High impact information on NSC 9812

• Cytochrome b5 specifically augmented the deethylation of p-nitrophenetole in microsomal membrane fractions of infected cells or when substrate was incubated directly with cells in situ [1].
• Different requirement for cytochrome b5 in NADPH-supported O-deethylation of p-nitrophenetole catalyzed by two types of microsomal cytochrome P-450 [2].
• NADH-dependent O-deethylation of p-nitrophenetole with rabbit liver microsomes [3].
• 3. For p-nitrophenetole O-deethylation, the cutaneous Vmax is 3.8% of the hepatic Vmax on a mg protein basis [4].
• Possible role of cytochrome P-448 in the O-deethylation of p-nitrophenetole by rat liver microsomes [5].

Biological context of NSC 9812

• Novikoff kepatoma microsomes catalyze the hydroxylation of benzphetamine and ethylmorphine at rates less than 1% of those of liver microsomes but catalyze the hydroxylation of p-nitroanisole and p-nitrophenetole at rates about 40% of those of liver microsomes [6].

Anatomical context of NSC 9812

• A comparative analysis of the deethylase activity against p-nitrophenetole by encapsulated and freely suspended microsomes is carried out [7].

Associations of NSC 9812 with other chemical compounds

• The rate of conversion of p-nitrophenetole to p-nitrophenol by rat liver microsomes was studied [8].
• 1. Activities of hepatic monooxygenase systems (aminopyrine N-demethylase, benzo[a]pyrene hydroxylase and p-nitrophenetole O-deethylase) of the brown trout (Salmo trutta), leopard frog (Rana pipiens) and garter snake (Thamnophis) were observed to be considerably lower than those of the rat [9].

Gene context of NSC 9812

• 1. 3-Methylcholanthrene administration increased levels of cytochrome P-450, benzo[a]pyrene hydroxylase activity and p-nitrophenetole O-deethylase activity in hepatic microsomes from the brown trout (Salmo trutta), leopard frog (Rana pipiens) and the garter snake (Thamnophis) [10].

References