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Gene Review

Cat  -  catalase

Rattus norvegicus

Synonyms: CS1, Cas1, Cat01, Catalase, Catl, ...
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Disease relevance of Cat


Psychiatry related information on Cat


High impact information on Cat


Chemical compound and disease context of Cat


Biological context of Cat


Anatomical context of Cat


Associations of Cat with chemical compounds

  • O2 plus endotoxin increased the concentration and stability of MnSOD, catalase, and GP mRNAs [26].
  • The resistance of HO-1-U937 to hydroperoxides appeared to result from antioxidant properties of bilirubin, an HO-derived product, while that of mHO-1-U937 was ascribable to increased contents of catalase and glutathione [22].
  • However, treatment with captopril resulted in a significant improvement in SOD, GSHPx and catalase activity in the 16-week PMI group [27].
  • Catalase alone was able to increase the resistance of transfected RINm5F insulin-producing tissue culture cells against H(2)O(2) and HX/XO, but no protection was seen in the case of menadione [28].
  • While a TCDD dose of 10 ng/kg/d resulted in significant increases in catalase and GSH-Px activities in Cc and H, doses of 22 and 46 ng/kg/d resulted in dose-dependent suppressions of these two enzymes in the same regions [29].

Physical interactions of Cat


Enzymatic interactions of Cat


Regulatory relationships of Cat


Other interactions of Cat

  • Two of these proteins, heme oxygenase-1 and catalase, were expressed at relatively low levels until approximately the time of birth [37].
  • Regarding changes in the enzyme activities accompanying development of iron epilepsy, the data showed that although SOD and G6P increased by approximately 60% and GR increased by approximately 40%, the increases in the enzyme GP and CA were much lower, less than 20% [38].
  • Ovariectomy increases Na+, K+-ATPase, acetylcholinesterase and catalase in rat hippocampus [39].
  • In terms of enzymatic activity, although we detected lower glutathione S-transferase activity in the crypt epithelium, there was a marginal increase of PHGPX activity, a twofold increase of GSHPx activity, and a three- to fivefold increase of catalase activity in the crypt relative to the distal villus [40].

Analytical, diagnostic and therapeutic context of Cat


  1. Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species. Tiedge, M., Lortz, S., Munday, R., Lenzen, S. Diabetes (1998) [Pubmed]
  2. Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. Chan, S.H., Tai, M.H., Li, C.Y., Chan, J.Y. Free Radic. Biol. Med. (2006) [Pubmed]
  3. Effect of free radical scavengers on diaphragmatic contractility in septic peritonitis. Fujimura, N., Sumita, S., Aimono, M., Masuda, Y., Shichinohe, Y., Narimatsu, E., Namiki, A. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  4. Over-expression of antioxidant enzymes protects cultured hippocampal and cortical neurons from necrotic insults. Wang, H., Cheng, E., Brooke, S., Chang, P., Sapolsky, R. J. Neurochem. (2003) [Pubmed]
  5. Effect of level of dietary protein and total or partial starvation on catalase and superoxide dismutase activity in cardiac and skeletal muscles in young rats. Lammi-Keefe, C.J., Swan, P.B., Hegarty, P.V. J. Nutr. (1984) [Pubmed]
  6. Oxidation of nitric oxide by oxomanganese-salen complexes: a new mechanism for cellular protection by superoxide dismutase/catalase mimetics. Sharpe, M.A., Ollosson, R., Stewart, V.C., Clark, J.B. Biochem. J. (2002) [Pubmed]
  7. Oxidative stress-related parameters in prostate of rats with experimental autoimmune prostatitis. Orsilles, M.A., Depiante-Depaoli, M. Prostate (1998) [Pubmed]
  8. No evidence for oxidative damage in the hippocampus after acute and chronic electroshock in rats. Barichello, T., Bonatto, F., Feier, G., Martins, M.R., Moreira, J.C., Dal-Pizzol, F., Izquierdo, I., Quevedo, J. Brain Res. (2004) [Pubmed]
  9. Effects of 3-amino-1,2,4-triazole on ethanol-induced open-field activity: evidence for brain catalase mediation of ethanol's effects. Aragon, C.M., Spivak, K., Amit, Z. Alcohol. Clin. Exp. Res. (1989) [Pubmed]
  10. Effect of ethanol on nitrite oxidation in the perfused rat liver. Watanabe, M., Takano, T., Nakata, K., Nakamura, K. Food Chem. Toxicol. (1995) [Pubmed]
  11. Cysteine eliminates the feeder cell requirement for cultivation of Trypanosoma brucei bloodstream forms in vitro. Duszenko, M., Ferguson, M.A., Lamont, G.S., Rifkin, M.R., Cross, G.A. J. Exp. Med. (1985) [Pubmed]
  12. Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. Cosentino, F., Patton, S., d'Uscio, L.V., Werner, E.R., Werner-Felmayer, G., Moreau, P., Malinski, T., Lüscher, T.F. J. Clin. Invest. (1998) [Pubmed]
  13. Pertussis toxin treatment alters manganese superoxide dismutase activity in lung. Evidence for lung oxygen toxicity in air-breathing rats. Clerch, L.B., Neithardt, G., Spencer, U., Melendez, J.A., Massaro, G.D., Massaro, D. J. Clin. Invest. (1994) [Pubmed]
  14. Effects of inorganic iron and myoglobin on in vitro proximal tubular lipid peroxidation and cytotoxicity. Zager, R.A., Foerder, C.A. J. Clin. Invest. (1992) [Pubmed]
  15. Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain. Zhang, J., Piantadosi, C.A. J. Clin. Invest. (1992) [Pubmed]
  16. Liver microsomal parameters related to oxidative stress and antioxidant systems in hyperthyroid rats subjected to acute lindane treatment. Simon Giavarotti, K.A., Rodrigues, L., Rodrigues, T., Junqueira, V.B., Videla, L.A. Free Radic. Res. (1998) [Pubmed]
  17. Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung. Archer, S.L., Peterson, D., Nelson, D.P., DeMaster, E.G., Kelly, B., Eaton, J.W., Weir, E.K. J. Appl. Physiol. (1989) [Pubmed]
  18. Antioxidative state of the myocardium and kidneys in acute diabetic rats. Volkovová, K., Chorváthová, V., Jurcovicová, M., Koszeghyová, L., Bobek, P. Physiological research / Academia Scientiarum Bohemoslovaca. (1993) [Pubmed]
  19. Effect of aminoguanidine on erythrocyte lipid peroxidation and activities of antioxidant enzymes in experimental diabetes. Kedziora-Kornatowska, K.Z., Luciak, M., Blaszczyk, J., Pawlak, W. Clin. Chem. Lab. Med. (1998) [Pubmed]
  20. Gene expression of antioxidant enzymes in experimental diabetic neuropathy. Kishi, Y., Nickander, K.K., Schmelzer, J.D., Low, P.A. J. Peripher. Nerv. Syst. (2000) [Pubmed]
  21. Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver catalase. Furuta, S., Hayashi, H., Hijikata, M., Miyazawa, S., Osumi, T., Hashimoto, T. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  22. Gene transfection of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity. Hori, R., Kashiba, M., Toma, T., Yachie, A., Goda, N., Makino, N., Soejima, A., Nagasawa, T., Nakabayashi, K., Suematsu, M. J. Biol. Chem. (2002) [Pubmed]
  23. Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter. Girnun, G.D., Domann, F.E., Moore, S.A., Robbins, M.E. Mol. Endocrinol. (2002) [Pubmed]
  24. Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment. Wohaieb, S.A., Godin, D.V. Diabetes (1987) [Pubmed]
  25. Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats. Cand, F., Verdetti, J. Free Radic. Biol. Med. (1989) [Pubmed]
  26. Tolerance of rats to hyperoxia. Lung antioxidant enzyme gene expression. Clerch, L.B., Massaro, D. J. Clin. Invest. (1993) [Pubmed]
  27. Effects of afterload-reducing drugs on pathogenesis of antioxidant changes and congestive heart failure in rats. Khaper, N., Singal, P.K. J. Am. Coll. Cardiol. (1997) [Pubmed]
  28. Sequential inactivation of reactive oxygen species by combined overexpression of SOD isoforms and catalase in insulin-producing cells. Lortz, S., Tiedge, M. Free Radic. Biol. Med. (2003) [Pubmed]
  29. The role of antioxidant enzymes in TCDD-induced oxidative stress in various brain regions of rats after subchronic exposure. Hassoun, E.A., Al-Ghafri, M., Abushaban, A. Free Radic. Biol. Med. (2003) [Pubmed]
  30. Implanted NGF-producing fibroblasts induce catalase and modify ATP levels but do not affect glutamate receptor binding or NMDA receptor expression in the rat striatum. Frim, D.M., Wüllner, U., Beal, M.F., Isacson, O. Exp. Neurol. (1994) [Pubmed]
  31. Effects of superoxide dismutase and catalase during reduction of adrenochrome by DT-diaphorase and NADPH-cytochrome P450 reductase. Baez, S., Segura-Aguilar, J. Biochem. Mol. Med. (1995) [Pubmed]
  32. Increased spontaneous chemiluminescence from liver homogenates and isolated hepatocytes upon inhibition of O2- and H2O2 utilization. Turrens, J.F., Giulivi, C., Boveris, A. Journal of free radicals in biology & medicine. (1986) [Pubmed]
  33. Antioxidant defense mechanisms in cultured pleural mesothelial cells. Kinnula, V.L., Everitt, J.I., Mangum, J.B., Chang, L.Y., Crapo, J.D. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  34. Effect of N-benzyl-D-glucamine dithiocarbamate on lipid peroxidation in testes of rats treated with cadmium. Kojima, S., Ishihara, N., Hirukawa, H., Kiyozumi, M. Res. Commun. Chem. Pathol. Pharmacol. (1990) [Pubmed]
  35. Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3',5'-monophosphate formation. Mittal, C.K., Murad, F. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  36. Cytokine-induced expression of tPA is differentially modulated by NO and ROS in rat mesangial cells. Eberhardt, W., Beck, K.F., Pfeilschifter, J. Kidney Int. (2002) [Pubmed]
  37. Expression of antioxidant protective proteins in the rat retina during prenatal and postnatal development. Chen, W., Hunt, D.M., Lu, H., Hunt, R.C. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  38. Lipid peroxidation and glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, and glucose-6-phosphate dehydrogenase activities in FeCl3-induced epileptogenic foci in the rat brain. Singh, R., Pathak, D.N. Epilepsia (1990) [Pubmed]
  39. Ovariectomy increases Na+, K+-ATPase, acetylcholinesterase and catalase in rat hippocampus. Monteiro, S.C., Matté, C., Delwing, D., Wyse, A.T. Mol. Cell. Endocrinol. (2005) [Pubmed]
  40. The expression of an intestinal form of glutathione peroxidase (GSHPx-GI) in rat intestinal epithelium. Chu, F.F., Esworthy, R.S. Arch. Biochem. Biophys. (1995) [Pubmed]
  41. Astrocytes enhance radical defence in capillary endothelial cells constituting the blood-brain barrier. Schroeter, M.L., Mertsch, K., Giese, H., Müller, S., Sporbert, A., Hickel, B., Blasig, I.E. FEBS Lett. (1999) [Pubmed]
  42. Lipid peroxidation and free radical scavengers in thyroid dysfunction in the rat: a possible mechanism of injury to heart and skeletal muscle in hyperthyroidism. Asayama, K., Dobashi, K., Hayashibe, H., Megata, Y., Kato, K. Endocrinology (1987) [Pubmed]
  43. Relationship between severity of ischemia and oxidant scavenger enzyme activities in the isolated rat heart. Coudray, C., Boucher, F., Pucheu, S., De Leiris, J., Favier, A. Int. J. Biochem. Cell Biol. (1995) [Pubmed]
  44. Inhibition of bleomycin-induced pulmonary fibrosis by lipopolysaccharide. Phan, S.H., Fantone, J.C. Lab. Invest. (1984) [Pubmed]
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