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Chemical Compound Review:

Teridax 2-[(3-hydroxy-2,4,6-triiodo...

Synonyms: IOPHENOIC ACID, CHEMBL1551165, AC1L1OHM, LS-77190, CAS-96-84-4, ...

Bertucci, C. et al., Day, R.O. et al., Hadidian, J. et al., Eason, C.T. et al., Creekmore, T.E. et al., et al.

Bertucci, Cimitan, Creekmore, Rocke, Hurley,

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High impact information on Teridax

2. After oral administration of a single dose, the plasma elimination half-life for iopanoic acid was considerably more rapid (t1/2 of 1-2 days) than that of iophenoxic acid (t1/2 of 81 days) [1].
1. Iopanoic acid and iophenoxic acid were potent inhibitors of compound 48/80-induced histamine release from rat peritoneal cell suspensions rich in mast cells and caused a parallel dose-related reduction in ATP content of these cells [2].
No definite evidence was obtained for the highest affinity binding site of iophenoxic acid (IOPH), however, this diagnostic tool markedly affected the binding of ligands to the most characterized high affinity sites on HSA, namely sites I, II and III [3].
The biomarkers DuPont Blue dye, iophenoxic acid, and tetracycline hydrochloride were orally administered to captive prairie dogs to determine their efficacy [4].
One thousand wax-coated sponge bait cubes were filled with 5 mg of a seromarker (iophenoxic acid), placed in polyethylene bags, and hand-distributed in an 80 ha area within an urban National Park in Washington, D [5].

Anatomical context of Teridax

Six arctic foxes (Alopex lagopus) were marked with iophenoxic acid (IA), a substance which elevates concentrations of protein-bound iodine in blood plasma [6].

Analytical, diagnostic and therapeutic context of Teridax

In particular, the inhibition of drug HSA binding caused by iopanoic- and iophenoxic-acid was investigated by circular dichroism (CD) and resonant mirror (RM) optical biosensor techniques [3].

References

The plasma pharmacokinetics of iophenoxic and iopanoic acids in goat. Eason, C.T., Frampton, C.M. Xenobiotica (1992) [Pubmed]
The effect of various drugs on adenosine triphosphate content and histamine release from rat peritoneal cell suspensions rich in mast cells. Day, R.O., Wade, D.N. Clin. Exp. Pharmacol. Physiol. (1978) [Pubmed]
Inhibition of drug binding to human serum albumin by cholecystographic agents. Bertucci, C., Cimitan, S. Farmaco (2003) [Pubmed]
A baiting system for delivery of an oral plague vaccine to black-tailed prairie dogs. Creekmore, T.E., Rocke, T.E., Hurley, J. J. Wildl. Dis. (2002) [Pubmed]
Acceptance of simulated oral rabies vaccine baits by urban raccoons. Hadidian, J., Jenkins, S.R., Johnston, D.H., Savarie, P.J., Nettles, V.F., Manski, D., Baer, G.M. J. Wildl. Dis. (1989) [Pubmed]
Plasma marking of arctic foxes with iophenoxic acid. Follmann, E.H., Savarie, P.J., Ritter, D.G., Baer, G.M. J. Wildl. Dis. (1987) [Pubmed]

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