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Chemical Compound Review

Cholevid     2-[(3-amino-2,4,6-triiodo...

Synonyms: Cistobil, Copanoic, Bilijodon, Choladine, Iopagnost, ...
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Disease relevance of Telepaque


Psychiatry related information on Telepaque


High impact information on Telepaque

  • The deiodinase inhibitor iopanoic acid blocks T4- but not T3-induced cell division [7].
  • Effect of Iopanoic acid on the pituitary-thyroid axis: time sequence of changes in serum iodothyronines, thyrotropin, and prolactin concentrations and responses to thyroid hormones [8].
  • In the present study, the serum TSH concentration was increased above baseline values 5 days after the administration of 3 g iopanoic acid (IA) in five of six euthyroid volunteers (an increase of borderline significance), and the TSH response to TRH was significantly augmented after IA administration [9].
  • To investigate the relationship between serum T3 levels and thermogenesis in euthyroid subjects, the conversion of T4 to T3 was partially blocked over a period of 3 weeks by weekly ingestion of 2 g iopanoic acid [10].
  • The role of local 5'-DII was further tested by incubating brown adipocytes with 10(-6) M NE and T4 (65 x 10[-9] M) in the presence of 100 microM iopanoic acid, a potent inhibitor of 5'-DII [11].

Chemical compound and disease context of Telepaque


Biological context of Telepaque

  • The biliary and urinary excretion of iopanoic acid: pharmacokinetics, influence of bile salts, and choleretic effect. An experimental study in bile-fistula dogs [17].
  • Although iopanoic acid did not affect the T3 stimulation of lipogenesis, it did block the approximately 2-fold stimulation of lipogenesis triggered by NE in the presence of T4, confirming the mediation of 5'-DII in this process [11].
  • A series of sterol esters of iopanoic acid was synthesized and evaluated for their potential to selectively localize in liver and steroid-secreting tissues for possible application in either computed tomography or nuclear medicine imaging [18].
  • Direct evidence of the importance of the intracellular conversion of T4 to T3 for TH-dependent metamorphic events was obtained in tadpoles in which endogenous TH synthesis was blocked with methimazole, and the activities of D2 and D3 were inhibited by iopanoic acid [19].
  • For this purpose we compared the effect of amiodarone with that of another potent inhibitor of the T4----T3 conversion, i.e. the radiographic contrast medium iopanoic acid, on the heart rate of unanaesthetized guinea-pigs [20].

Anatomical context of Telepaque

  • The effect of nonfractionated and fractionated administration of iopanoic acid on gallbladder visualization [21].
  • The results demonstrate that in vitro competitive inhibitors, such as iopanoic acid, as well as iodothyronine substrates induce a rapid and irreversible loss of enzyme activity in rat cerebral cortex and anterior pituitary tissue [22].
  • We have studied the effect of iopanoic acid (IOP), a radiographic contrast agent which inhibits T4 to T3 conversion, on thyroid hormone nuclear receptors, GH response to T4 and T3, and T4 5'-monodeiodination in GH1 cells, a rat pituitary cell line [23].
  • We studied the effect of iopanoic acid (IOP), an iodinated contrast medium, on iodothyronine 5'-deiodinase (5'D) and nuclear T3 content (nT3) in fetal tissues [24].
  • We found that third ventricle administration of the deiodinase inhibitor, iopanoic acid, dose-dependently reduced deiodinase type II (DII) activity selectively in the hypothalamus [25].

Associations of Telepaque with other chemical compounds

  • Fifteen healthy volunteers underwent a randomized trial of oral cholecystography (OCG) using 5 different combinations of contrast agents given as 2 consecutive doses: Telepaque (iopanoic acid) given with food (TF) or without food (T), Bilopaque (sodium tyropanoate) given without food, and a combination of both agents (TF-B) [26].
  • A 4.5-G dose of iopronic acid produced a similar degree of gallbladder opacification as 3.0 g of iopanoic acid [27].
  • The effects of the iodine-containing radiocontrast agents ipodate, iopanoic acid, and iothalamate on the secretion of T4, T3, and rT3 were studied using perfused canine thyroid lobes [28].
  • This suppression of DII by iopanoic acid during fasting prevented elevated DII activity and blunted the decline in hypothalamic TRH mRNA levels [25].
  • T4 action was due to a direct interaction with TRalpha and not to its conversion to T3, since T4 effect persisted in the presence of 5'-deiodinase inhibitors (propylthiouracil, iopanoic acid) effectively preventing T3 generation, as assessed by the absence of T3 by HPLC in the cellular extracts of transfected cells [29].

Gene context of Telepaque

  • The GH responsiveness to GHRH was therefore evaluated in a group of hyperthyroid patients during short-term treatment with iopanoic acid [30].
  • When 5'D activity was inhibited with iopanoic acid, mRNA for UCP was reduced, while LPL activity was unaffected [31].
  • From an experiment on iopanoic acid treatment of pregnant mothers, it was concluded that iodothyronine 5'-deiodinase activity is not necessary for the expression of the mRNAs for UCP, COII and lipoprotein lipase in the fetus whereas it is necessary for the acquisition of temperature sensitivity to these parameters at birth [32].
  • Blockage by PRL of TH-induced tail regression in organ culture was released by treatment with iopanoic acid (IOP, an inhibitor of 5D activity) [33].
  • These effects of LBI were essentially the same as those of excess iodide, while other iodinated compounds including amiodarone, iopanoic acid and erythrosine had no effect on the thyroid ODC activity [34].

Analytical, diagnostic and therapeutic context of Telepaque


  1. Thrombocytopenic purpura following iopanoic acid ingestion. Hysell, J.K., Hysell, J.W., Gray, J.M. JAMA (1977) [Pubmed]
  2. Inhibition of intrapituitary thyroxine to 3.5.3'-triiodothyronine conversion prevents the acute suppression of thyrotropin release by thyroxine in hypothyroid rats. Larsen, P.R., Dick, T.E., Markovitz, B.P., Kaplan, M.M., Gard, T.G. J. Clin. Invest. (1979) [Pubmed]
  3. Effect of iopanoic acid on radioiodine therapy of hyperthyroidism: long-term outcome of a randomized controlled trial. Bal, C.S., Kumar, A., Chandra, P. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  4. Treatment of type II amiodarone-induced thyrotoxicosis by either iopanoic acid or glucocorticoids: a prospective, randomized study. Bogazzi, F., Bartalena, L., Cosci, C., Brogioni, S., Dell'Unto, E., Grasso, L., Aghini-Lombardi, F., Rossi, G., Pinchera, A., Braverman, L.E., Martino, E. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  5. Long term treatment of Graves' disease with iopanoic acid (Telepaque). Wang, Y.S., Tsou, C.T., Lin, W.H., Hershman, J.M. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  6. Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging. Nguyen, T.T., Pannu, Y.S., Sung, C., Dedrick, R.L., Walbridge, S., Brechbiel, M.W., Garmestani, K., Beitzel, M., Yordanov, A.T., Oldfield, E.H. J. Neurosurg. (2003) [Pubmed]
  7. Expression of type II iodothyronine deiodinase marks the time that a tissue responds to thyroid hormone-induced metamorphosis in Xenopus laevis. Cai, L., Brown, D.D. Dev. Biol. (2004) [Pubmed]
  8. Effect of Iopanoic acid on the pituitary-thyroid axis: time sequence of changes in serum iodothyronines, thyrotropin, and prolactin concentrations and responses to thyroid hormones. Suzuki, H., Noguchi, K., Nakahata, M., Nakagawa, S., Kadena, N. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  9. The effect of iopanoic acid on the regulation of thyrotropin secretion in euthyroid subjects. Kleinmann, R.E., Vagenakis, A.G., Braverman, L.E. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  10. A study of the relationship between thermogenesis and thyroid hormones. Acheson, K.J., Burger, A.G. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  11. Thyroxine 5'-deiodination mediates norepinephrine-induced lipogenesis in dispersed brown adipocytes. Bianco, A.C., Carvalho, S.D., Carvalho, C.R., Rabelo, R., Moriscot, A.S. Endocrinology (1998) [Pubmed]
  12. Expression of type II thyroxine 5'-deiodinase from rat harderian gland in Xenopus laevis oocytes. Garcia-Macias, J.F., Molinero, P., Guerrero, J.M., Osuna, C. FEBS Lett. (1994) [Pubmed]
  13. Oral cholecystography in the early phase of acute alcoholic pancreatitis. A prospective, randomized comparison of Telepaque and Bilopaque. Smith, H.J., Corbett, D.B., Loeb, P.M., Peterson, W.L. Investigative radiology. (1982) [Pubmed]
  14. Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. Cardoso, L.C., Martins, D.C., Campos, D.V., Santos, L.M., Corrêa da Costa, V.M., Rosenthal, D., Vaisman, M., Violante, A.H., Carvalho, D.P. Eur. J. Endocrinol. (2002) [Pubmed]
  15. Iopanoic acid as an adjunct to carbimazole in the management of hyperthyroidism. Gupta, S.K., Mithal, A., Godbole, M.M. The National medical journal of India. (1992) [Pubmed]
  16. Clinical comparison of two contrast agents for oral cholecystography: radiologic efficacy and drug safety of iopanoic acid and iopronic acid. Hedlund, L., Putman, C.E., Burrell, M. The Yale journal of biology and medicine. (1979) [Pubmed]
  17. The biliary and urinary excretion of iopanoic acid: pharmacokinetics, influence of bile salts, and choleretic effect. An experimental study in bile-fistula dogs. Berk, R.N., Loeb, P.M., Cobo-Frenkel, A., Barnhart, J.L. Radiology. (1976) [Pubmed]
  18. Potential tumor- or organ-imaging agents. 23. Sterol esters of iopanoic acid. Seevers, R.H., Groziak, M.P., Weichert, J.P., Schwendner, S.W., Szabo, S.M., Longino, M.A., Counsell, R.E. J. Med. Chem. (1982) [Pubmed]
  19. The type 2 and type 3 iodothyronine deiodinases play important roles in coordinating development in Rana catesbeiana tadpoles. Becker, K.B., Stephens, K.C., Davey, J.C., Schneider, M.J., Galton, V.A. Endocrinology (1997) [Pubmed]
  20. Does amiodarone affect heart rate by inhibiting the intracellular generation of triiodothyronine from thyroxine? Lindenmeyer, M., Spörri, S., Stäubli, M., Studer, A., Studer, H. Br. J. Pharmacol. (1984) [Pubmed]
  21. The effect of nonfractionated and fractionated administration of iopanoic acid on gallbladder visualization. Nehen, A.M., Kruse, V. Radiology. (1978) [Pubmed]
  22. The effects and interactions of substrates, inhibitors, and the cellular thiol-disulfide balance on the regulation of type II iodothyronine 5'-deiodinase. St Germain, D.L. Endocrinology (1988) [Pubmed]
  23. Effects of iopanoic acid on thyroid hormone receptor, growth hormone production, and triiodothyronine generation from thyroxine in pituitary GH1 cells. Pascual, A., Montiel, F., Aranda, A. Endocrinology (1987) [Pubmed]
  24. Inhibition of iodothyronine 5'-deiodinase by iopanoic acid does not block nuclear T3 accumulation during rat fetal development. Tuca, A., Giralt, M., Villarroya, F., Viñas, O., Mampel, T., Iglesias, R. Pediatr. Res. (1994) [Pubmed]
  25. Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting. Coppola, A., Hughes, J., Esposito, E., Schiavo, L., Meli, R., Diano, S. FEBS Lett. (2005) [Pubmed]
  26. A clinical trial of oral cholecystography using combinations of contrast agents and two consecutive doses. Thoeni, R.F., Moss, A.A. Radiology. (1982) [Pubmed]
  27. Comparison of oral cholecystopaques: iopronic acid vs. iopanoic acid. Amberg, J.R., Goldberger, L.A., Bates, M. Radiology. (1980) [Pubmed]
  28. The effect of some iodine-containing radiocontrast agents on iodothyronine secretion from the perfused canine thyroid. Laurberg, P. Endocrinology (1982) [Pubmed]
  29. L-thyroxine directly affects expression of thyroid hormone-sensitive genes: regulatory effect of RXRbeta. Bogazzi, F., Bartalena, L., Brogioni, S., Burelli, A., Grasso, L., Dell'Unto, E., Manetti, L., Martino, E. Mol. Cell. Endocrinol. (1997) [Pubmed]
  30. Iopanoic acid-induced decrease of circulating T3 causes a significant increase in GH responsiveness to GH releasing hormone in thyrotoxic patients. Ramos-Dias, J.C., Lengyel, A.M. Clin. Endocrinol. (Oxf) (1999) [Pubmed]
  31. Inhibition of 5'-deiodination of thyroxine suppresses the cold-induced increase in brown adipose tissue messenger ribonucleic acid for mitochondrial uncoupling protein without influencing lipoprotein lipase activity. Reiter, R.J., Klaus, S., Ebbinghaus, C., Heldmaier, G., Redlin, U., Ricquier, D., Vaughan, M.K., Steinlechner, S. Endocrinology (1990) [Pubmed]
  32. Ontogeny and perinatal modulation of gene expression in rat brown adipose tissue. Unaltered iodothyronine 5'-deiodinase activity is necessary for the response to environmental temperature at birth. Giralt, M., Martin, I., Iglesias, R., Viñas, O., Villarroya, F., Mampel, T. Eur. J. Biochem. (1990) [Pubmed]
  33. Tissue-specific regulation of type III iodothyronine 5-deiodinase gene expression mediates the effects of prolactin and growth hormone in Xenopus metamorphosis. Shintani, N., Nohira, T., Hikosaka, A., Kawahara, A. Dev. Growth Differ. (2002) [Pubmed]
  34. Anti-goitrous effect of lecithin-bound iodine in propylthiouracil treated rats. Matsuzaki, S., Ma, H.T., Burikhanov, R.B. Endocrine regulations. (2000) [Pubmed]
  35. Inhibitory effect of iopanoic acid on the thyrotropin-stimulated release of cyclic adenosine 3',5'-monophosphate and of 3,5,3'-triiodothyronine from perifused rat thyroids. Tajima, K., Mashita, K., Shimizu, M., Tarui, S. Endocrinology (1985) [Pubmed]
  36. Helical CT cholangiography with oral cholecystographic contrast material. Chopra, S., Chintapalli, K.N., Ramakrishna, K., Rhim, H., Dodd, G.D. Radiology. (2000) [Pubmed]
  37. Optimal perfusion rate determined for in situ intestinal absorption studies in rats. Savina, P.M., Staubus, A.E., Gaginella, T.S., Smith, D.F. Journal of pharmaceutical sciences. (1981) [Pubmed]
  38. Preparation with iopanoic acid rapidly controls thyrotoxicosis in patients with amiodarone-induced thyrotoxicosis before thyroidectomy. Bogazzi, F., Miccoli, P., Berti, P., Cosci, C., Brogioni, S., Aghini-Lombardi, F., Materazzi, G., Bartalena, L., Pinchera, A., Braverman, L.E., Martino, E. Surgery (2002) [Pubmed]
  39. Physical characterization of solid iopanoic acid forms. Stagner, W.C., Guillory, J.K. Journal of pharmaceutical sciences. (1979) [Pubmed]
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