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Chemical Compound Review

Orotaldehyde     2,6-dioxo-3H-pyrimidine-4- carbaldehyde

Synonyms: OROTALALDEHYDE, CCRIS 8816, NSC-104159, AC1Q6BKA, AC1Q6PSS, ...
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Disease relevance of NSC104159


High impact information on NSC104159


Biological context of NSC104159


Associations of NSC104159 with other chemical compounds


Gene context of NSC104159


  1. Identification of repair enzymes for 5-formyluracil in DNA. Nth, Nei, and MutM proteins of Escherichia coli. Zhang, Q.M., Miyabe, I., Matsumoto, Y., Kino, K., Sugiyama, H., Yonei, S. J. Biol. Chem. (2000) [Pubmed]
  2. 5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism. Klungland, A., Paulsen, R., Rolseth, V., Yamada, Y., Ueno, Y., Wiik, P., Matsuda, A., Seeberg, E., Bjelland, S. Toxicol. Lett. (2001) [Pubmed]
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  4. Stable, specific, and reversible base pairing via Schiff base. Dohno, C., Okamoto, A., Saito, I. J. Am. Chem. Soc. (2005) [Pubmed]
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  6. Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions. Masaoka, A., Matsubara, M., Hasegawa, R., Tanaka, T., Kurisu, S., Terato, H., Ohyama, Y., Karino, N., Matsuda, A., Ide, H. Biochemistry (2003) [Pubmed]
  7. Oxidation of thymine to 5-formyluracil in DNA: mechanisms of formation, structural implications, and base excision by human cell free extracts. Bjelland, S., Eide, L., Time, R.W., Stote, R., Eftedal, I., Volden, G., Seeberg, E. Biochemistry (1995) [Pubmed]
  8. Mutagenic effects of 5-formyluracil on a plasmid vector during replication in Escherichia coli. Miyabe, I., Zhang, Q.M., Sugiyama, H., Kino, K., Yonei, S. Int. J. Radiat. Biol. (2001) [Pubmed]
  9. Mutagenicity of 5-formyluracil in mammalian cells. Kamiya, H., Murata-Kamiya, N., Karino, N., Ueno, Y., Matsuda, A., Kasai, H. Nucleic Acids Symp. Ser. (2000) [Pubmed]
  10. Cu(II) complexes with heterocyclic substituted thiosemicarbazones: the case of 5-formyluracil. Synthesis, characterization, x-ray structures, DNA interaction studies, and biological activity. Baldini, M., Belicchi-Ferrari, M., Bisceglie, F., Pelosi, G., Pinelli, S., Tarasconi, P. Inorganic chemistry. (2003) [Pubmed]
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  12. Synthesis, characterisation, X-ray structure and biological activity of three new 5-formyluracil thiosemicarbazone complexes. Ferrari, M.B., Bisceglie, F., Pelosi, G., Tarasconi, P., Albertin, R., Bonati, A., Lunghi, P., Pinelli, S. J. Inorg. Biochem. (2001) [Pubmed]
  13. Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein. Miyabe, I., Zhang, Q.M., Kino, K., Sugiyama, H., Takao, M., Yasui, A., Yonei, S. Nucleic Acids Res. (2002) [Pubmed]
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