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Chemical Compound Review

AC1MBZLL     N-[4-[ (carbamothioylhydrazinylidene) methyl...

Synonyms: AG-C-14988, AG-D-15782, CTK6A0755, KB-188929, MCULE-4893643717, ...
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Disease relevance of Thioacetazon


High impact information on Thioacetazon

  • In contrast, MAb 42/6 had minimal effects on cytotoxicity of the ribonucleotide reductase inhibitor, isoquinaldehyde thiosemicarbazone, to either HL60 or KB cells [5].
  • Among HIV-positive patients who received treatment for active tuberculosis, thiacetazone has been associated with cutaneous hypersensitivity and recurrent tuberculosis [1].
  • As an alternative approach to using P-gp inhibitors, we characterize a thiosemicarbazone derivative (NSC73306) identified in a generic screen as a compound that exploits, rather than suppresses, P-gp function to induce cytotoxicity [6].
  • While the ED2 cells showed resistance to 2,3-dihydro-1H-pyrazole-[2,3a]-imidazole/Desferal (6-fold), the ED1 and ED2 cell lines showed less resistance to hydroxyurea, 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone, and the dialdehyde of inosine [7].
  • Studies were carried out to determine the effects of preincubation of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ) with hepatic microsomes on the ability of MAIQ to inhibit CDP reductase activity in vitro [8].

Chemical compound and disease context of Thioacetazon


Biological context of Thioacetazon


Anatomical context of Thioacetazon


Associations of Thioacetazon with other chemical compounds


Gene context of Thioacetazon


Analytical, diagnostic and therapeutic context of Thioacetazon


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