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Chemical Compound Review

Maxalt     benzoic acid; N,N-dimethyl-2-[5-(1,2,4...

Synonyms: RHB-103, SureCN41226, S1607_Selleck, INT-0008, AC-734, ...
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Disease relevance of D00675

  • BACKGROUND: Rizatriptan (MK-462) is a new 5-hydroxytryptamine1D (serotonin1D; 5-HT1D) receptor agonist for the acute treatment of migraine that has improved pharmacokinetic properties compared with sumatriptan succinate [1].
  • The most common adverse events associated with MK-462 were drowsiness (20 mg 12%; 40 mg 44%; placebo 24%), dry mouth (40 mg 36%; placebo 19%), and lightheadedness/dizziness (40 mg 17%; placebo 10%) [2].

High impact information on D00675


Chemical compound and disease context of D00675


Biological context of D00675


Anatomical context of D00675


Gene context of D00675


Analytical, diagnostic and therapeutic context of D00675


  1. Rizatriptan vs sumatriptan in the acute treatment of migraine. A placebo-controlled, dose-ranging study. Dutch/US Rizatriptan Study Group. Visser, W.H., Terwindt, G.M., Reines, S.A., Jiang, K., Lines, C.R., Ferrari, M.D. Arch. Neurol. (1996) [Pubmed]
  2. Pilot study of MK-462 in migraine. Cutler, N.R., Claghorn, J., Sramek, J.J., Block, G., Panebianco, D., Cheng, H., Olah, T.V., Reines, S.A. Cephalalgia : an international journal of headache. (1996) [Pubmed]
  3. Acute treatment of migraine attacks. Ferrari, M.D., Haan, J. Curr. Opin. Neurol. (1995) [Pubmed]
  4. A double-blind, placebo-controlled evaluation of the effect of oral doses of rizatriptan 10 mg on oral contraceptive pharmacokinetics in healthy female volunteers. Shadle, C.R., Liu, G., Goldberg, M.R. Journal of clinical pharmacology. (2000) [Pubmed]
  5. Initial human experience with MK-462 (rizatriptan): a novel 5-HT1D agonist. Sciberras, D.G., Polvino, W.J., Gertz, B.J., Cheng, H., Stepanavage, M., Wittreich, J., Olah, T., Edwards, M., Mant, T. British journal of clinical pharmacology. (1997) [Pubmed]
  6. Rizatriptan: a pharmacoeconomic review of its use in the acute treatment of migraine. McCormack, P.L., Foster, R.H. PharmacoEconomics. (2005) [Pubmed]
  7. The use of stable isotope labeling and liquid chromatography/tandem mass spectrometry techniques to study the pharmacokinetics and bioavailability of the antimigraine drug, MK-0462 (rizatriptan) in dogs. Barrish, A., Olah, T.V., Gatto, G.J., Michel, K.B., Dobrinska, M.R., Gilbert, J.D. Rapid Commun. Mass Spectrom. (1996) [Pubmed]
  8. Pharmacokinetics and food interaction of MK-462 in healthy males. Cheng, H., Polvino, W.J., Sciberras, D., Yogendran, L., Cerchio, K.A., Christie, K., Olah, T.V., McLoughlin, D., James, I., Rogers, J.D. Biopharmaceutics & drug disposition. (1996) [Pubmed]
  9. Comparison of the vasoconstrictor properties of the 5-HT1D-receptor agonists rizatriptan (MK-462) and sumatriptan in human isolated coronary artery: outcome of two independent studies using different experimental protocols. Longmore, J., Hargreaves, R.J., Boulanger, C.M., Brown, M.J., Desta, B., Ferro, A., Schofield, W.N., Taylor, A.A., Hill, R.G. Funct. Neurol. (1997) [Pubmed]
  10. The effects of moclobemide on the pharmacokinetics of the 5-HT1B/1D agonist rizatriptan in healthy volunteers. Van Haarst, A.D., Van Gerven, J.M., Cohen, A.F., De Smet, M., Sterrett, A., Birk, K.L., Fisher, A.L., De Puy, M.E., Goldberg, M.R., Musson, D.G. British journal of clinical pharmacology. (1999) [Pubmed]
  11. A comparison of the contractile effects of 5-hydroxytryptamine, sumatriptan and MK-462 on human coronary artery in vitro. Ferro, A., Longmore, J., Hill, R.G., Brown, M.J. British journal of clinical pharmacology. (1995) [Pubmed]
  12. Pharmacokinetics and tolerability of intravenous rizatriptan in healthy females. Lee, Y., Ermlich, S.J., Sterrett, A.T., Goldberg, M.R., Blum, R.A., Brucker, M.J., McLoughlin, D.A., Olah, T.V., Zhao, J., Rogers, J.D. Biopharmaceutics & drug disposition. (1998) [Pubmed]
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