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MeSH Review

Brassica rapa

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Disease relevance of Brassica rapa

  • We investigated how effectively postmenopausal women with a previous myocardial infarction reduced their serum cholesterol with dietary means by using sitostanol ester rapeseed oil margarine, alone and in combination with statins, and to what extent cholesterol metabolism was affected [1].
  • The hypothesis that dietary erucic acid may contribute to the pathogenesis of intrahepatic cholestasis of pregnancy has been examined in pregnant rats and hamsters after prolonged feeding of diets containing 25% rapeseed oil rich in erucic acid (40% of fatty acids) or corn oil, without erucic acid [2].
  • In a parallel approach, a cDNA was isolated from a rapeseed library by its ability to complement the Etn requirement of a yeast cho1 mutant and shown by expression in E. coli to specify SDC [3].
  • Synechococcus transformed with a chimeric gene that contains a prokaryotic promoter fused to the rapeseed cDNA encoding all but the first 73 amino acids partially converted its oleic acid fatty acid to linoleic acid, and the 16:1(9c) fatty acid was converted primarily to 16:2(9c, 12) in vivo [4].
  • Normal circulating triiodothyronine concentrations are maintained despite severe hypothyroidism in growing pigs fed rapeseed presscake meal [5].

Psychiatry related information on Brassica rapa


High impact information on Brassica rapa

  • RESULTS: 1,3-Butadiene, benzene, acrolein, formaldehyde, and other related compounds were qualitatively and quantitatively detected, with emissions tending to be highest for unrefined Chinese rapeseed oil and lowest for peanut oil [9].
  • The oils tested were unrefined Chinese rapeseed, refined U.S. rapeseed (known as canola), Chinese soybean, and Chinese peanut in addition to linolenic, linoleic, and erucic fatty acids [9].
  • The emission of 1,3-butadiene and benzene was approximately 22-fold and 12-fold higher, respectively, from heated unrefined Chinese rapeseed oil than from heated peanut oil [9].
  • The epidemic has been traced to ingestion of rapeseed oil, denatured with aniline and containing acetanilide [10].
  • Prevention by menadione of the hepatotoxic effects in chickens fed rapeseed meal. Observations on coagulation factors and cytochrome P-450 [11].

Chemical compound and disease context of Brassica rapa

  • The hydrophobic fraction obtained by the extraction of seeds with methylene chloride showed no toxicity; the behavior of tested animals was similar to that of the group given an equivalent dose of rapeseed oil [12].
  • The objective of this work was to study the effect of the extraction of phenols by methanol/acetone/water and proteolysis (pepsin 1 hour; trypsin 2 hours) on the nutritional characteristics of unheated rapeseed protein as measured by weight gain, protein intake, net protein ratio, apparent digestibility and absorbed protein [13].
  • A combination of a rapeseed diet and the administration of carbon tetrachloride (CCl4) also led to hepatocellular hypertrophy but the histological picture of the cirrhosis was similar to the one in control animals receiving CCl4 alone [14].
  • The use of a rapeseed oil emulsion feed, produced by a phase inversion temperature (PIT) process, produced more biomass, gave a 3-fold increase in oil utilisation and a higher oxytetracycline titre but a higher residual oil concentration when compared to a conventional fed-batch Streptomyces rimosus process fed with crude rapeseed oil [15].

Biological context of Brassica rapa


Anatomical context of Brassica rapa


Associations of Brassica rapa with chemical compounds


Gene context of Brassica rapa

  • Factor VIII and von Willebrand factor proteins were evaluated in 115 patients having the chronic phase of the Toxic Epidemic Syndrome (TES), a new multisystemic disease probably caused by the ingestion of denatured rapeseed oil, and in 50 control volunteers [31].
  • Feeding rapeseed oil increased the antioxidant enzyme (AOE) activities (catalase, superoxide dismutase, glutathion reductase), glutathione concentration, and value from the benzoic acid test [32].
  • Ten, seven, and 39 C-to-U RNA editing events occur in the rapeseed nad3, rps12, and ccb206 transcripts, respectively [33].
  • Seed-specific antisense gene constructs of B. rapa stearoyl-ACP desaturase were used to reduce the protein concentration and enzyme activity of stearoyl-ACP desaturase in developing rapeseed embryos during storage lipid biosynthesis [34].
  • A rapeseed cold-inducible transcript encodes a phosphoenolpyruvate carboxykinase [35].

Analytical, diagnostic and therapeutic context of Brassica rapa


  1. Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: women and dietary sitostanol. Gylling, H., Radhakrishnan, R., Miettinen, T.A. Circulation (1997) [Pubmed]
  2. Is dietary erucic acid hepatotoxic in pregnancy? An experimental study in rats and hamsters. Reyes, H., Ribalta, J., Hernández, I., Arrese, M., Pak, N., Wells, M., Kirsch, R.E. Hepatology (1995) [Pubmed]
  3. Plants synthesize ethanolamine by direct decarboxylation of serine using a pyridoxal phosphate enzyme. Rontein, D., Nishida, I., Tashiro, G., Yoshioka, K., Wu, W.I., Voelker, D.R., Basset, G., Hanson, A.D. J. Biol. Chem. (2001) [Pubmed]
  4. Cloning of a higher-plant plastid omega-6 fatty acid desaturase cDNA and its expression in a cyanobacterium. Hitz, W.D., Carlson, T.J., Booth, J.R., Kinney, A.J., Stecca, K.L., Yadav, N.S. Plant Physiol. (1994) [Pubmed]
  5. Normal circulating triiodothyronine concentrations are maintained despite severe hypothyroidism in growing pigs fed rapeseed presscake meal. Spiegel, C., Bestetti, G.E., Rossi, G.L., Blum, J.W. J. Nutr. (1993) [Pubmed]
  6. Food intake, growth rate, food conversion and food choice in broilers fed on diets high in rapeseed meal and pea meal, with observations on sensory evaluation of the resulting poultry meat. McNeill, L., Bernard, K., MacLeod, M.G. Br. Poult. Sci. (2004) [Pubmed]
  7. Effects of dietary vegetable oils on behavior and drug responses in mice. Kameyama, T., Ohhara, T., Nakashima, Y., Naito, Y., Huang, M.Z., Watanabe, S., Kobayashi, T., Okuyama, H., Yamada, K., Nabeshima, T. Biol. Pharm. Bull. (1996) [Pubmed]
  8. Two-step preparation for catalyst-free biodiesel fuel production: hydrolysis and methyl esterification. Kusdiana, D., Saka, S. Appl. Biochem. Biotechnol. (2004) [Pubmed]
  9. Mutagens from heated Chinese and U.S. cooking oils. Shields, P.G., Xu, G.X., Blot, W.J., Fraumeni, J.F., Trivers, G.E., Pellizzari, E.D., Qu, Y.H., Gao, Y.T., Harris, C.C. J. Natl. Cancer Inst. (1995) [Pubmed]
  10. Toxic-allergic syndrome caused by ingestion of rapeseed oil denatured with aniline. Tabuenca, J.M. Lancet (1981) [Pubmed]
  11. Prevention by menadione of the hepatotoxic effects in chickens fed rapeseed meal. Observations on coagulation factors and cytochrome P-450. Israels, E.D., Papas, A., Campbell, L.D., Israels, L.G. Gastroenterology (1979) [Pubmed]
  12. Determination and toxicity of saponins from Amaranthus cruentus seeds. Oleszek, W., Junkuszew, M., Stochmal, A. J. Agric. Food Chem. (1999) [Pubmed]
  13. Effect of methanol/acetone/water extraction and enzymatic hydrolysis on the nutritional value of unheated rapeseed proteins. Lacroix, M., Amiot, J., Cheour, F., De La Noüe, J., Goulet, G., Brisson, G.J. Plant foods for human nutrition (Dordrecht, Netherlands) (1988) [Pubmed]
  14. Rapeseed diet and hepatocyte hypertrophy: an experimental morphometric study. Alvizouri-Muñoz, M., Angeles-Angeles, A., Orozco Estévez, H., Larriva-Sahd, J. Rev. Invest. Clin. (1992) [Pubmed]
  15. The use of phase inversion temperature (PIT) microemulsion technology to enhance oil utilisation during Streptomyces rimosus fed-batch fermentations to produce oxytetracycline. Papapanagiotou, P.A., Quinn, H., Molitor, J.P., Nienow, A.W., Hewitt, C.J. Biotechnol. Lett. (2005) [Pubmed]
  16. Developmental stage-specific and nitrate-independent regulation of nitrate reductase gene expression in rapeseed. Fukuoka, H., Ogawa, T., Minami, H., Yano, H., Ohkawa, Y. Plant Physiol. (1996) [Pubmed]
  17. Early stages of seed development in Brassica napus: a seed coat-specific cysteine proteinase associated with programmed cell death of the inner integument. Wan, L., Xia, Q., Qiu, X., Selvaraj, G. Plant J. (2002) [Pubmed]
  18. Rapeseed oil and sunflower oil diets enhance platelet in vitro aggregation and thromboxane production in healthy men when compared with milk fat or habitual diets. Mutanen, M., Freese, R., Valsta, L.M., Ahola, I., Ahlström, A. Thromb. Haemost. (1992) [Pubmed]
  19. Lymphatic transport in rats of several dietary fats differing in fatty acid profile and triacylglycerol structure. Porsgaard, T., Høy, C.E. J. Nutr. (2000) [Pubmed]
  20. Effects of high and low erucic acid rapeseed oils on energy metabolism and mitochondrial function of the chick. Renner, R., Innis, S.M., Clandinin, M.T. J. Nutr. (1979) [Pubmed]
  21. Stereospecific incorporation of palmitoyl, oleoyl and linoleoyl moieties into adipose tissue triacylglycerols of rats results in constant sn-1:sn-2:sn-3 in rats fed rapeseed, olive, conventional or high oleic sunflower oils, but not in those fed coriander oil. Weber, N., Klein, E., Mukherjee, K.D. J. Nutr. (2003) [Pubmed]
  22. Morphometric analysis demonstrates that metabolically active cardiac triglycerides are 1H NMR visible. Madden, M.C., van Winkle, W.B., Vaughn, J.M., Pohost, G.M., Wolkowicz, P.E. J. Mol. Cell. Cardiol. (1993) [Pubmed]
  23. The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. Bourre, J.M., Francois, M., Youyou, A., Dumont, O., Piciotti, M., Pascal, G., Durand, G. J. Nutr. (1989) [Pubmed]
  24. Electrotransfection of turnip yellow mosaic virus RNA into Brassica leaf protoplasts and detection of viral RNA products with a non-radioactive probe. Boyer, J.C., Zaccomer, B., Haenni, A.L. J. Gen. Virol. (1993) [Pubmed]
  25. Lower food intake is a primary cause of reduced growth rate in growing pigs fed rapeseed presscake meal. Spiegel, C., Blum, J.W. J. Nutr. (1993) [Pubmed]
  26. Surface structure and properties of plant seed oil bodies. Tzen, J.T., Huang, A.H. J. Cell Biol. (1992) [Pubmed]
  27. A jojoba beta-Ketoacyl-CoA synthase cDNA complements the canola fatty acid elongation mutation in transgenic plants. Lassner, M.W., Lardizabal, K., Metz, J.G. Plant Cell (1996) [Pubmed]
  28. A diet rich in monounsaturated rapeseed oil reduces the lipoprotein cholesterol concentration and increases the relative content of n-3 fatty acids in serum in hyperlipidemic subjects. Gustafsson, I.B., Vessby, B., Ohrvall, M., Nydahl, M. Am. J. Clin. Nutr. (1994) [Pubmed]
  29. The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women. Kratz, M., von Eckardstein, A., Fobker, M., Buyken, A., Posny, N., Schulte, H., Assmann, G., Wahrburg, U. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  30. Lysophosphatidic acid acyltransferase from meadowfoam mediates insertion of erucic acid at the sn-2 position of triacylglycerol in transgenic rapeseed oil. Lassner, M.W., Levering, C.K., Davies, H.M., Knutzon, D.S. Plant Physiol. (1995) [Pubmed]
  31. High levels of plasma FVIII and vWF in the toxic epidemic syndrome patients. López-Fernández, M.F., López-Berges, C., Fermoso, J., Martín-Pascual, A., Sánchez-Hernández, J.J., López-Borrasca, A., Batlle, J. Thromb. Haemost. (1989) [Pubmed]
  32. Influence of dietary fat and vitamin E on antioxidant status of muscles of turkey. Renerre, M., Poncet, K., Mercier, Y., Gatellier, P., Métro, B. J. Agric. Food Chem. (1999) [Pubmed]
  33. Rapeseed mitochondrial ccb206, a gene involved in cytochrome c biogenesis, is co-transcribed with the nad3 and rps12 genes: organization, transcription, and RNA editing of the nad3/rps12/ccb206 locus. Itani, K., Handa, H. Curr. Genet. (1998) [Pubmed]
  34. Modification of Brassica seed oil by antisense expression of a stearoyl-acyl carrier protein desaturase gene. Knutzon, D.S., Thompson, G.A., Radke, S.E., Johnson, W.B., Knauf, V.C., Kridl, J.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  35. A rapeseed cold-inducible transcript encodes a phosphoenolpyruvate carboxykinase. Sáez-Vásquez, J., Raynal, M., Delseny, M. Plant Physiol. (1995) [Pubmed]
  36. Effect of sesamin on mitochondrial and peroxisomal beta-oxidation of arachidonic and eicosapentaenoic acids in rat liver. Umeda-Sawada, R., Ogawa, M., Nakamura, M., Igarashi, O. Lipids (2001) [Pubmed]
  37. Characterization of cysteine residues involved in the reductive activation and the structural stability of rapeseed (Brassica napus) chloroplast fructose-1,6-bisphosphatase. Rodriguez-Suarez, R.J., Mora-García, S., Wolosiuk, R.A. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  38. Purification and characterization of phosphoenolpyruvate carboxylase from Brassica napus (rapeseed) suspension cell cultures: implications for phosphoenolpyruvate carboxylase regulation during phosphate starvation, and the integration of glycolysis with nitrogen assimilation. Moraes, T.F., Plaxton, W.C. Eur. J. Biochem. (2000) [Pubmed]
  39. The degradation of different protein supplements in the rumen of steers and the effects of these supplements on carbohydrate digestion. McAllan, A.B., Cockburn, J.E., Williams, A.P., Smith, R.H. Br. J. Nutr. (1988) [Pubmed]
  40. Ethoxylated rapeseed oil derivatives as novel adjuvants for herbicides. Müller, T., Brancq, B., Milius, A., Okori, N., Vaille, C., Gauvrit, C. Pest Manag. Sci. (2002) [Pubmed]
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