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MeSH Review


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Disease relevance of Photochemotherapy


High impact information on Photochemotherapy


Chemical compound and disease context of Photochemotherapy


Biological context of Photochemotherapy


Anatomical context of Photochemotherapy


Associations of Photochemotherapy with chemical compounds

  • RESULTS: After photodynamic therapy, bilirubin serum levels declined from 318 +/- 72 to 103 +/- 35 micromol/L (P = 0.0039) with no significant increase during the two monthly follow-ups [4].
  • Selective necrosis in dimethylhydrazine-induced rat colon tumors using phthalocyanine photodynamic therapy [26].
  • The recent successful introduction of photochemotherapy (psoralen and ultraviolet light) for moderate and severely affected psoriatics will probably lead to a substantial decrease in the number of patients requiring methotrexate [27].
  • Based on these findings, we conclude that IFN plus oral photochemotherapy is superior to IFN plus acitretin, inducing more complete remissions in patients with CTCL stages I and II [28].
  • Adjunct medical treatments, aimed at containing the virus and growth of tumours, include indole-3-carbinol or its dimer diindolylmethane, interferon, photodynamic therapy and others [29].

Gene context of Photochemotherapy


Analytical, diagnostic and therapeutic context of Photochemotherapy


  1. Nuclear magnetic resonance spectroscopy and sensitizer-adduct measurements of photodynamic therapy-induced ischemia in solid tumors. Chapman, J.D., McPhee, M.S., Walz, N., Chetner, M.P., Stobbe, C.C., Soderlind, K., Arnfield, M., Meeker, B.E., Trimble, L., Allen, P.S. J. Natl. Cancer Inst. (1991) [Pubmed]
  2. Dithranol or photochemotherapy for psoriasis? Howell, D.R. Lancet (1979) [Pubmed]
  3. Double-blind, controlled, crossover study of cyclosporin in adults with severe refractory atopic dermatitis. Sowden, J.M., Berth-Jones, J., Ross, J.S., Motley, R.J., Marks, R., Finlay, A.Y., Salek, M.S., Graham-Brown, R.A., Allen, B.R., Camp, R.D. Lancet (1991) [Pubmed]
  4. Photodynamic therapy of nonresectable cholangiocarcinoma. Ortner, M.A., Liebetruth, J., Schreiber, S., Hanft, M., Wruck, U., Fusco, V., Müller, J.M., Hörtnagl, H., Lochs, H. Gastroenterology (1998) [Pubmed]
  5. Inhibition of delayed hypersensitivity reaction in skin (DNCB test) by 8-methoxypsoralen photochemotherapy. Possible basis for pseudo-promoting action in skin carcinogenesis? Strauss, G.H., Bridges, B.A., Greaves, M., Hall-Smith, P., Price, M., Vella-Briffa, D. Lancet (1980) [Pubmed]
  6. Photodynamic therapy with hematoporphyrin derivative in the treatment of superficial transitional-cell carcinoma of the bladder. Prout, G.R., Lin, C.W., Benson, R., Nseyo, U.O., Daly, J.J., Griffin, P.P., Kinsey, J., Tian, M.E., Lao, Y.H., Mian, Y.Z. N. Engl. J. Med. (1987) [Pubmed]
  7. Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications. Döring, F., Walter, J., Will, J., Föcking, M., Boll, M., Amasheh, S., Clauss, W., Daniel, H. J. Clin. Invest. (1998) [Pubmed]
  8. Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases. Smith, G., Wolf, C.R., Deeni, Y.Y., Dawe, R.S., Evans, A.T., Comrie, M.M., Ferguson, J., Ibbotson, S.H. Lancet (2003) [Pubmed]
  9. Eradication of high-grade dysplasia in columnar-lined (Barrett's) oesophagus by photodynamic therapy with endogenously generated protoporphyrin IX. Barr, H., Shepherd, N.A., Dix, A., Roberts, D.J., Tan, W.C., Krasner, N. Lancet (1996) [Pubmed]
  10. Intraluminal treatment of inoperable oesophageal tumours by intralesional photodynamic therapy with methylene blue. Orth, K., Rück, A., Stanescu, A., Beger, H.G. Lancet (1995) [Pubmed]
  11. Effectiveness of delta-aminolevulinic acid-induced protoporphyrin as a photosensitizer for photodynamic therapy in vivo. Hua, Z., Gibson, S.L., Foster, T.H., Hilf, R. Cancer Res. (1995) [Pubmed]
  12. IL-10 contributes to the inhibition of contact hypersensitivity in mice treated with photodynamic therapy. Simkin, G.O., Tao, J.S., Levy, J.G., Hunt, D.W. J. Immunol. (2000) [Pubmed]
  13. Photodynamic therapy in the canine prostate using motexafin lutetium. Hsi, R.A., Kapatkin, A., Strandberg, J., Zhu, T., Vulcan, T., Solonenko, M., Rodriguez, C., Chang, J., Saunders, M., Mason, N., Hahn, S. Clin. Cancer Res. (2001) [Pubmed]
  14. Intravitreal triamcinolone acetonide for treatment of intraocular proliferative, exudative, and neovascular diseases. Jonas, J.B., Kreissig, I., Degenring, R. Progress in retinal and eye research. (2005) [Pubmed]
  15. Photodynamic therapy of pigmented choroidal melanomas. Gonzalez, V.H., Hu, L.K., Theodossiadis, P.G., Flotte, T.J., Gragoudas, E.S., Young, L.H. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  16. Targeting PBR by hexaminolevulinate-mediated photodynamic therapy induces apoptosis through translocation of apoptosis-inducing factor in human leukemia cells. Furre, I.E., Shahzidi, S., Luksiene, Z., Møller, M.T., Borgen, E., Morgan, J., Tkacz-Stachowska, K., Nesland, J.M., Peng, Q. Cancer Res. (2005) [Pubmed]
  17. Phase I and pharmacokinetic study of photodynamic therapy for high-grade gliomas using a novel boronated porphyrin. Rosenthal, M.A., Kavar, B., Hill, J.S., Morgan, D.J., Nation, R.L., Stylli, S.S., Basser, R.L., Uren, S., Geldard, H., Green, M.D., Kahl, S.B., Kaye, A.H. J. Clin. Oncol. (2001) [Pubmed]
  18. De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells. Dolgachev, V., Farooqui, M.S., Kulaeva, O.I., Tainsky, M.A., Nagy, B., Hanada, K., Separovic, D. J. Biol. Chem. (2004) [Pubmed]
  19. Downregulation of ICAM-1 and VCAM-1 expression in endothelial cells treated by photodynamic therapy. Volanti, C., Gloire, G., Vanderplasschen, A., Jacobs, N., Habraken, Y., Piette, J. Oncogene (2004) [Pubmed]
  20. Ascorbic acid suppresses cell death in rat DS-sarcoma cancer cells induced by 5-aminolevulinic acid-based photodynamic therapy. Frank, J., Flaccus, A., Schwarz, C., Lambert, C., Biesalski, H.K. Free Radic. Biol. Med. (2006) [Pubmed]
  21. Photodynamic therapy for obstructing esophageal cancer: light dosimetry and randomized comparison with Nd:YAG laser therapy. Heier, S.K., Rothman, K.A., Heier, L.M., Rosenthal, W.S. Gastroenterology (1995) [Pubmed]
  22. Lack of reciprocity in drug and light dose dependence of photodynamic therapy of pancreatic adenocarcinoma in vitro. Moesta, K.T., Greco, W.R., Nurse-Finlay, S.O., Parsons, J.C., Mang, T.S. Cancer Res. (1995) [Pubmed]
  23. Photodynamic therapy induces caspase-3 activation in HL-60 cells. Granville, D.J., Levy, J.G., Hunt, D.W. Cell Death Differ. (1997) [Pubmed]
  24. Photodynamic therapy for advanced bile duct cancer: evidence for improved palliation and extended survival. Berr, F., Wiedmann, M., Tannapfel, A., Halm, U., Kohlhaw, K.R., Schmidt, F., Wittekind, C., Hauss, J., Mössner, J. Hepatology (2000) [Pubmed]
  25. Histological study of the effect of hematoporphyrin derivative photodynamic therapy on the rat jejunum. Chaudhuri, K., Goldblatt, P.J., Kreimer-Birnbaum, M., Keck, R.W., Selman, S.H. Cancer Res. (1986) [Pubmed]
  26. Selective necrosis in dimethylhydrazine-induced rat colon tumors using phthalocyanine photodynamic therapy. Barr, H., Tralau, C.J., Boulos, P.B., MacRobert, A.J., Krasner, N., Phillips, D., Bown, S.G. Gastroenterology (1990) [Pubmed]
  27. Methotrexate. Weinstein, G.D. Ann. Intern. Med. (1977) [Pubmed]
  28. Prospective randomized multicenter clinical trial on the use of interferon -2a plus acitretin versus interferon -2a plus PUVA in patients with cutaneous T-cell lymphoma stages I and II. Stadler, R., Otte, H.G., Luger, T., Henz, B.M., Kühl, P., Zwingers, T., Sterry, W. Blood (1998) [Pubmed]
  29. Therapy for recurrent respiratory papillomatosis. Auborn, K.J. Antivir. Ther. (Lond.) (2002) [Pubmed]
  30. Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy. Tong, Z., Singh, G., Rainbow, A.J. Cancer Res. (2002) [Pubmed]
  31. Inhibition of cyclooxygenase-2 indirectly potentiates antitumor effects of photodynamic therapy in mice. Makowski, M., Grzela, T., Niderla, J., ŁAzarczyk, M., Mróz, P., Kopeé, M., Legat, M., Strusińska, K., Koziak, K., Nowis, D., Mrówka, P., Wasik, M., Jakóbisiak, M., Gołab, J. Clin. Cancer Res. (2003) [Pubmed]
  32. Influence of photodynamic therapy on expression of vascular endothelial growth factor (VEGF), VEGF receptor 3, and pigment epithelium-derived factor. Schmidt-Erfurth, U., Schlötzer-Schrehard, U., Cursiefen, C., Michels, S., Beckendorf, A., Naumann, G.O. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  33. Involvement of Fas (APO-1/CD-95) during photodynamic-therapy-mediated apoptosis in human epidermoid carcinoma A431 cells. Ahmad, N., Gupta, S., Feyes, D.K., Mukhtar, H. J. Invest. Dermatol. (2000) [Pubmed]
  34. Photodynamic therapy of DNA mismatch repair-deficient and -proficient tumour cells. Schwarz, V.A., Hornung, R., Fedier, A., Fehr, M.K., Walt, H., Haller, U., Fink, D. Br. J. Cancer (2002) [Pubmed]
  35. Antitumor effect of 5-aminolevulinic acid-mediated photodynamic therapy can be enhanced by the use of a low dose of photofrin in human tumor xenografts. Peng, Q., Warloe, T., Moan, J., Godal, A., Apricena, F., Giercksky, K.E., Nesland, J.M. Cancer Res. (2001) [Pubmed]
  36. Blood flow in transplantable bladder tumors treated with hematoporphyrin derivative and light. Selman, S.H., Kreimer-Birnbaum, M., Klaunig, J.E., Goldblatt, P.J., Keck, R.W., Britton, S.L. Cancer Res. (1984) [Pubmed]
  37. Potentiation of photodynamic therapy-elicited antitumor response by localized treatment with granulocyte-macrophage colony-stimulating factor. Krosl, G., Korbelik, M., Krosl, J., Dougherty, G.J. Cancer Res. (1996) [Pubmed]
  38. Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors. Dong, D., Dubeau, L., Bading, J., Nguyen, K., Luna, M., Yu, H., Gazit-Bornstein, G., Gordon, E.M., Gomer, C., Hall, F.L., Gambhir, S.S., Lee, A.S. Hum. Gene Ther. (2004) [Pubmed]
  39. Dendrimers and dendritic polymers in drug delivery. Gillies, E.R., Fréchet, J.M. Drug Discov. Today (2005) [Pubmed]
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