Disease relevance of Food-Drug Interactions

• All patients receiving orlistat for the management of obesity should be properly educated about this potential drug-food interaction [1].

High impact information on Food-Drug Interactions

• STUDY SELECTION: All articles reporting original data on drug and food interactions with warfarin [2].
• The low-density lipoprotein (LDL) cholesterol-lowering efficacy, pharmacokinetic properties, drug-food interactions, and cost can vary widely, thus influencing the selection of a particular statin as a treatment option [3].
• Food-drug interactions involving CYP1A2, CYP2E1, glucuronosyltransferases and glutathione S-transferases have also been documented, although most of these interactions are modest in magnitude and clinically relevant only for drugs that have a narrow therapeutic range [4].
• This paper reviews the drug and food interaction trials involving irbesartan that have been conducted to date [5].
• The results of the food interaction segment showed that a meal significantly enhances the amount of itraconazole absorbed [6].

Biological context of Food-Drug Interactions

• Oral pharmacokinetics and food interaction of the leukotriene D4 receptor antagonist verlukast [7].
• Moreover, we were unable to detect any clinically significant food interaction, following ingestion of a quantity of cheese containing sufficient tyramine to increase systolic blood pressure by at least 30 mm Hg [8].
• Pharmacokinetic properties of tramadol sustained release capsules. 2nd communication: investigation of relative bioavailability and food interaction [9].

Anatomical context of Food-Drug Interactions

• The aim of the present food interaction study was to determine the blood plasma levels of theophylline upon the administration of new Egifilin 200 and 400 mg retard tablets, either on an empty stomach or after meal, and to make comparative pharmacokinetic evaluation in 26 healthy volunteers [10].

Associations of Food-Drug Interactions with chemical compounds

• Food interactions with sustained-release theophylline preparations. A review [11].
• There was no evidence of any food interaction or interaction with other drugs such as antipyrine and propranolol [12].
• Drug-drug and drug-food interactions between tenofovir disoproxil fumarate and didanosine [13].
• The drug-drug and drug-food interactions between tenofovir DF and didanosine EC were evaluated in 2 pharmacokinetic studies in healthy adult subjects [13].
• Drug-food interaction potential of clarithromycin, a new macrolide antimicrobial [14].

Gene context of Food-Drug Interactions

• Food-drug interactions via human cytochrome P450 3A (CYP3A) [15].
• Most of these drug-food interactions are due to induction or inhibition of P-glycoprotein and/or CYP3A4 [16].
• CONCLUSIONS: Daidzein, a principal isoflavone in soybean, in higher doses may inhibit CYP1A2 activity in vivo, and physicians should be aware of potential drug-food interactions [17].
• According to results obtained thus far, cytochrome P450 3A4 (CYP3A4) appears to be a key enzyme in food-drug interactions [15].
• Isoniazid inhibits metabolism of selected benzodiazepines and vitamin D. Inhibition of monoamine oxidase and histaminase by isoniazid can cause significant drug-food interactions [18].

Analytical, diagnostic and therapeutic context of Food-Drug Interactions

• Furthermore, the need for frequent and demanding INR monitoring, a slow onset of action, and an elevated risk for drug-drug and food-drug interactions conspire to undermine the use of warfarin, especially in high-risk groups, such as the elderly [19].
• METHODS: Four clinical trials covering the dose range of 25-10,000 microg/kg were carried out to describe pharmacokinetics, pharmacodynamics and tolerability of safinamide, administered in single or repeated dose regimen to steady state, including a food interaction trial [20].
• These are Drug Therapy Screening System from Medi-span and RxTriage from First Data Bank. First Data Bank is also the most frequently cited source for the drug-food interactions and IV compatibility databases [21].

References