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Chemical Compound Review

Genoface     3-(4-chlorophenyl)-1-(3,4- dichlorophenyl)urea

Synonyms: Cusiter, Cutisan, Procutene, Solubacter, Trilocarban, ...
 
 
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Disease relevance of TCC Soap

  • After adjustment for household clustering and covariates, the incidence of impetigo among children living in households receiving triclocarban-containing soap (1.10 episodes per 100 person-weeks) was 23% lower than in households receiving placebo soap (P = 0.28) and 43% lower than the standard habit and practice controls (P = 0.02) [1].
  • The metabolism and toxicity of halogenated carbanilides. Biliary metabolites of 3,4,4'-trichlorocarbanilide and 3-trifluoromethyl-4,4'-dichlorocarbanilide in the rat [2].
  • In our new method prewashed and softened commercial deodorant soap bars (0.8% triclocarban) not active against Gram-negative bacteria were inoculated with Escherichia coli and Pseudomonas aeruginosa to give mean total survival levels of 4.4 X 10(5) c.f.u. per bar which was 70-fold higher than those reported on used soap bars [3].
  • For 9 weeks, 50 patients with moderately severe atopic dermatitis bathed daily with either an antimicrobial soap containing 1.5% triclocarban or the placebo soap [4].
 

High impact information on TCC Soap

 

Biological context of TCC Soap

  • In neighbourhoods with handwashing promotion, 300 households each were assigned to antibacterial soap containing 1.2% triclocarban and to plain soap [9].
 

Associations of TCC Soap with other chemical compounds

 

Gene context of TCC Soap

  • A method is described for quantitating the deposition of the soap germicide, 3,4,4'-trichlorocarbanilide (TCC) as the result of direct application of bar soap on human skin [11].
 

Analytical, diagnostic and therapeutic context of TCC Soap

References

  1. The effect of antibacterial soap on impetigo incidence, Karachi, Pakistan. Luby, S., Agboatwalla, M., Schnell, B.M., Hoekstra, R.M., Rahbar, M.H., Keswick, B.H. Am. J. Trop. Med. Hyg. (2002) [Pubmed]
  2. The metabolism and toxicity of halogenated carbanilides. Biliary metabolites of 3,4,4'-trichlorocarbanilide and 3-trifluoromethyl-4,4'-dichlorocarbanilide in the rat. Jeffcoat, A.R., Handy, R.W., Francis, M.T., Willis, S., Wall, M.E., Birch, C.G., Hiles, R.A. Drug Metab. Dispos. (1977) [Pubmed]
  3. Washing with contaminated bar soap is unlikely to transfer bacteria. Heinze, J.E., Yackovich, F. Epidemiol. Infect. (1988) [Pubmed]
  4. The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis. Breneman, D.L., Hanifin, J.M., Berge, C.A., Keswick, B.H., Neumann, P.B. Cutis; cutaneous medicine for the practitioner. (2000) [Pubmed]
  5. Biotransformation products of 3,4,4'-trichlorocarbanilide in rat, monkey, and man. Birch, C.G., Hiles, R.A., Eichhold, T.H., Jeffcoat, A.R., Handy, R.W., Hill, J.M., Willis, S.L., Hess, T.R., Wall, M.E. Drug Metab. Dispos. (1978) [Pubmed]
  6. The absorption, excretion, and biotransformation of 3,4,4'-trichlorocarbanilide in humans. Hiles, R.A., Birch, C.G. Drug Metab. Dispos. (1978) [Pubmed]
  7. A selected ion monitoring GC/MS assay for 3,4,4'-trichlorocarbanilide and its metabolites in biological fluids. Gruenke, L.D., Craig, J.C., Wester, R.C., Maibach, H.I., North-Root, H., Corbin, N.C. Journal of analytical toxicology. (1987) [Pubmed]
  8. Percutaneous absorption of triclocarban in rat and man. Howes, D., Black, J.G. Toxicology (1976) [Pubmed]
  9. Effect of handwashing on child health: a randomised controlled trial. Luby, S.P., Agboatwalla, M., Feikin, D.R., Painter, J., Billhimer, W., Altaf, A., Hoekstra, R.M. Lancet (2005) [Pubmed]
  10. Simultaneous determination of chlorinated bacteriostats in cosmetic and pharmaceutical products. Wang, L.H., Tso, M., Chin, C.Y. Journal of cosmetic science. (2005) [Pubmed]
  11. Deposition of 3,4,4'-trichlorocarbanilide on human skin. North-Root, H., Demetrulias, J., Wester, R., Maibach, H., Corbin, N. Toxicol. Lett. (1984) [Pubmed]
  12. Analysis of triclocarban in aquatic samples by liquid chromatography electrospray ionization mass spectrometry. Halden, R.U., Paull, D.H. Environ. Sci. Technol. (2004) [Pubmed]
  13. High-pressure liquid chromatographic studies of TCC and metabolites in experimental animals and man. Taulli, T.A., Hill, J.T., Pounds, G.W. Journal of chromatographic science. (1977) [Pubmed]
 
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