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Chemical Compound Review

SureCN23596     [4-[bis(4-diethylaminophenyl) methylidene]n...

Synonyms: NSC-51534, Basic blue 7, AC1L2ORR, NSC51534, SBB057293, ...
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Disease relevance of 4-[(4-diethylaminophenyl)-(4-ethyliminonaphthalen-1-ylidene)methyl]-N,N-diethyl-aniline

  • Inhibition of respiratory enzymes is thus only a minor component of Photofrin-mediated (long incubation) phototoxicity in these cell lines and is overwhelmed by more significant damage elsewhere, whereas it is a major but not the exclusive element of death mediated by VBBO [1].

High impact information on 4-[(4-diethylaminophenyl)-(4-ethyliminonaphthalen-1-ylidene)methyl]-N,N-diethyl-aniline


Biological context of 4-[(4-diethylaminophenyl)-(4-ethyliminonaphthalen-1-ylidene)methyl]-N,N-diethyl-aniline

  • Consistent with a mitochondrial localization of VBBO and independence from respiratory-chain damage, ET3 cells were less susceptible than 2008 to both dark- and light-activated VBBO-mediated damage [1].

Associations of 4-[(4-diethylaminophenyl)-(4-ethyliminonaphthalen-1-ylidene)methyl]-N,N-diethyl-aniline with other chemical compounds


  1. Comparison of photodynamic targets in a carcinoma cell line and its mitochondrial DNA-deficient derivative. Morgan, J., Potter, W.R., Oseroff, A.R. Photochem. Photobiol. (2000) [Pubmed]
  2. Mitochondrial toxicity of cationic photosensitizers for photochemotherapy. Modica-Napolitano, J.S., Joyal, J.L., Ara, G., Oseroff, A.R., Aprille, J.R. Cancer Res. (1990) [Pubmed]
  3. Cytotoxicity and adjuvant activity of cationic photosensitizers in a multidrug resistant cell line. Wainwright, M., Phoenix, D.A., Burrow, S.M., Waring, J. Journal of chemotherapy (Florence, Italy) (1999) [Pubmed]
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