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Gene Review

MTSS1  -  metastasis suppressor 1

Homo sapiens

Synonyms: KIAA0429, MIM, MIMA, MIMB, Metastasis suppressor YGL-1, ...
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Disease relevance of MTSS1


Psychiatry related information on MTSS1


High impact information on MTSS1


Chemical compound and disease context of MTSS1


Biological context of MTSS1


Anatomical context of MTSS1


Associations of MTSS1 with chemical compounds

  • Thiamine-responsive megaloblastic anaemia with diabetes and deafness (TRMA; MIM 249270) is an autosomal recessive disease thought to be due to a defect in thiamine (vitamin B1) transport [27].
  • Our studies indicate that merlin functions as a tumor and metastasis suppressor by controlling cadherin-mediated cell:cell contact [28].
  • Sitosterolemia (MIM 210250) is a rare genetic disorder caused by disruption of the normal mechanisms that regulate dietary cholesterol absorption and prevent the accumulation of noncholesterol sterols [29].
  • This study describes the discovery of a new inherited disorder of glycosylation named "CDG-Ik." CDG-Ik (congenital disorder of glycoslyation type Ik) is based on a defect of human mannosyltransferase I (MT-I [MIM 605907]), an enzyme necessary for the elongation of dolichol-linked chitobiose during N-glycan biosynthesis [30].
  • A conservative estimate of the overall prevalence of heterozygotes was 1.01% in the Akita prefecture, Japan, giving an estimated incidence of primary systemic carnitine deficiency (MIM 212140) as 1 in 40 000 births [31].

Physical interactions of MTSS1


Regulatory relationships of MTSS1


Other interactions of MTSS1


Analytical, diagnostic and therapeutic context of MTSS1

  • Importantly, PCR primers and Northern Blotting probes used in the studies of MIM in bladder cancer did not distinguish between sequences specific for MIM or MIM-B, thus the importance of either protein to bladder cancer remains unclear [20].
  • Sequence analysis revealed that this gene was identical to KIAA 0429, has a 5.3-kb transcript that mapped to 8q24 [44].
  • Macular corneal dystrophy (MCD; MIM 217800) is an autosomal recessive hereditary disease in which progressive punctate opacities in the cornea result in bilateral loss of vision, eventually necessitating corneal transplantation [45].
  • We report the identification of mutations in a non-syndromic autosomal recessive congenital ichthyosis (ARCI) in a new gene mapping within a previously identified locus on chromosome 19p12-q12, which has been defined as LI3 in the OMIM database (MIM 604777) [46].
  • To discover novel metastasis suppressor genes that are clinically relevant in common human cancers, we used isogenic human bladder cancer cell lines and used DNA microarray technology to identify genes whose expression diminishes as a function of invasive and metastatic competence [47].


  1. Differential expression analysis of MIM (MTSS1) splice variants and a functional role of MIM in prostate cancer cell biology. Loberg, R.D., Neeley, C.K., Adam-Day, L.L., Fridman, Y., St John, L.N., Nixdorf, S., Jackson, P., Kalikin, L.M., Pienta, K.J. Int. J. Oncol. (2005) [Pubmed]
  2. Suppression of Insulin Receptor Substrate 1 (IRS-1) Promotes Mammary Tumor Metastasis. Ma, Z., Gibson, S.L., Byrne, M.A., Zhang, J., White, M.F., Shaw, L.M. Mol. Cell. Biol. (2006) [Pubmed]
  3. Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia. Boerkoel, C.F., Takashima, H., John, J., Yan, J., Stankiewicz, P., Rosenbarker, L., André, J.L., Bogdanovic, R., Burguet, A., Cockfield, S., Cordeiro, I., Fründ, S., Illies, F., Joseph, M., Kaitila, I., Lama, G., Loirat, C., McLeod, D.R., Milford, D.V., Petty, E.M., Rodrigo, F., Saraiva, J.M., Schmidt, B., Smith, G.C., Spranger, J., Stein, A., Thiele, H., Tizard, J., Weksberg, R., Lupski, J.R., Stockton, D.W. Nat. Genet. (2002) [Pubmed]
  4. Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis. Ruiz-Perez, V.L., Ide, S.E., Strom, T.M., Lorenz, B., Wilson, D., Woods, K., King, L., Francomano, C., Freisinger, P., Spranger, S., Marino, B., Dallapiccola, B., Wright, M., Meitinger, T., Polymeropoulos, M.H., Goodship, J. Nat. Genet. (2000) [Pubmed]
  5. Identification of the gene that, when mutated, causes the human obesity syndrome BBS4. Mykytyn, K., Braun, T., Carmi, R., Haider, N.B., Searby, C.C., Shastri, M., Beck, G., Wright, A.F., Iannaccone, A., Elbedour, K., Riise, R., Baldi, A., Raas-Rothschild, A., Gorman, S.W., Duhl, D.M., Jacobson, S.G., Casavant, T., Stone, E.M., Sheffield, V.C. Nat. Genet. (2001) [Pubmed]
  6. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Paloneva, J., Kestilä, M., Wu, J., Salminen, A., Böhling, T., Ruotsalainen, V., Hakola, P., Bakker, A.B., Phillips, J.H., Pekkarinen, P., Lanier, L.L., Timonen, T., Peltonen, L. Nat. Genet. (2000) [Pubmed]
  7. Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11. Arcos-Burgos, M., Castellanos, F.X., Pineda, D., Lopera, F., Palacio, J.D., Palacio, L.G., Rapoport, J.L., Berg, K., Bailey-Wilson, J.E., Muenke, M. Am. J. Hum. Genet. (2004) [Pubmed]
  8. Autosomal recessive cerebellar ataxia with oculomotor apraxia (ataxia-telangiectasia-like syndrome) is linked to chromosome 9q34. Németh, A.H., Bochukova, E., Dunne, E., Huson, S.M., Elston, J., Hannan, M.A., Jackson, M., Chapman, C.J., Taylor, A.M. Am. J. Hum. Genet. (2000) [Pubmed]
  9. Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. Ramoz, N., Reichert, J.G., Smith, C.J., Silverman, J.M., Bespalova, I.N., Davis, K.L., Buxbaum, J.D. The American journal of psychiatry. (2004) [Pubmed]
  10. A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Miyamoto, Y., Mabuchi, A., Shi, D., Kubo, T., Takatori, Y., Saito, S., Fujioka, M., Sudo, A., Uchida, A., Yamamoto, S., Ozaki, K., Takigawa, M., Tanaka, T., Nakamura, Y., Jiang, Q., Ikegawa, S. Nat. Genet. (2007) [Pubmed]
  11. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Li, W., Zhang, Q., Oiso, N., Novak, E.K., Gautam, R., O'Brien, E.P., Tinsley, C.L., Blake, D.J., Spritz, R.A., Copeland, N.G., Jenkins, N.A., Amato, D., Roe, B.A., Starcevic, M., Dell'Angelica, E.C., Elliott, R.W., Mishra, V., Kingsmore, S.F., Paylor, R.E., Swank, R.T. Nat. Genet. (2003) [Pubmed]
  12. The gene encoding ganglioside-induced differentiation-associated protein 1 is mutated in axonal Charcot-Marie-Tooth type 4A disease. Cuesta, A., Pedrola, L., Sevilla, T., García-Planells, J., Chumillas, M.J., Mayordomo, F., LeGuern, E., Marín, I., Vílchez, J.J., Palau, F. Nat. Genet. (2002) [Pubmed]
  13. Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry. Olbrich, H., Häffner, K., Kispert, A., Völkel, A., Volz, A., Sasmaz, G., Reinhardt, R., Hennig, S., Lehrach, H., Konietzko, N., Zariwala, M., Noone, P.G., Knowles, M., Mitchison, H.M., Meeks, M., Chung, E.M., Hildebrandt, F., Sudbrak, R., Omran, H. Nat. Genet. (2002) [Pubmed]
  14. Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism. Ueki, Y., Tiziani, V., Santanna, C., Fukai, N., Maulik, C., Garfinkle, J., Ninomiya, C., doAmaral, C., Peters, H., Habal, M., Rhee-Morris, L., Doss, J.B., Kreiborg, S., Olsen, B.R., Reichenberger, E. Nat. Genet. (2001) [Pubmed]
  15. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Tartaglia, M., Mehler, E.L., Goldberg, R., Zampino, G., Brunner, H.G., Kremer, H., van der Burgt, I., Crosby, A.H., Ion, A., Jeffery, S., Kalidas, K., Patton, M.A., Kucherlapati, R.S., Gelb, B.D. Nat. Genet. (2001) [Pubmed]
  16. Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (bo,+AT) of rBAT. Feliubadaló, L., Font, M., Purroy, J., Rousaud, F., Estivill, X., Nunes, V., Golomb, E., Centola, M., Aksentijevich, I., Kreiss, Y., Goldman, B., Pras, M., Kastner, D.L., Pras, E., Gasparini, P., Bisceglia, L., Beccia, E., Gallucci, M., de Sanctis, L., Ponzone, A., Rizzoni, G.F., Zelante, L., Bassi, M.T., George, A.L., Manzoni, M., De Grandi, A., Riboni, M., Endsley, J.K., Ballabio, A., Borsani, G., Reig, N., Fernández, E., Estévez, R., Pineda, M., Torrents, D., Camps, M., Lloberas, J., Zorzano, A., Palacín, M. Nat. Genet. (1999) [Pubmed]
  17. A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases. Verheijen, F.W., Verbeek, E., Aula, N., Beerens, C.E., Havelaar, A.C., Joosse, M., Peltonen, L., Aula, P., Galjaard, H., van der Spek, P.J., Mancini, G.M. Nat. Genet. (1999) [Pubmed]
  18. Deletion of mitochondrial DNA in a case of early-onset diabetes mellitus, optic atrophy, and deafness (Wolfram syndrome, MIM 222300). Rötig, A., Cormier, V., Chatelain, P., Francois, R., Saudubray, J.M., Rustin, P., Munnich, A. J. Clin. Invest. (1993) [Pubmed]
  19. Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27. Matsumine, H., Saito, M., Shimoda-Matsubayashi, S., Tanaka, H., Ishikawa, A., Nakagawa-Hattori, Y., Yokochi, M., Kobayashi, T., Igarashi, S., Takano, H., Sanpei, K., Koike, R., Mori, H., Kondo, T., Mizutani, Y., Schäffer, A.A., Yamamura, Y., Nakamura, S., Kuzuhara, S., Tsuji, S., Mizuno, Y. Am. J. Hum. Genet. (1997) [Pubmed]
  20. Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines. Nixdorf, S., Grimm, M.O., Loberg, R., Marreiros, A., Russell, P.J., Pienta, K.J., Jackson, P. Cancer Lett. (2004) [Pubmed]
  21. SPTLC1 is mutated in hereditary sensory neuropathy, type 1. Bejaoui, K., Wu, C., Scheffler, M.D., Haan, G., Ashby, P., Wu, L., de Jong, P., Brown, R.H. Nat. Genet. (2001) [Pubmed]
  22. Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group. Drenth, J.P., Cuisset, L., Grateau, G., Vasseur, C., van de Velde-Visser, S.D., de Jong, J.G., Beckmann, J.S., van der Meer, J.W., Delpech, M. Nat. Genet. (1999) [Pubmed]
  23. Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. Bompard, G., Sharp, S.J., Freiss, G., Machesky, L.M. J. Cell. Sci. (2005) [Pubmed]
  24. Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism. Mattila, P.K., Pykäläinen, A., Saarikangas, J., Paavilainen, V.O., Vihinen, H., Jokitalo, E., Lappalainen, P. J. Cell Biol. (2007) [Pubmed]
  25. Ulnar-mammary syndrome with dysmorphic facies and mental retardation caused by a novel 1.28 Mb deletion encompassing the TBX3 gene. Klopocki, E., Neumann, L.M., T??nnies, H., Ropers, H.H., Mundlos, S., Ullmann, R. Eur. J. Hum. Genet. (2006) [Pubmed]
  26. The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy. Bomont, P., Cavalier, L., Blondeau, F., Ben Hamida, C., Belal, S., Tazir, M., Demir, E., Topaloglu, H., Korinthenberg, R., Tüysüz, B., Landrieu, P., Hentati, F., Koenig, M. Nat. Genet. (2000) [Pubmed]
  27. The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter. Fleming, J.C., Tartaglini, E., Steinkamp, M.P., Schorderet, D.F., Cohen, N., Neufeld, E.J. Nat. Genet. (1999) [Pubmed]
  28. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Lallemand, D., Curto, M., Saotome, I., Giovannini, M., McClatchey, A.I. Genes Dev. (2003) [Pubmed]
  29. Liver transplantation in a patient with sitosterolemia and cirrhosis. Miettinen, T.A., Klett, E.L., Gylling, H., Isoniemi, H., Patel, S.B. Gastroenterology (2006) [Pubmed]
  30. Congenital disorder of glycosylation type Ik (CDG-Ik): a defect of mannosyltransferase I. Kranz, C., Denecke, J., Lehle, L., Sohlbach, K., Jeske, S., Meinhardt, F., Rossi, R., Gudowius, S., Marquardt, T. Am. J. Hum. Genet. (2004) [Pubmed]
  31. Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency. Koizumi, A., Nozaki, J., Ohura, T., Kayo, T., Wada, Y., Nezu, J., Ohashi, R., Tamai, I., Shoji, Y., Takada, G., Kibira, S., Matsuishi, T., Tsuji, A. Hum. Mol. Genet. (1999) [Pubmed]
  32. The roles of kisspeptins and G protein-coupled receptor-54 in pubertal development. Tena-Sempere, M. Curr. Opin. Pediatr. (2006) [Pubmed]
  33. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. Fournier, H.N., Dupé-Manet, S., Bouvard, D., Lacombe, M.L., Marie, C., Block, M.R., Albiges-Rizo, C. J. Biol. Chem. (2002) [Pubmed]
  34. Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells. Salerno, M., Palmieri, D., Bouadis, A., Halverson, D., Steeg, P.S. Mol. Cell. Biol. (2005) [Pubmed]
  35. Menin, the multiple endocrine neoplasia type 1 gene product, exhibits GTP-hydrolyzing activity in the presence of the tumor metastasis suppressor nm23. Yaguchi, H., Ohkura, N., Tsukada, T., Yamaguchi, K. J. Biol. Chem. (2002) [Pubmed]
  36. Phosphoglycerate mutase-derived polypeptide inhibits glycolytic flux and induces cell growth arrest in tumor cell lines. Engel, M., Mazurek, S., Eigenbrodt, E., Welter, C. J. Biol. Chem. (2004) [Pubmed]
  37. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Li, Z., Wang, C., Jiao, X., Lu, Y., Fu, M., Quong, A.A., Dye, C., Yang, J., Dai, M., Ju, X., Zhang, X., Li, A., Burbelo, P., Stanley, E.R., Pestell, R.G. Mol. Cell. Biol. (2006) [Pubmed]
  38. The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation. Utikal, J., Gratchev, A., Muller-Molinet, I., Oerther, S., Kzhyshkowska, J., Arens, N., Grobholz, R., Kannookadan, S., Goerdt, S. Int. J. Cancer (2006) [Pubmed]
  39. The role of nm23 in transforming growth factor beta 1-mediated adherence and growth arrest. Hsu, S., Huang, F., Wang, L., Banerjee, S., Winawer, S., Friedman, E. Cell Growth Differ. (1994) [Pubmed]
  40. The p75(NTR) metastasis suppressor inhibits urokinase plasminogen activator, matrix metalloproteinase-2 and matrix metalloproteinase-9 in PC-3 prostate cancer cells. Nalbandian, A., Djakiew, D. Clin. Exp. Metastasis (2006) [Pubmed]
  41. Gene expression profile associated with response to doxorubicin-based therapy in breast cancer. Folgueira, M.A., Carraro, D.M., Brentani, H., Patrão, D.F., Barbosa, E.M., Netto, M.M., Caldeira, J.R., Katayama, M.L., Soares, F.A., Oliveira, C.T., Reis, L.F., Kaiano, J.H., Camargo, L.P., Vêncio, R.Z., Snitcovsky, I.M., Makdissi, F.B., e Silva, P.J., Góes, J.C., Brentani, M.M. Clin. Cancer Res. (2005) [Pubmed]
  42. Breast Cancer Metastasis Suppressor 1 Functions as a Corepressor by Enhancing Histone Deacetylase 1-Mediated Deacetylation of RelA/p65 and Promoting Apoptosis. Liu, Y., Smith, P.W., Jones, D.R. Mol. Cell. Biol. (2006) [Pubmed]
  43. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. Zhang, X.A., Lane, W.S., Charrin, S., Rubinstein, E., Liu, L. Cancer Res. (2003) [Pubmed]
  44. MIM, a potential metastasis suppressor gene in bladder cancer. Lee, Y.G., Macoska, J.A., Korenchuk, S., Pienta, K.J. Neoplasia (2002) [Pubmed]
  45. Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene. Akama, T.O., Nishida, K., Nakayama, J., Watanabe, H., Ozaki, K., Nakamura, T., Dota, A., Kawasaki, S., Inoue, Y., Maeda, N., Yamamoto, S., Fujiwara, T., Thonar, E.J., Shimomura, Y., Kinoshita, S., Tanigami, A., Fukuda, M.N. Nat. Genet. (2000) [Pubmed]
  46. Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3. Lefèvre, C., Bouadjar, B., Ferrand, V., Tadini, G., Mégarbané, A., Lathrop, M., Prud'homme, J.F., Fischer, J. Hum. Mol. Genet. (2006) [Pubmed]
  47. RhoGDI2 is an invasion and metastasis suppressor gene in human cancer. Gildea, J.J., Seraj, M.J., Oxford, G., Harding, M.A., Hampton, G.M., Moskaluk, C.A., Frierson, H.F., Conaway, M.R., Theodorescu, D. Cancer Res. (2002) [Pubmed]
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