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Chemical Compound Review:

Cyzone N'-phenyl-N-propan-2-yl- benzene-1,4-diamine

Synonyms: IPPD, S-IP, Antioxidant IP, Elastozone 34, Santoflex 36, ...

Zhao, B. et al., Choudhuri, T. et al., Conacher, M. et al., Williamson, D. et al., Pellegrino, S. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Nonox ZA

Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase [1].
Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA [2].

High impact information on Nonox ZA

Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha [3].
Regulation of matrix metalloproteinase 9 expression by Epstein-Barr virus nuclear antigen 3C and the suppressor of metastasis Nm23-H1 [4].
Detection of EBV small RNAs, latent membrane protein 2, and EBV nuclear antigen 3C expression in peripheral blood suggests full latent viral gene expression in this population [5].
Epstein-Barr virus nuclear antigen 3C regulates cyclin A/p27 complexes and enhances cyclin A-dependent kinase activity [6].
Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell lines [7].

Chemical compound and disease context of Nonox ZA

Expression of alpha V integrin is modulated by Epstein-Barr virus nuclear antigen 3C and the metastasis suppressor Nm23-H1 through interaction with the GATA-1 and Sp1 transcription factors [8].

Biological context of Nonox ZA

Epstein-barr virus nuclear antigen 3C activates the latent membrane protein 1 promoter in the presence of Epstein-Barr virus nuclear antigen 2 through sequences encompassing an spi-1/Spi-B binding site [9].
Conserved cell cycle regulatory properties within the amino terminal domain of the Epstein-Barr virus nuclear antigen 3C [10].

Gene context of Nonox ZA

Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2 [11].
An antioxidant commonly present in black rubber, N-isopropyl-N'-phenyl-p-phenylenediamine (IPPD) caused very rapid oxidation and denaturation of purified hemoglobin [12].

Analytical, diagnostic and therapeutic context of Nonox ZA

A procedure has been developed for determining N-(1-methylethyl)-N'-phenyl-1,4-benzenediamine in urine by using high-performance liquid chromatography [13].

References

Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase. Knight, J.S., Sharma, N., Robertson, E.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA. Bain, M., Watson, R.J., Farrell, P.J., Allday, M.J. J. Virol. (1996) [Pubmed]
Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha. Cotter, M.A., Robertson, E.S. Mol. Cell. Biol. (2000) [Pubmed]
Regulation of matrix metalloproteinase 9 expression by Epstein-Barr virus nuclear antigen 3C and the suppressor of metastasis Nm23-H1. Kuppers, D.A., Lan, K., Knight, J.S., Robertson, E.S. J. Virol. (2005) [Pubmed]
Epstein-Barr virus can establish infection in the absence of a classical memory B-cell population. Conacher, M., Callard, R., McAulay, K., Chapel, H., Webster, D., Kumararatne, D., Chandra, A., Spickett, G., Hopwood, P.A., Crawford, D.H. J. Virol. (2005) [Pubmed]
Epstein-Barr virus nuclear antigen 3C regulates cyclin A/p27 complexes and enhances cyclin A-dependent kinase activity. Knight, J.S., Robertson, E.S. J. Virol. (2004) [Pubmed]
Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell lines. Knight, J.S., Lan, K., Subramanian, C., Robertson, E.S. J. Virol. (2003) [Pubmed]
Expression of alpha V integrin is modulated by Epstein-Barr virus nuclear antigen 3C and the metastasis suppressor Nm23-H1 through interaction with the GATA-1 and Sp1 transcription factors. Choudhuri, T., Verma, S.C., Lan, K., Robertson, E.S. Virology (2006) [Pubmed]
Epstein-barr virus nuclear antigen 3C activates the latent membrane protein 1 promoter in the presence of Epstein-Barr virus nuclear antigen 2 through sequences encompassing an spi-1/Spi-B binding site. Zhao, B., Sample, C.E. J. Virol. (2000) [Pubmed]
Conserved cell cycle regulatory properties within the amino terminal domain of the Epstein-Barr virus nuclear antigen 3C. Sharma, N., Knight, J.S., Robertson, E.S. Virology (2006) [Pubmed]
Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2. Lin, J., Johannsen, E., Robertson, E., Kieff, E. J. Virol. (2002) [Pubmed]
Oxidative hemoglobin breakdown induced by a rubber additive. Williamson, D., Winterbourn, C.C., Swallow, W.H., Missen, A.W. Hemoglobin (1981) [Pubmed]
Rapid high-performance liquid chromatographic determination of urinary N-(1-methylethyl)-N'-phenyl-1,4-benzenediamine in workers exposed to aromatic amines. Pellegrino, S., Petrarulo, M., Testa, E., Nicolotti, A. J. Chromatogr. (1992) [Pubmed]

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