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MeSH Review

Food-Drug Interactions

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Disease relevance of Food-Drug Interactions


High impact information on Food-Drug Interactions


Biological context of Food-Drug Interactions


Anatomical context of Food-Drug Interactions

  • The aim of the present food interaction study was to determine the blood plasma levels of theophylline upon the administration of new Egifilin 200 and 400 mg retard tablets, either on an empty stomach or after meal, and to make comparative pharmacokinetic evaluation in 26 healthy volunteers [10].

Associations of Food-Drug Interactions with chemical compounds


Gene context of Food-Drug Interactions


Analytical, diagnostic and therapeutic context of Food-Drug Interactions

  • Furthermore, the need for frequent and demanding INR monitoring, a slow onset of action, and an elevated risk for drug-drug and food-drug interactions conspire to undermine the use of warfarin, especially in high-risk groups, such as the elderly [19].
  • METHODS: Four clinical trials covering the dose range of 25-10,000 microg/kg were carried out to describe pharmacokinetics, pharmacodynamics and tolerability of safinamide, administered in single or repeated dose regimen to steady state, including a food interaction trial [20].
  • These are Drug Therapy Screening System from Medi-span and RxTriage from First Data Bank. First Data Bank is also the most frequently cited source for the drug-food interactions and IV compatibility databases [21].


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  2. Interactions of warfarin with drugs and food. Wells, P.S., Holbrook, A.M., Crowther, N.R., Hirsh, J. Ann. Intern. Med. (1994) [Pubmed]
  3. Clinically relevant differences between the statins: implications for therapeutic selection. Chong, P.H., Seeger, J.D., Franklin, C. Am. J. Med. (2001) [Pubmed]
  4. Dietary effects on drug metabolism and transport. Harris, R.Z., Jang, G.R., Tsunoda, S. Clinical pharmacokinetics. (2003) [Pubmed]
  5. Drug interactions with irbesartan. Marino, M.R., Vachharajani, N.N. Clinical pharmacokinetics. (2001) [Pubmed]
  6. Food interaction and steady-state pharmacokinetics of itraconazole capsules in healthy male volunteers. Barone, J.A., Koh, J.G., Bierman, R.H., Colaizzi, J.L., Swanson, K.A., Gaffar, M.C., Moskovitz, B.L., Mechlinski, W., Van de Velde, V. Antimicrob. Agents Chemother. (1993) [Pubmed]
  7. Oral pharmacokinetics and food interaction of the leukotriene D4 receptor antagonist verlukast. Schwartz, J.I., Margolskee, D.J., Bjornsson, T.D., Williams, V.C., Hsieh, J.Y., Lin, C.C., Rogers, J.D. British journal of clinical pharmacology. (1993) [Pubmed]
  8. Clinical pharmacology of reversible monoamine oxidase-A inhibitors. Bieck, P.R., Antonin, K.H., Schmidt, E. Clinical neuropharmacology. (1993) [Pubmed]
  9. Pharmacokinetic properties of tramadol sustained release capsules. 2nd communication: investigation of relative bioavailability and food interaction. Raber, M., Schulz, H.U., Schürer, M., Bias-Imhoff, U., Momberger, H. Arzneimittel-Forschung. (1999) [Pubmed]
  10. Food interaction study of a new theophylline (Egifilin) 200 and 400 mg retard tablet in healthy volunteers. Urmös, I., Grézal, G., Balogh Nemes, K., Szállási, T., Drabant, S., Csörgo, M., Klebovich, I. International journal of clinical pharmacology and therapeutics. (1997) [Pubmed]
  11. Food interactions with sustained-release theophylline preparations. A review. Jonkman, J.H. Clinical pharmacokinetics. (1989) [Pubmed]
  12. Pharmacokinetics of roxatidine in healthy volunteers. Collins, J.D., Pidgen, A.W. Drugs (1988) [Pubmed]
  13. Drug-drug and drug-food interactions between tenofovir disoproxil fumarate and didanosine. Kearney, B.P., Sayre, J.R., Flaherty, J.F., Chen, S.S., Kaul, S., Cheng, A.K. Journal of clinical pharmacology. (2005) [Pubmed]
  14. Drug-food interaction potential of clarithromycin, a new macrolide antimicrobial. Chu, S., Park, Y., Locke, C., Wilson, D.S., Cavanaugh, J.C. Journal of clinical pharmacology. (1992) [Pubmed]
  15. Food-drug interactions via human cytochrome P450 3A (CYP3A). Fujita, K. Drug metabolism and drug interactions. (2004) [Pubmed]
  16. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. Bhardwaj, R.K., Glaeser, H., Becquemont, L., Klotz, U., Gupta, S.K., Fromm, M.F. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  17. Effect of daidzein on CYP1A2 activity and pharmacokinetics of theophylline in healthy volunteers. Peng, W.X., Li, H.D., Zhou, H.H. Eur. J. Clin. Pharmacol. (2003) [Pubmed]
  18. Isoniazid drug and food interactions. Self, T.H., Chrisman, C.R., Baciewicz, A.M., Bronze, M.S. Am. J. Med. Sci. (1999) [Pubmed]
  19. Oral anticoagulation: challenges in the case-management setting. Lowery, S., Haley, K., Bussey, H.I. Lippincott's case management : managing the process of patient care. (2005) [Pubmed]
  20. Pharmacokinetics and pharmacodynamics of safinamide, a neuroprotectant with antiparkinsonian and anticonvulsant activity. Marzo, A., Dal Bo, L., Monti, N.C., Crivelli, F., Ismaili, S., Caccia, C., Cattaneo, C., Fariello, R.G. Pharmacol. Res. (2004) [Pubmed]
  21. Survey of pharmacy computer vendors--sources of clinical databases. Giudici, R.A., Poirier, T.I. Hospital pharmacy. (1991) [Pubmed]
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