The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Toluidine Blue     (7-amino-8-methyl- phenothiazin-3-ylidene)...

Synonyms: Tolonium, Blutene, Gabilin, Menodin, Tolazul, ...
This record was replaced with 7084.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Toluidine Blue


Psychiatry related information on Toluidine Blue


High impact information on Toluidine Blue

  • To assess whether a recently developed indirect immunofluorescent stain using monoclonal antibodies was more sensitive than Giemsa or toluidine blue O stains in detecting P. carinii in sputum, we undertook two prospective studies [10].
  • Tolonium chloride (toluidine blue) application is useful for identifying malignant changes in squamous mucosa [1].
  • By week 9, the cells had matured into hMCs, identified by higher levels of c-kit, continued expression of CD13 and low-level FcinRIalpha, uniform toluidine blue metachromasia, and uniform immunoreactivity for both tryptase and chymase [11].
  • Of the nonadherent cells, 93 +/- 1% contained cyanide-resistant peroxidase, and 88 +/- 2% were toluidine blue-positive, characteristic of eosinophil and basophil granules, respectively [12].
  • The cultured basophil-like cells had lobulated or round nuclei, and the cytoplasmic granules stained metachromatically with toluidine blue and azurophilic with Giemsa [13].

Chemical compound and disease context of Toluidine Blue


Biological context of Toluidine Blue


Anatomical context of Toluidine Blue


Associations of Toluidine Blue with other chemical compounds


Gene context of Toluidine Blue


Analytical, diagnostic and therapeutic context of Toluidine Blue


  1. Tolonium (toluidine blue) rinse--a screening method for recognition of squamous carcinoma. Continuing study of oral cancer IV. Mashberg, A. JAMA (1981) [Pubmed]
  2. The question of a helminthic cause of preeclampsia. Richards, F.O., Grimes, D.A., Wilson, M. JAMA (1983) [Pubmed]
  3. DNA content of liver cell nuclei of N-2-fluorenylacetamide-induced altered foci and neoplasms in rats and human hyperplastic foci. Mori, H., Tanaka, T., Sugie, S., Takahashi, M., Williams, G.M. J. Natl. Cancer Inst. (1982) [Pubmed]
  4. Dermatoglyphic analysis of fetuses with chromosomal abnormalities. Suzumori, K. Am. J. Hum. Genet. (1980) [Pubmed]
  5. Basophils (Bsp-1+) derive from the leukemic clone in human myeloid leukemias involving the chromosome breakpoint 9q34. Bodger, M.P., Morris, C.M., Kennedy, M.A., Bowen, J.A., Hilton, J.M., Fitzgerald, P.H. Blood (1989) [Pubmed]
  6. Transient, learning-induced ultrastructural change in spatially-clustered dentate granule cells of the adult rat hippocampus. O'Connell, C., O'Malley, A., Regan, C.M. Neuroscience (1997) [Pubmed]
  7. Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos. Roy, T.S., Andrews, J.E., Seidler, F.J., Slotkin, T.A. Teratology (1998) [Pubmed]
  8. The use of diagnostic tests to aid clinical diagnosis. Matthews, D.C., Banting, D.W., Bohay, R.N. Journal (Canadian Dental Association) (1995) [Pubmed]
  9. Abnormal mitochondria in hepatocytes in human fatty liver. Petersen, P. Acta pathologica et microbiologica Scandinavica. Section A, Pathology. (1977) [Pubmed]
  10. Diagnosis of Pneumocystis carinii pneumonia: improved detection in sputum with use of monoclonal antibodies. Kovacs, J.A., Ng, V.L., Masur, H., Leoung, G., Hadley, W.K., Evans, G., Lane, H.C., Ognibene, F.P., Shelhamer, J., Parrillo, J.E. N. Engl. J. Med. (1988) [Pubmed]
  11. T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. Ochi, H., Hirani, W.M., Yuan, Q., Friend, D.S., Austen, K.F., Boyce, J.A. J. Exp. Med. (1999) [Pubmed]
  12. Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate. Boyce, J.A., Friend, D., Matsumoto, R., Austen, K.F., Owen, W.F. J. Exp. Med. (1995) [Pubmed]
  13. Factor-dependent in vitro growth of human normal bone marrow-derived basophil-like cells. Tadokoro, K., Stadler, B.M., De Weck, A.L. J. Exp. Med. (1983) [Pubmed]
  14. Relaxation of supercoiled plasmid DNA by oxidative stresses in Escherichia coli. Horiuchi, H., Takagi, M., Yano, K. J. Bacteriol. (1984) [Pubmed]
  15. Susceptibility of Streptococcus mutans biofilms to photodynamic therapy: an in vitro study. Zanin, I.C., Gonçalves, R.B., Junior, A.B., Hope, C.K., Pratten, J. J. Antimicrob. Chemother. (2005) [Pubmed]
  16. Cellulose acetate containing toluidine blue and rose bengal is an effective antimicrobial coating when exposed to white light. Decraene, V., Pratten, J., Wilson, M. Appl. Environ. Microbiol. (2006) [Pubmed]
  17. Gene responsible for protecting Escherichia coli from sodium dodecyl sulfate and toluidine blue plus light. Wakayama, Y., Takagi, M., Yano, K. J. Bacteriol. (1984) [Pubmed]
  18. Effect of Ca(+) on the photobactericidal efficacy of methylene blue and toluidine blue against gram-negative bacteria and the dye affinity for lipopolysaccharides. Usacheva, M.N., Teichert, M.C., Sievert, C.E., Biel, M.A. Lasers in surgery and medicine (2006) [Pubmed]
  19. A diastrophic dysplasia sulfate transporter (SLC26A2) mutant mouse: morphological and biochemical characterization of the resulting chondrodysplasia phenotype. Forlino, A., Piazza, R., Tiveron, C., Della Torre, S., Tatangelo, L., Bonafè, L., Gualeni, B., Romano, A., Pecora, F., Superti-Furga, A., Cetta, G., Rossi, A. Hum. Mol. Genet. (2005) [Pubmed]
  20. Toluidine blue staining identifies high-risk primary oral premalignant lesions with poor outcome. Zhang, L., Williams, M., Poh, C.F., Laronde, D., Epstein, J.B., Durham, S., Nakamura, H., Berean, K., Hovan, A., Le, N.D., Hislop, G., Priddy, R., Hay, J., Lam, W.L., Rosin, M.P. Cancer Res. (2005) [Pubmed]
  21. Morphometric study of the rat duodenal epithelium during the initial six months of 1,2-dimethylhydrazine carcinogenesis. Snow, A.D., Altmann, G.G. Cancer Res. (1983) [Pubmed]
  22. Programmed cell death during Drosophila embryogenesis. Abrams, J.M., White, K., Fessler, L.I., Steller, H. Development (1993) [Pubmed]
  23. Photosensitizing effects of the tricyclic heteroaromatic cationic dyes pyronin Y and toluidine blue O (tolonium chloride). Darzynkiewicz, Z., Carter, S.P. Cancer Res. (1988) [Pubmed]
  24. Inflammatory component of celiac sprue mucosa. I. Mast cells, basophils, and eosinophils. Marsh, M.N., Hinde, J. Gastroenterology (1985) [Pubmed]
  25. Intralysosomal accumulation of polyanions. I. Fusion of pinocytic and phagocytic vacuoles with secondary lysosomes. Kielian, M.C., Steinman, R.M., Cohn, Z.A. J. Cell Biol. (1982) [Pubmed]
  26. Increase and redistribution of cardiac mast cells in auricular thrombosis. Possible role of kit ligand. Bankl, H.C., Radaszkiewicz, T., Klappacher, G.W., Glogar, D., Sperr, W.R., Grossschmidt, K., Bankl, H., Lechner, K., Valent, P. Circulation (1995) [Pubmed]
  27. Transplantation of fetal myocardial tissue into the infarcted myocardium of rat. A potential method for repair of infarcted myocardium? Leor, J., Patterson, M., Quinones, M.J., Kedes, L.H., Kloner, R.A. Circulation (1996) [Pubmed]
  28. Clonal analysis of basophil differentiation in bone marrow cultures from a Down's syndrome patient with megakaryoblastic leukemia. Suda, T., Suda, J., Miura, Y., Hayashi, Y., Eguchi, M., Tadokoro, K., Saito, M. Blood (1985) [Pubmed]
  29. The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability. Conrad, M., Moreno, S.G., Sinowatz, F., Ursini, F., Kölle, S., Roveri, A., Brielmeier, M., Wurst, W., Maiorino, M., Bornkamm, G.W. Mol. Cell. Biol. (2005) [Pubmed]
  30. Metabolic and ultrastructural changes in articular cartilage of rats fed dietary supplements of omega-3 fatty acids. Lippiello, L., Fienhold, M., Grandjean, C. Arthritis Rheum. (1990) [Pubmed]
  31. Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. Verborgt, O., Gibson, G.J., Schaffler, M.B. J. Bone Miner. Res. (2000) [Pubmed]
  32. Epithelial desquamation in asthma: artifact or pathology? Ordoñez, C., Ferrando, R., Hyde, D.M., Wong, H.H., Fahy, J.V. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  33. Myelin basic protein and myelin-associated glycoprotein in chronic, relapsing experimental allergic encephalomyelitis. Sternberger, N.H., McFarlin, D.E., Traugott, U., Raine, C.S. J. Neuroimmunol. (1984) [Pubmed]
  34. The expression of c-kit protein in human adult and fetal tissues. Horie, K., Fujita, J., Takakura, K., Kanzaki, H., Suginami, H., Iwai, M., Nakayama, H., Mori, T. Hum. Reprod. (1993) [Pubmed]
  35. Hyaline cartilage formation and enchondral ossification modeled with KUM5 and OP9 chondroblasts. Sugiki, T., Uyama, T., Toyoda, M., Morioka, H., Kume, S., Miyado, K., Matsumoto, K., Saito, H., Tsumaki, N., Takahashi, Y., Toyama, Y., Umezawa, A. J. Cell. Biochem. (2007) [Pubmed]
  36. Granular acute lymphoblastic leukemia with hypereosinophilic syndrome. Jain, P., Kumar, R., Gujral, S., Kumar, A., Singh, A., Jain, Y., Dubey, S., Anand, M., Arya, L.S. Ann. Hematol. (2000) [Pubmed]
  37. Enhancement of toluidine blue staining by transforming growth factor-beta, insulin-like growth factor and growth hormone in the temporomandibular joint of aged mice. Blumenfeld, I., Gaspar, R., Laufer, D., Livne, E. Cells Tissues Organs (Print) (2000) [Pubmed]
  38. Improved diagnosis of Pneumocystis carinii infection by polymerase chain reaction on induced sputum and blood. Lipschik, G.Y., Gill, V.J., Lundgren, J.D., Andrawis, V.A., Nelson, N.A., Nielsen, J.O., Ognibene, F.P., Kovacs, J.A. Lancet (1992) [Pubmed]
  39. Clonal assay of mouse mast cell colonies in methylcellulose culture. Nakahata, T., Spicer, S.S., Cantey, J.R., Ogawa, M. Blood (1982) [Pubmed]
  40. Fibroblasts induce heparin synthesis in chondroitin sulfate E containing human bone marrow-derived mast cells. Gilead, L., Bibi, O., Razin, E. Blood (1990) [Pubmed]
  41. Intramuscular injection of hrRANTES causes mast cell recruitment and increased transcription of histidine decarboxylase in mice: lack of effects in genetically mast cell-deficient W/WV mice. Conti, P., Reale, M., Barbacane, R.C., Letourneau, R., Theoharides, T.C. FASEB J. (1998) [Pubmed]
WikiGenes - Universities