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Chemical Compound Review:

Fddguo 2-amino-9-[(2R,4S,5R)-4- fluoro-5...

Synonyms: MIV-210, SureCN914433, AG-H-79192, AC1Q6MUO, CTK5H1400, ...

Jacquard, A.C. et al., Herrström Sjöberg, A. et al., Hafkemeyer, P. et al., Löfgren, B. et al., Nakayama, T. et al., et al.

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Disease relevance of Fddguo

Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo [1].
The fluorinated guanosine analog 2',3'-dideoxy-3'-fluoroguanosine (FLG) was shown to inhibit wild-type (wt) hepatitis B virus (HBV) replication in a human hepatoma cell line permanently expressing HBV [2].
In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine [2].
A highly active form of human recombinant deoxyguanosine kinase (dGK) phosphorylated purine nucleoside analogs active against cytomegalovirus, hepatitis B virus, and human immunodeficiency virus, such as penciclovir, 2',3'-dideoxyguanosine and 3'-fluoro-2',3'-dideoxyguanosine [3].
Carbocyclic 2',3'-dideoxy-3'-fluoroguanosine (14) thus obtained was moderately active against herpes simplex virus in vitro [4].

High impact information on Fddguo

The antiviral activity of 2',3'-dideoxy-3'-fluoroguanosine (FdG) or its triphosphate was evaluated in the duck hepatitis B virus (DHBV) system in vitro and in vivo [1].
Synthesis of 6-arylthio analogs of 2',3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication [5].

Associations of Fddguo with other chemical compounds

In this study the antiviral effect of the guanosine analogue 2',3'-dideoxy-3'-fluoroguanosine (FLG) was tried in vivo on chronically DHBV-infected ducks [6].

References

Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo. Hafkemeyer, P., Keppler-Hafkemeyer, A., al Haya, M.A., von Janta-Lipinski, M., Matthes, E., Lehmann, C., Offensperger, W.B., Offensperger, S., Gerok, W., Blum, H.E. Antimicrob. Agents Chemother. (1996) [Pubmed]
In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine. Jacquard, A.C., Brunelle, M.N., Pichoud, C., Durantel, D., Carrouée-Durantel, S., Trepo, C., Zoulim, F. Antimicrob. Agents Chemother. (2006) [Pubmed]
Antiviral guanosine analogs as substrates for deoxyguanosine kinase: implications for chemotherapy. Herrström Sjöberg, A., Wang, L., Eriksson, S. Antimicrob. Agents Chemother. (2001) [Pubmed]
Regio- and stereoselective synthesis of carbocyclic 2',3'-dideoxy-3'-fluoro nucleosides as potential antiviral agents. Nakayama, T., Matsumura, Y., Morizawa, Y., Yasuda, A., Uchida, K., Takase, H., Murakami, Y., Atarashi, S., Ikeuchi, T., Osada, Y. Chem. Pharm. Bull. (1994) [Pubmed]
Synthesis of 6-arylthio analogs of 2',3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication. Torii, T., Onishi, T., Izawa, K., Maruyama, T., Demizu, Y., Neyts, J., De Clercq, E. Nucleosides Nucleotides Nucleic Acids (2006) [Pubmed]
2',3'-dideoxy-3'-fluoroguanosine inhibits duck hepatitis B virus in vivo. Löfgren, B., Vickery, K., Zhang, Y.Y., Nordenfelt, E. J. Viral Hepat. (1996) [Pubmed]

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