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Chemical Compound Review

Cyclodol     1-cyclohexyl-1-phenyl-3-(1...

Synonyms: Pacitane, Paralest, Pargitan, Parkopan, Parcopane, ...
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Disease relevance of trihexyphenidyl


Psychiatry related information on trihexyphenidyl


High impact information on trihexyphenidyl

  • Five proposed bleeding criteria or markers for the onset of early menopausal transition and four criteria for the onset of the late transition were evaluated using data from the Menstruation and Reproductive History Study, or Tremin Trust [4].
  • This method has been successfully applied to bioavailability studies after Parkinane and Artane administration to humans [5].
  • The addition of atropine sulphate (1 microgram/ml) to the collecting fluid or the administration of Artane (2 mg/kg i.v.) increased resting ACh release from both the hippocampus and cortex to similar output levels [6].
  • The proposed method is applied to the Tremin Trust data to evaluate the association between age at onset of the 60-day menstrual cycle and age at menopause [7].
  • At 18 years he was given benzhexol (Artane), increased slowly from 2 mg to 6 mg daily, resulting in improvement in tremor and dystonia [8].

Biological context of trihexyphenidyl

  • Data are drawn from the Tremin Trust, a longitudinal study of menstrual cycles that recruited white women who were students at the University of Minnesota and from a survey of a nationally representative sample of white women born between 1900 and 1910 [9].
  • The efficacy of pretreatment regimens (PRG) (composed of PHY in combination with either scopolamine (SCP) or trihexyphenidyl (artane; ART] was evaluated in guinea pigs challenged with soman (98 ug/kg, sc; 3.5 LD50) to determine the dose of PHY and adjunct required for optimal efficacy as well as the better of the two adjuncts [10].

Gene context of trihexyphenidyl


  1. Orobuccal dyskinesia associated with trihexyphenidyl therapy in a patient with Parkinson's disease. Hauser, R.A., Olanow, C.W. Mov. Disord. (1993) [Pubmed]
  2. Effects of treatment with trihexyphenidyl on cognitive function in early Parkinson's disease. Schelosky, L., Benke, T., Poewe, W.H. J. Neural Transm. Suppl. (1991) [Pubmed]
  3. Trihexyphenidyl (Artane) dependence: A controlled investigation between users and abusers. Qureshi, N.A., Al Amri, A.H., Abdelgadir, M.H., El-Haraka, E.A. Annals of Saudi medicine (1997) [Pubmed]
  4. Staging reproductive aging: a comparison of proposed bleeding criteria for the menopausal transition. Lisabeth, L.D., Harlow, S.D., Gillespie, B., Lin, X., Sowers, M.F. Menopause (New York, N.Y.) (2004) [Pubmed]
  5. Quantitation of trihexyphenidyl from plasma using a mass-selective detector and electron-impact ionization. Desage, M., Rousseau-Tsangaris, M., Lecompte, D., Brazier, J.L. J. Chromatogr. (1991) [Pubmed]
  6. The role of the septal nuclei in the release of acetyl-choline from the rabbit cerebral cortex and dorsal hippocampus and the effect of atropine. Dudar, J.D. Brain Res. (1977) [Pubmed]
  7. A varying-coefficient Cox model for the effect of age at a marker event on age at menopause. Nan, B., Lin, X., Lisabeth, L.D., Harlow, S.D. Biometrics (2005) [Pubmed]
  8. 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency in a 23-year-old man. Olpin, S.E., Pollitt, R.J., McMenamin, J., Manning, N.J., Besley, G., Ruiter, J.P., Wanders, R.J. J. Inherit. Metab. Dis. (2002) [Pubmed]
  9. Menarcheal age and subsequent patterns of family formation. Riley, A.P., Weinstein, M., Ridley, J.C., Mormino, J., Gorrindo, T. Social biology. (2001) [Pubmed]
  10. Comparing the response surfaces of two cholinolytics when used in combination with physostigmine as a pretreatment against organophosphate challenge. Solana, R.P., Gennings, C., Anderson, D., Carter, W.H., Carchman, R.A., Harris, L.W. Drug and chemical toxicology. (1989) [Pubmed]
  11. Age-dependent effects of trihexyphenidyl in extrapyramidal cerebral palsy. Hoon, A.H., Freese, P.O., Reinhardt, E.M., Wilson, M.A., Lawrie, W.T., Harryman, S.E., Pidcock, F.S., Johnston, M.V. Pediatric neurology. (2001) [Pubmed]
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