The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEMBL347534     methyl2-(6-amino-3-imino- xanthen-9...

Synonyms: SureCN268381, CHEBI:355382, AC1Q5ZQN, PDSP1_000346, PDSP2_000344, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Rhodamine 123

  • Combination of the two agents, CDDP+caffeine, strongly suppressed not only cell viability but also R123 uptake and cell size, compared with CDDP pretreatment alone [1].
  • Cell cycle arrest in G2 + M phase and a concomitant increase in both rhodamine 123 (R123) uptake and cell size (forward scatter) were observed in these cells [1].
  • Binding to mitochondria was temperature-dependent and the degree of binding was in the order of TMRE > R123 > TMRM [2].
  • A direct concentration-effect relationship between zosuquidar.3HCl concentrations and inhibition of rhodamine 123 (Rh123) efflux in CD56 lymphocytes was defined by a sigmoid E(max) model [3].
  • In contrast, the strongest R123 fluorescence signal is detected in the intracellular cytoplasm of the viable epidermal keratinocytes [4].

Biological context of Rhodamine 123

  • In the AUC method, two samples with identical R123 brightness or percentage below cutoff after dye efflux can have very different total activities, depending on their basal activity [5].

Anatomical context of Rhodamine 123

  • By using rhodamine 123 (Rh123) monitored by flow cytometry in living hepatocytes, we were able to follow in time delta psi in such DNP-uncoupled cells incubated with various substrates [6].
  • Intracellular oxidation of dihydrorhodamine 123 (DHR) to the fluorescent compound rhodamine 123 (Rho123) was used to detect the production of oxygen metabolites in activated neutrophils [7].

Gene context of Rhodamine 123

  • P-gp activity can be detected by measuring efflux of fluorescent substrates such as rhodamine 123 (R123) [5].


  1. Enhancement of CDDP cytotoxicity by caffeine is characterized by apoptotic cell death. Shinomiya, N., Shinomiya, M., Wakiyama, H., Katsura, Y., Rokutanda, M. Exp. Cell Res. (1994) [Pubmed]
  2. Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Scaduto, R.C., Grotyohann, L.W. Biophys. J. (1999) [Pubmed]
  3. Population pharmacokinetic model for daunorubicin and daunorubicinol coadministered with zosuquidar.3HCl (LY335979). Callies, S., de Alwis, D.P., Mehta, A., Burgess, M., Aarons, L. Cancer Chemother. Pharmacol. (2004) [Pubmed]
  4. Observation and quantification of ultraviolet-induced reactive oxygen species in ex vivo human skin. Hanson, K.M., Clegg, R.M. Photochem. Photobiol. (2002) [Pubmed]
  5. Measurement of basal, substrate induced and total P-glycoprotein activity in bronchoalveolar lavage T-cell subsets. Donnenberg, V.S., Wilson, J.W., Burckart, G.J., Zeevi, A., Iacono, A., Donnenberg, A.D. Cytometry. Part A : the journal of the International Society for Analytical Cytology. (2004) [Pubmed]
  6. 2,4 Dinitrophenol-uncoupling effect on delta psi in living hepatocytes depends on reducing-equivalent supply. Sibille, B., Ronot, X., Filippi, C., Nogueira, V., Keriel, C., Leverve, X. Cytometry. (1998) [Pubmed]
  7. Limitations on the use of dihydrorhodamine 123 for flow cytometric analysis of the neutrophil respiratory burst. van Pelt, L.J., van Zwieten, R., Weening, R.S., Roos, D., Verhoeven, A.J., Bolscher, B.G. J. Immunol. Methods (1996) [Pubmed]
WikiGenes - Universities