High impact information on Caprin

• Treatment with tricaprin resulted in prominent and enlarged Kupffer cells possibly with increase numbers of dense bodies [1].
• Tricaprin increase the rate of spreading of macrophages on glass [2].
• RESULTS: No statistically significant differences were observed in gastric emptying between the groups fed the different fats, except for the emptying of tridecanoin (tri-10:0) that was statistically significantly slower than that of randomized oil, cocoa butter, and rapeseed oil (p < 0.05) [3].
• Five nanograms for tricaproin (MCT-6), 10 ng for tricaprylin (MCT-8) and 15 ng for tricaprin (MCT-9) represent the GLC detection limits of MCT, while those of MCFA range from 40 to 15 ng depending on their chain length: the longer the chain length, the higher the detection limit [4].
• The patient's lipoprotein lipase hydrolyzed triolein emulsified with 2% tricaprin at the same rate as that of control lipoprotein lipase [5].

Associations of Caprin with other chemical compounds

• The purpose of this study was to investigate the effect of 2 additives, poly(ethylene glycol) (PEG) 1000 and 1,2,3-tridecanoyl glycerol (tricaprin), on the physico-chemical characteristics and in vitro release of a model protein, bovine serum albumin (BSA), form poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres [6].

Gene context of Caprin

• Tricaprylin (C8), tricaprin (C10), a mixture of C8 and C10 (mixed MCT) or soya oil were given at 11-18 days of age [7].

Analytical, diagnostic and therapeutic context of Caprin

• The percentage of tricaprin used did not significantly affect the drug loading efficiency of the microspheres [8].
• The plasma TG level, on the other hand, increased from 11.9 to 19.2 mmol/l (+61%) at 6 h after loading a fatty meal containing LCT, whereas the plasma TG levels tended to even decrease at 6 h after oral administration of an MCT, tricaprin (from 11.6 to 10.5 mmol/l (-9.4%)) [9].

References