostic, T.S., Zoric, S.N., Stanic, B.D., Andric, S.A., Kovacevic, R.Z. Reprod. Toxicol. (2006) [Pubmed]
  2. Parallelism and dissociation in the actions of an Aroclor 1260-based transformer fluid on testicular androgenesis and antioxidant enzymes. Andric, N.L., Andric, S.A., Zoric, S.N., Kostic, T.S., Stojilkovic, S.S., Kovacevic, R.Z. Toxicology (2003) [Pubmed]
  3. Quantitative alterations in the liver and adrenal gland in pregnant rats induced by Pyralene 3000. Vrecl, M., Pogacnik, A., Sek, S., Lorger, J., Bavdek, S. Bulletin of environmental contamination and toxicology. (1995) [Pubmed]
  4. Polychlorinated biphenyls (phenoclor and pyralene) and intestinal transport of hexoses and amino acids in mice. Madge, D.S. Gen. Pharmacol. (1976) [Pubmed]
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