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Chemical Compound Review:

Immunitin (3S,5S,8R,9S,10S,13S,14S,16R)- 16-bromo-3...

Synonyms: Inactivin, Epi-Br, Alpha-Epi-Br, PPB2, DHEA analog, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Epi-Br

16alpha-Bromoepiandrosterone restores T helper cell type 1 activity and accelerates chemotherapy-induced bacterial clearance in a model of progressive pulmonary tuberculosis [1].
In vivo, on Day 4, parasitemias decreased from 23% in the saline group to 9-12% and 12% in the in alpha-epi-Br and CQ groups, respectively (P < 0.05) [2].
Dehydroepiandrosterone (DHEA) and its analogue, 16alpha-bromoepiandrosterone (alpha-epi-Br), may have activity against viral and parasitic infections, including human immunodeficiency virus (HIV) and Cryptosporidium parvum [2].
Improvement in immune parameters and human immunodeficiency virus-1 viral response in individuals treated with 16alpha-bromoepiandrosterone (HE2000) [3].

High impact information on Epi-Br

At the highest doses tested against a CQ-sensitive strain, parasitemias decreased from 25.4% in the saline control group to 4.3% and 4.8% in the alpha-epi-Br and CQ groups, respectively (P < 0.05) [2].
Significant increases were observed in the numbers of circulating dendritic cells, early activated (CD69(+)CD25(-)) CD8 T-cells and T-NK cells after administration of 50-mg doses of HE2000 (p <0.05) [3].
A randomised, double-blind, placebo-controlled study examined the safety, tolerance, immunological effect and anti-human immunodeficiency virus (HIV) activity of sub-cutaneously administered HE2000 (16alpha-bromoepiandrosterone) as monotherapy in treatment-na??ve patients with HIV-1 [3].

Analytical, diagnostic and therapeutic context of Epi-Br

HE2000 AIDS drug shows promise in clinical trials [4].

References

16alpha-Bromoepiandrosterone restores T helper cell type 1 activity and accelerates chemotherapy-induced bacterial clearance in a model of progressive pulmonary tuberculosis. Hernández-Pando, R., Aguilar-Leon, D., Orozco, H., Serrano, A., Ahlem, C., Trauger, R., Schramm, B., Reading, C., Frincke, J., Rook, G.A. J. Infect. Dis. (2005) [Pubmed]
16alpha-bromoepiandrosterone, a dehydroepiandrosterone (DHEA) analogue, inhibits Plasmodium falciparum and Plasmodium berghei growth. Freilich, D., Ferris, S., Wallace, M., Leach, L., Kallen, A., Frincke, J., Ahlem, C., Hacker, M., Nelson, D., Hebert, J. Am. J. Trop. Med. Hyg. (2000) [Pubmed]
Improvement in immune parameters and human immunodeficiency virus-1 viral response in individuals treated with 16alpha-bromoepiandrosterone (HE2000). Reading, C., Dowding, C., Schramm, B., Garsd, A., Onizuka-Handa, N., Stickney, D., Frincke, J. Clin. Microbiol. Infect. (2006) [Pubmed]
HE2000 AIDS drug shows promise in clinical trials. Senior, K. Molecular medicine today. (2000) [Pubmed]

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