Disease relevance of DECAETHYLENE GLYCOL

• The enzyme from Escherichia coli has been crystallized at pH 5.9 in the presence of phenyl-UDP (P(1)-5'-uridyl-P(2)-phenyl diphosphate), a substrate analog, using PEG 10 000 in combination with Li(2)SO(4) and NaCl [1].
• Two test strains, Stenotrophomonas 3664 and Alcaligenes eutrophus 2050, were approximately 400 times more resistant to the nonionic surfactant polyoxyethylene 10 lauryl ether than V. fischeri and are useful for toxicity reduction evaluations of remediation processes which use surfactants for solubilization of hydrophobic pollutants [2].

High impact information on DECAETHYLENE GLYCOL

• Hybrid liposomes composed of dimyristoylphosphatidylcholine and polyoxyethylene (10) dodecyl ether were found to inhibit the growth of human promyelocytic leukemia (HL-60) cells without using any drugs [3].
• Crystals of D2-LCF were obtained from PEG 10 000 in space group P2(1)2(1)2(1), with unit-cell parameters a = 49.1, b = 104.7, c = 180.3 A [4].
• LAL activity of endotoxin is known to be sensitive to polymyxin B treatment and was found to be resistant to polyoxyethylene 10 cetyl ether (Brij56) treatment [5].
• Mixed micelles formed with cetyl pyridinium chloride (CPC), cetyl trimethylammonium bromide (CTAB), and polyoxyethylene (10) cetyl ether (Brij-56) mixed in different combinations in aqueous medium have been studied in detail by tensiometric, conductometric, calorimetric, spectrophotometric, and fluorimetric techniques [6].
• Polyoxyethylene 10 cetyl ether (Brij 56) maximally stimulated UDPGT activity for both T4 and T3 about two-fold at 0.0125% (w/v) detergent, suggesting that the UDPGTs are transmembrane proteins with the active site facing the lumen of the microsomal vesicles [7].

References