Disease relevance of trihexyphenidyl

• We report a patient with Parkinson's disease who developed orobuccal dyskinesia while being treated with trihexyphenidyl (Artane) [1].

Psychiatry related information on trihexyphenidyl

• 13 patients with PD of recent onset underwent a series of neuropsychological tests for frontal lobe associated functions (Sternberg paradigm, WCST, CVLT) before and during treatment with Artane [2].
• Artane abusers, when compared with users, were significantly characterized by less negative psychopathology [3].

High impact information on trihexyphenidyl

• Five proposed bleeding criteria or markers for the onset of early menopausal transition and four criteria for the onset of the late transition were evaluated using data from the Menstruation and Reproductive History Study, or Tremin Trust [4].
• This method has been successfully applied to bioavailability studies after Parkinane and Artane administration to humans [5].
• The addition of atropine sulphate (1 microgram/ml) to the collecting fluid or the administration of Artane (2 mg/kg i.v.) increased resting ACh release from both the hippocampus and cortex to similar output levels [6].
• The proposed method is applied to the Tremin Trust data to evaluate the association between age at onset of the 60-day menstrual cycle and age at menopause [7].
• At 18 years he was given benzhexol (Artane), increased slowly from 2 mg to 6 mg daily, resulting in improvement in tremor and dystonia [8].

Biological context of trihexyphenidyl

• Data are drawn from the Tremin Trust, a longitudinal study of menstrual cycles that recruited white women who were students at the University of Minnesota and from a survey of a nationally representative sample of white women born between 1900 and 1910 [9].
• The efficacy of pretreatment regimens (PRG) (composed of PHY in combination with either scopolamine (SCP) or trihexyphenidyl (artane; ART] was evaluated in guinea pigs challenged with soman (98 ug/kg, sc; 3.5 LD50) to determine the dose of PHY and adjunct required for optimal efficacy as well as the better of the two adjuncts [10].

Gene context of trihexyphenidyl

• Trihexyphenidyl (Artane) is a centrally active muscarinic antagonist commonly used to treat patients with generalized dystonia [11].

References