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Chemical Compound Review:

Valamine 2-methylpropan-1-amine

Synonyms: ISOBUTYLAMINE, I-Butylamine, iso-Butylamine, HSDB 612, NSC-8028, ...

Bailey, S.R. et al., Zhong, Z. et al., Parry, R.J. et al., Wang, L. et al., Price, M.A. et al., et al.

Zhong, Chen, Ang, Han, Lim, Gedanken, Parry, Li, Cooper,

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Disease relevance of NSC 8028

IFN-gamma and TNF-alpha, whose optimum production was dependent on IBA-stimulated gammadelta T cells, were critical for monocyte-mediated killing of Escherichia coli [1].

High impact information on NSC 8028

The gene (vlmR) encoding the flavin reductase required by isobutylamine hydroxylase has been cloned from S. viridifaciens by chromosome walking [2].
The flavoprotein isobutylamine N-hydroxylase (IBAH) catalyzes the oxidation of isobutylamine to isobutylhydroxylamine, a key step in the biosynthesis of the azoxy antibiotic valanimycin [3].
Titanium dioxide was synthesized by the hydrolysis of titanium tetraisopropoxide (TTIP) in the presence of acetic acid, 2-propanol, and organic amines (octylamine, aniline, and isobutylamine) [4].
The enzyme system produced by Cryptococcus laurentii CBS 7140 failed to oxidize isobutylamine and benzylamine, and showed a high pH optimum [5].
All 6 caecally-derived amines examined (tyramine, spermine, isoamylamine, tryptamine, phenylethylamine and isobutylamine) inhibited the total uptake of [3H]5-HT in a concentration-dependent manner, tyramine having the lowest IC50 (3.7 x 10(-6) mol/l) [6].

Associations of NSC 8028 with other chemical compounds

The mixture of isoamylamine and isobutylamine did not accelerate puberty, but direct contact with the male urine accelerated puberty as evidenced by uterine weights [7].

References

Human V gamma 2V delta 2 T cells produce IFN-gamma and TNF-alpha with an on/off/on cycling pattern in response to live bacterial products. Wang, L., Das, H., Kamath, A., Bukowski, J.F. J. Immunol. (2001) [Pubmed]
An NADPH:FAD oxidoreductase from the valanimycin producer, Streptomyces viridifaciens. Cloning, analysis, and overexpression. Parry, R.J., Li, W. J. Biol. Chem. (1997) [Pubmed]
Cloning, analysis, and overexpression of the gene encoding isobutylamine N-hydroxylase from the valanimycin producer, Streptomyces viridifaciens. Parry, R.J., Li, W., Cooper, H.N. J. Bacteriol. (1997) [Pubmed]
Impact of growth kinetics on morphology and pore structure of TiO2-one-pot synthesis of macroporous TiO2 microspheres. Zhong, Z., Chen, F., Ang, T.P., Han, Y., Lim, W., Gedanken, A. Inorganic chemistry. (2006) [Pubmed]
Oxidation of amines by yeasts grown on 1-aminoalkanes or putrescine as the sole source of carbon, nitrogen and energy. Middlehoven, W.J., Hoogkamer-Te Niet, M.C., De Laat, W.T., Weijers, C., Bulder, C.J. Antonie Van Leeuwenhoek (1986) [Pubmed]
Uptake of 5-hydroxytryptamine by equine digital vein endothelial cells: inhibition by amines found in the equine caecum. Bailey, S.R., Wheeler-Jones, C., Elliott, J. Equine Vet. J. (2003) [Pubmed]
Analysis of puberty-accelerating pheromones. Price, M.A., Vandenbergh, J.G. J. Exp. Zool. (1992) [Pubmed]

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