The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

SureCN3682802     methyl 2-(3,6-diamino-9H-xanthen-9...

Synonyms: D1054_SIAL, AC1L2XWZ, ZINC04521394, AKOS015894985, FT-0624967, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dihydrorhodamine 123


Psychiatry related information on Dihydrorhodamine 123


High impact information on Dihydrorhodamine 123


Chemical compound and disease context of Dihydrorhodamine 123


Biological context of Dihydrorhodamine 123


Anatomical context of Dihydrorhodamine 123


Associations of Dihydrorhodamine 123 with other chemical compounds


Gene context of Dihydrorhodamine 123

  • Intracellular peroxidation was studied in activated T cells by dihydrorhodamine 123 fluorescence analysis of cells treated with COX-2 antisense or control oligonucleotides [31].
  • Superoxide production assayed by both cytochrome c reduction and oxidation of dihydrorhodamine 123, was induced by heterologous polyclonal anti-MPO and anti-LF antibodies, and ANCA-positive plasma samples [32].
  • With antigen-challenged animals the protein kinase C (PKC) activator, PMA, significantly increased intracellular ROS of circulating neutrophils, as determined by flow cytometry using the fluorescent probe dihydrorhodamine-123 [33].
  • Tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 concentrations were measured in portal and systemic serum, and in the perfusate 30 and 90 min after the 'second hit'. Neutrophil activation by the perfusate was assayed using dihydrorhodamine-123 fluorescence [34].
  • In order to elucidate the components of the oxygen sensory complex in HepG2 cells which regulates the production of erythropoietin, we have microinjected recombinant variants of the human small GTP-binding protein hRac1 and measured their effects on the production of reactive oxygen species (ROS) by the dihydrorhodamine-123 technique [35].

Analytical, diagnostic and therapeutic context of Dihydrorhodamine 123


  1. Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. Yamane, Y., Furuichi, M., Song, R., Van, N.T., Mulcahy, R.T., Ishikawa, T., Kuo, M.T. J. Biol. Chem. (1998) [Pubmed]
  2. Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay. Jirapongsananuruk, O., Malech, H.L., Kuhns, D.B., Niemela, J.E., Brown, M.R., Anderson-Cohen, M., Fleisher, T.A. J. Allergy Clin. Immunol. (2003) [Pubmed]
  3. Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress. Rego, A.C., Santos, M.S., Oliveira, C.R. Free Radic. Biol. Med. (1999) [Pubmed]
  4. Oxygen and glucose deprivation induces mitochondrial dysfunction and oxidative stress in neurones but not in astrocytes in primary culture. Almeida, A., Delgado-Esteban, M., Bolaños, J.P., Medina, J.M. J. Neurochem. (2002) [Pubmed]
  5. Neutrophil respiratory burst in term and preterm neonates without signs of infection and in those with increased levels of C-reactive protein. Gessler, P., Nebe, T., Birle, A., Haas, N., Kachel, W. Pediatr. Res. (1996) [Pubmed]
  6. Free radical production and changes in superoxide dismutases associated with hypoxia/reoxygenation-induced apoptosis of embryonic rat forebrain neurons in culture. Lièvre, V., Becuwe, P., Bianchi, A., Koziel, V., Franck, P., Schroeder, H., Nabet, P., Dauça, M., Daval, J.L. Free Radic. Biol. Med. (2000) [Pubmed]
  7. The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis. Fossati, G., Moulding, D.A., Spiller, D.G., Moots, R.J., White, M.R., Edwards, S.W. J. Immunol. (2003) [Pubmed]
  8. Divergence of mechanisms regulating respiratory burst in blood and sputum eosinophils and neutrophils from atopic subjects. Lacy, P., Abdel-Latif, D., Steward, M., Musat-Marcu, S., Man, S.F., Moqbel, R. J. Immunol. (2003) [Pubmed]
  9. Mycobacterium tuberculosis 19-kDa lipoprotein promotes neutrophil activation. Neufert, C., Pai, R.K., Noss, E.H., Berger, M., Boom, W.H., Harding, C.V. J. Immunol. (2001) [Pubmed]
  10. Metabolism-dependent stimulation of reactive oxygen species and DNA synthesis by cyclosporin A in rat smooth muscle cells. Nguyen, N.S., Cottet-Maire, F., Buetler, T.M., Lo Russo, A., Krauskopf, A.S., Armstrong, J.M., Vickers, A.E., Macé, K., Rüegg, U.T. Free Radic. Biol. Med. (1999) [Pubmed]
  11. Hypercholesterolemia enhances oxidant production in mesenteric venules exposed to Ischemia/Reperfusion. Kurose, I., Wolf, R.E., Grisham, M.B., Granger, D.N. Arterioscler. Thromb. Vasc. Biol. (1998) [Pubmed]
  12. Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. Szabó, C., Salzman, A.L., Ischiropoulos, H. FEBS Lett. (1995) [Pubmed]
  13. Flow cytometric measurement of neutrophil respiratory burst in whole bovine blood using live Staphylococcus aureus. Kampen, A.H., Tollersrud, T., Lund, A. J. Immunol. Methods (2004) [Pubmed]
  14. Flow cytometric analysis of peroxidative activity in granulocytes from coronary and peripheral blood in acute myocardial ischemia and reperfusion in dogs: protective effect of methionine. Such, L., O'Connor, J.E., Sáez, G.T., Gil, F., Beltrán, J.F., Moya, A., Alberola, A. Cytometry. (1999) [Pubmed]
  15. Simultaneous flow cytometric measurement of phagocytotic and oxidative burst activity of polymorphonuclear leukocytes in whole bovine blood. Smits, E., Burvenich, C., Heyneman, R. Vet. Immunol. Immunopathol. (1997) [Pubmed]
  16. Inhibition of succinate:ubiquinone reductase and decrease of ubiquinol in nephrotoxic cysteine S-conjugate-induced oxidative cell injury. van de Water, B., Zoeteweij, J.P., de Bont, H.J., Nagelkerke, J.F. Mol. Pharmacol. (1995) [Pubmed]
  17. Prospective randomized comparison of cefodizime versus cefuroxime for perioperative prophylaxis in patients undergoing coronary artery bypass grafting. Wenisch, C., Bartunek, A., Zedtwitz-Liebenstein, K., Hiesmayr, M., Parschalk, B., Pernerstorfer, T., Graninger, W. Antimicrob. Agents Chemother. (1997) [Pubmed]
  18. Deposition of reactive oxygen metabolites onto and within living tumor cells during neutrophil-mediated antibody-dependent cellular cytotoxicity. Cao, D., Boxer, L.A., Petty, H.R. J. Cell. Physiol. (1993) [Pubmed]
  19. Protection by organotellurium compounds against peroxynitrite-mediated oxidation and nitration reactions. Briviba, K., Tamler, R., Klotz, L.O., Engman, L., Cotgreave, I.A., Sies, H. Biochem. Pharmacol. (1998) [Pubmed]
  20. NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in d-2-hydroxyglutaric aciduria. Kölker, S., Pawlak, V., Ahlemeyer, B., Okun, J.G., Hörster, F., Mayatepek, E., Krieglstein, J., Hoffmann, G.F., Köhr, G. Eur. J. Neurosci. (2002) [Pubmed]
  21. Accumulation of DNA, nuclear and mitochondrial debris, and ROS at sites of age-related cortical cataract in mice. Pendergrass, W., Penn, P., Possin, D., Wolf, N. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  22. H2O2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes. Peus, D., Vasa, R.A., Meves, A., Pott, M., Beyerle, A., Squillace, K., Pittelkow, M.R. J. Invest. Dermatol. (1998) [Pubmed]
  23. Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation. Dugo, L., Serraino, I., Fulia, F., De Sarro, A., Caputi, A.P., Cuzzocrea, S. J. Pineal Res. (2001) [Pubmed]
  24. Melatonin as an antioxidant in retinal photoreceptors. Marchiafava, P.L., Longoni, B. J. Pineal Res. (1999) [Pubmed]
  25. Proteins of the extracellular matrix are sensitizers of photo-oxidative stress in human skin cells. Wondrak, G.T., Roberts, M.J., Cervantes-Laurean, D., Jacobson, M.K., Jacobson, E.L. J. Invest. Dermatol. (2003) [Pubmed]
  26. Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamylcysteine synthetase and increases intracellular glutathione levels. Wild, A.C., Mulcahy, R.T. Biochem. J. (1999) [Pubmed]
  27. Susceptibility of melanized and nonmelanized Cryptococcus neoformans to the melanin-binding compounds trifluoperazine and chloroquine. Wang, Y., Casadevall, A. Antimicrob. Agents Chemother. (1996) [Pubmed]
  28. Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in HepG2 cells. Ehleben, W., Porwol, T., Fandrey, J., Kummer, W., Acker, H. Kidney Int. (1997) [Pubmed]
  29. Nitric oxide enhances the manganese superoxide dismutase-dependent suppression of proliferation in HT-1080 fibrosarcoma cells. Melendez, J.A., Melathe, R.P., Rodriguez, A.M., Mazurkiewicz, J.E., Davies, K.J. Cell Growth Differ. (1999) [Pubmed]
  30. Water-soluble organotellurium compounds: catalytic protection against peroxynitrite and release of zinc from metallothionein. Jacob, C., Arteel, G.E., Kanda, T., Engman, L., Sies, H. Chem. Res. Toxicol. (2000) [Pubmed]
  31. Cyclooxygenase-2 inhibition lacks immunomodulatory effects on T cells. Rivero, M., Santiago, B., Galindo, M., Brehmer, M.T., Pablos, J.L. Clinical and experimental rheumatology. (2002) [Pubmed]
  32. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): a Fc gamma RII-dependent process. Mulder, A.H., Heeringa, P., Brouwer, E., Limburg, P.C., Kallenberg, C.G. Clin. Exp. Immunol. (1994) [Pubmed]
  33. The tripeptide feG regulates the production of intracellular reactive oxygen species by neutrophils. Mathison, R.D., Davison, J.S. Journal of inflammation (London, England) (2006) [Pubmed]
  34. The isolated perfused liver response to a 'second hit' of portal endotoxin during severe acute pancreatitis. Mole, D.J., Taylor, M.A., McFerran, N.V., Diamond, T. Pancreatology (2005) [Pubmed]
  35. Rac1, and not Rac2, is involved in the regulation of the intracellular hydrogen peroxide level in HepG2 cells. Cool, R.H., Merten, E., Theiss, C., Acker, H. Biochem. J. (1998) [Pubmed]
  36. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Goossens, V., Grooten, J., De Vos, K., Fiers, W. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  37. NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines. Wang, D., Youngson, C., Wong, V., Yeger, H., Dinauer, M.C., Vega-Saenz Miera, E., Rudy, B., Cutz, E. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  38. Light-dependent generation of reactive oxygen species in cell culture media. Grzelak, A., Rychlik, B., Bartosz, G. Free Radic. Biol. Med. (2001) [Pubmed]
  39. Alterations of intracellular calcium homeostasis and mitochondrial function are involved in ruthenium red neurotoxicity in primary cortical cultures. Velasco, I., Tapia, R. J. Neurosci. Res. (2000) [Pubmed]
  40. Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Cuzzocrea, S., Zingarelli, B., Costantino, G., Szabó, A., Salzman, A.L., Caputi, A.P., Szabó, C. Br. J. Pharmacol. (1997) [Pubmed]
WikiGenes - Universities