Disease relevance of Durene

• The order of oral toxicity was isodurene greater than prehnitene greater durene [1].

High impact information on Durene

• The reduced absorption and emission spectra of the CT complexes formed between hexamethylbenzene, pentamethylbenzene, and durene donors and 1,2,4,5-tetracyanobenzene (TCNB) in 1,2-dichloroethane (DCLE) exhibit a mirror image relationship, suggesting that each set of spectra describes transitions between the same two states [2].
• Toxic effects of acute inhalation exposure to 1,2,4,5-tetramethylbenzene (durene) in experimental animals [3].
• Oral LD50 (rat), primary skin irritation (rabbit), cutaneous sensitization (guinea pig) and eye irritation (rabbit) studies were conducted on the three tetramethylbenzene isomers: durene , isodurene and prehnitene [1].

Associations of Durene with other chemical compounds

• Neurotoxic and sensory respiratory irritation effects of 1,2,4,5-tetramethylbenzene (durene) in male rats and male Balb/C mice were investigated in the condition of acute inhalation exposure [3].

Analytical, diagnostic and therapeutic context of Durene

• The three tetramethyl isomers of benzene (prenitene, 1,2,3,4-; izodurene, 1,2,3,5-; and durene, 1,2,4,5-tetramethylben- zene) were studied using in vitro mutagenicity and in vivo genotoxicity tests [4].

References