Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L2FZQ 10-(4-aminobutyl)-N-(1- aminocarbonyl-2...

Synonyms: AR-1B9972, 127984-74-1, UNII-IEU56G3J9C, 108736-35-2 (Parent)

This record was replaced with 71349.

Prévost, G. et al., Agro, A. et al., Bogden, A.E. et al., Anthony, L. et al., Sciarra, A. et al.

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Disease relevance of Autogel

Twenty-seven of 30 human breast tumors (90%) had at least one BIM-23014C receptor [1].
Four human small cell lung carcinomas, NCI-H69, NCI-N417, NCI-H345, LX-1, and a non-small cell lung carcinoma, H-165, implanted s.c. as tumor xenografts in athymic nude mice, were treated with Somatuline (BIM-23014C), an endocrinologically potent octapeptide analogue of somatostatin [2].
Somatuline, (BIM 23014C, Angiopeptin, Lanreotide) was given in doses ranging from 2,250 micrograms to 9,000 micrograms daily to 13 neuroendocrine patients (6 carcinoid, 2 atypical carcinoid, 3 pancreatic islet cell and 2 small cell lung cancer patients) [3].

High impact information on Autogel

No correlation was found between receptors for BIM-23014C and epidermal growth factor in these lines [1].
Molecular heterogeneity of somatostatin analogue BIM-23014C receptors in human breast carcinoma cells using the chemical cross-linking assay [1].
On the other hand, the median progression-free survival reported in our experience using lanreotide acetate plus ethinylestradiol clearly surpassed the 10-month survival historically described in stage D3 cases [4].
We have examined the effect of somatostatin and its octapeptide analogue BIM 23014c on concanavalin A-induced lymphocyte proliferation and target-specific natural killer activity both in vitro and in vivo [5].

Anatomical context of Autogel

Immunomodulatory activities of the somatostatin analogue BIM 23014c: effects on murine lymphocyte proliferation and natural killer activity [5].

Analytical, diagnostic and therapeutic context of Autogel

Growth inhibition of MCF-7 tumor xenografts by BIM-23014C was dose related in the 6-day subrenal capsule assay [1].

References

Molecular heterogeneity of somatostatin analogue BIM-23014C receptors in human breast carcinoma cells using the chemical cross-linking assay. Prévost, G., Lanson, M., Thomas, F., Veber, N., Gonzalez, W., Beaupain, R., Starzec, A., Bogden, A. Cancer Res. (1992) [Pubmed]
Response of human lung tumor xenografts to treatment with a somatostatin analogue (Somatuline). Bogden, A.E., Taylor, J.E., Moreau, J.P., Coy, D.H., LePage, D.J. Cancer Res. (1990) [Pubmed]
Somatostatin analogue phase I trials in neuroendocrine neoplasms. Anthony, L., Johnson, D., Hande, K., Shaff, M., Winn, S., Krozely, M., Oates, J. Acta oncologica (Stockholm, Sweden) (1993) [Pubmed]
Somatostatin analogues and estrogens in the treatment of androgen ablation refractory prostate adenocarcinoma. Sciarra, A., Bosman, C., Monti, G., Gentile, V., Gomez, A.M., Ciccariello, M., Pastore, A., Salvatori, G., Fattore, F., Di Silverio, F. J. Urol. (2004) [Pubmed]
Immunomodulatory activities of the somatostatin analogue BIM 23014c: effects on murine lymphocyte proliferation and natural killer activity. Agro, A., Padol, I., Stanisz, A.M. Regul. Pept. (1991) [Pubmed]

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