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Chemical Compound Review:

SureCN70219 naphthalene-1,8-diol

Synonyms: CHEMBL203537, AC-950, AG-G-00421, ANW-49163, KST-1B5925, ...

Oatis, J.E. et al., Butler, M.J. et al., Feng, B. et al., Wheeler, M.H. et al.

Butler, Gardiner, Day,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on AIDS-017776

1,8-Dihydroxynaphthalene (1,8-DHN) is a fungal polyketide that contributes to virulence when polymerized to 1,8-DHN melanin in the cell walls of Wangiella dermatitidis, an agent of phaeohyphomycosis in humans [1].
Cleavage og the methyl group in fused pyridine hydrochloride afforded 1a,c-f. 1g was prepared by the direct alkylation of 1,8-naphthalenediol (17) with epichlorohydrin, followed by reaction with isopropylamine [2].
Ultrastructural and chemical distinction of melanins formed by Verticillium dahliae from (+)-scytalone, 1,8-dihydroxynaphthalene, catechol, and L-3,4-dihydroxyphenylalanine [3].

Analytical, diagnostic and therapeutic context of AIDS-017776

Silver-staining procedures were investigated for their effectiveness in identifying cell wall-based fungal melanins in live and fixed plastic embedded samples, particularly 1,8-dihydroxynaphthalene (DHN) based polyketide melanins [4].

References

Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala) dermatitidis. Feng, B., Wang, X., Hauser, M., Kaufmann, S., Jentsch, S., Haase, G., Becker, J.M., Szaniszlo, P.J. Infect. Immun. (2001) [Pubmed]
Ring-hydroxylated propranolol: synthesis and beta-receptor antagonist and vasodilating activities of the seven isomers. Oatis, J.E., Russell, M.P., Knapp, D.R., Walle, T. J. Med. Chem. (1981) [Pubmed]
Ultrastructural and chemical distinction of melanins formed by Verticillium dahliae from (+)-scytalone, 1,8-dihydroxynaphthalene, catechol, and L-3,4-dihydroxyphenylalanine. Wheeler, M.H., Tolmsoff, W.J., Bell, A.A., Mollenhauer, H.H. Can. J. Microbiol. (1978) [Pubmed]
Fungal melanin detection by the use of copper sulfide-silver. Butler, M.J., Gardiner, R.B., Day, A.W. Mycologia (2005) [Pubmed]

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