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Chemical Compound Review

Cetamium     1-hexadecylpyridine chloride

Synonyms: Dobendan, Medilave, Pyrisept, Tserigel, Aktivex, ...
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Disease relevance of CETYLPYRIDINIUM


High impact information on CETYLPYRIDINIUM


Chemical compound and disease context of CETYLPYRIDINIUM


Biological context of CETYLPYRIDINIUM

  • The fraction of dead cell number in the MTT assay or the Draize irritation score (in vitro and in vivo irritation data, respectively) was treated as a function of CPC concentration in the viable skin of LSE-high and guinea pig [13].
  • RESULTS: CPC concentration showing 50% irritation (IC50) was similar for the MTT assay (18.9%) and Draize test (12.3%), and a good relationship (r = 0.981) was observed between the fraction of dead cell number and the Draize score [13].
  • Heparin compounded in the CPC coating eluted into the blood and caused mild transient whole-body heparinization during rewarming from 20 degrees to 25 degrees C., as evidenced by prolongation of the thrombin time [14].
  • CPC decontamination should not be applied to pasteurized milk in future studies [15].
  • The obtained data on the kinetics and thermodynamics of adsorption of N-cetylpyridinium chloride onto the polyester, standard free energy, enthalpy, and entropy related to the process of adsorption are in accordance with our hypothesis on the mechanisms of adsorption [16].

Anatomical context of CETYLPYRIDINIUM


Associations of CETYLPYRIDINIUM with other chemical compounds



  • Specific RHAMM variants of 85- and 58-kDa size were shown to bind avidly to HA following CPC precipitations [27].
  • Incorporation of 35S-sulfate and 3H-glucosamine into cetyl pyridinium chloride (CPC)-precipitable material was characterized before and after chondroitinase or nitrous acid treatment by Sephadex G50 chromatography [28].
  • On the contrary, the TRN and CPC sprays showed little or no plaque inhibitory effects [29].
  • METHODS: Inhibitory effects against Streptococcus mutans, Lactobacillus casei, or Actinomyces naeslundii were examined by an agar-disc diffusion method using the Clearfil Protect Bond primer containing 5% MDPB and an acidic adhesion-promoting monomer MDP, the primer only with MDP, and the primer with 1% cetylpyridinium chloride [30].
  • Given the molecular structure of N-cetylpyridinium chloride (N-CP-Cl), which contains a pyridinium group, positively charged, it is feasible that such increse in |zeta| is due to the electrostatic attraction between the carboxyl groups of polyester, ionized at pH 8.5, and the pyridinium group of the surfactant [16].

Analytical, diagnostic and therapeutic context of CETYLPYRIDINIUM

  • When the bile salt is present, the separation mechanism changes from capillary zone electrophoresis (CZE) to a mixed micellar electrokinetic chromatography (MEKC)-CZE, with predominant MEKC interactions, which lead to an excellent resolution of all the solutes, including the C12-C18 homologues of BKC and CPC [31].
  • This experiment evaluated and compared cetylpyridinium chloride (CPC) precipitation, potassium acetate (KAc) precipitation, rapid filtration, modified dye-binding (AB) technique to molecular weight exclusion chromatography (PD-10) as techniques to quantitate chondrocyte proteoglycan metabolism [32].
  • On the other hand, the numbers of S. mutans cells in saliva and plaque in the control group increased immediately after the CPC treatment and surpassed the baseline level 42 and 28 days, respectively, after the CPC treatment [33].
  • These findings suggest that the CPC/phenolic rinse would seem worthy of further evaluation for adjunctive benefits to oral hygiene [34].
  • The results support the previous findings that a CPC/essential oil rinse could be a useful adjunct to oral hygiene when used prior to normal toothbrushing [35].


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  3. Cetyl-pyridinium chloride is useful for isolation of Mycobacterium tuberculosis from sputa subjected to long-term storage. Pardini, M., Varaine, F., Iona, E., Arzumanian, E., Checchi, F., Oggioni, M.R., Orefici, G., Fattorini, L. J. Clin. Microbiol. (2005) [Pubmed]
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  5. Spraying chicken skin with selected chemicals to reduce attached Salmonella typhimurium. Xiong, H., Li, Y., Slavik, M.F., Walker, J.T. J. Food Prot. (1998) [Pubmed]
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  12. Detection of Mycobacterium avium subspecies paratuberculosis in Swiss dairy cattle by culture and serology. Glanemann, B., Hoelzle, L.E., Bögli-Stuber, K., Jemmi, T., Wittenbrink, M.M. Schweiz. Arch. Tierheilkd. (2004) [Pubmed]
  13. Utility of MTT assay in three-dimensional cultured human skin model as an alternative for draize skin irritation test: approach using diffusion law of irritant in skin and toxicokinetics-toxicodynamics correlation. Watanabe, T., Hasegawa, T., Takahashi, H., Ishibashi, T., Itagaki, H., Sugibayashi, K. Pharm. Res. (2002) [Pubmed]
  14. Use of athrombogenic tubing for perfusion rewarming following surface-induced deep hypothermia. Mohri, H., Ishitoya, T., Hessel, E.A., Schmer, G., Dillard, D.H., Merendino, K.A. J. Thorac. Cardiovasc. Surg. (1979) [Pubmed]
  15. Effect of chemical decontamination and refrigerated storage on the isolation of Mycobacterium avium subsp. paratuberculosis from heat-treated milk. Grant, I.R., Rowe, M.T. Lett. Appl. Microbiol. (2004) [Pubmed]
  16. Electrokinetic and thermodynamic analysis of the adsorption process of N-cetylpyridinium chloride on polyester fabric. Espinosa-Jiménez, M., Padilla-Weigand, R., Ortega, A.O., Perea-Carpio, R. Journal of colloid and interface science. (2002) [Pubmed]
  17. Analysis of glycosaminoglycans of flow sorted cells: incorporation of [35S]sulfate and [3H]glucosamine into glycosaminoglycans of B16-F10 cells during the cell cycle. Blair, O.C., Burger, D.E., Sartorelli, A.C. Cytometry. (1982) [Pubmed]
  18. Development of a filter assay for measuring homogalacturonan: alpha-(1,4)-Galacturonosyltransferase activity. Sterling, J.D., Lemons, J.A., Forkner, I.F., Mohnen, D. Anal. Biochem. (2005) [Pubmed]
  19. The effect of cetylpyridinium chloride (CPC) on the cell surface hydrophobicity and adherence of Candida albicans to human buccal epithelial cells in vitro. Jones, D.S., Schep, L.J., Shepherd, M.G. Pharm. Res. (1995) [Pubmed]
  20. Anisotropic action of cetyl pyridinium chloride on rat heart mitochondria. Chávez, E., Bravo, C. Arch. Biochem. Biophys. (1982) [Pubmed]
  21. Histochemical evaluation of glycosaminoglycan deposition in the skin. Kupchella, C.E., Matsuoka, L.Y., Bryan, B., Wortsman, J., Dietrich, J.G. J. Histochem. Cytochem. (1984) [Pubmed]
  22. Techniques to preserve soluble surface components in birch pollen wall: a scanning and transmission electron microscopic study. Grote, M. J. Histochem. Cytochem. (1989) [Pubmed]
  23. Suramin-induced mucopolysaccharidosis in rat incisor. Gritli, A., Septier, D., Goldberg, M. Cell Tissue Res. (1993) [Pubmed]
  24. Effects of pH and cationic and nonionic surfactants on the adsorption of pharmaceuticals to a natural aquifer material. Hari, A.C., Paruchuri, R.A., Sabatini, D.A., Kibbey, T.C. Environ. Sci. Technol. (2005) [Pubmed]
  25. Gene expression by human articular chondrocytes cultured in alginate beads. Chubinskaya, S., Huch, K., Schulze, M., Otten, L., Aydelotte, M.B., Cole, A.A. J. Histochem. Cytochem. (2001) [Pubmed]
  26. Analysis of the Rhizobium meliloti exoH/exoK/exoL fragment: ExoK shows homology to excreted endo-beta-1,3-1,4-glucanases and ExoH resembles membrane proteins. Becker, A., Kleickmann, A., Arnold, W., Pühler, A. Mol. Gen. Genet. (1993) [Pubmed]
  27. Hyaluronate receptors mediating glioma cell migration and proliferation. Akiyama, Y., Jung, S., Salhia, B., Lee, S., Hubbard, S., Taylor, M., Mainprize, T., Akaishi, K., van Furth, W., Rutka, J.T. J. Neurooncol. (2001) [Pubmed]
  28. Incorporation of 35S-sulfate and 3H-glucosamine into heparan and chondroitin sulfates during the cell cycle of B16-F10 cells. Blair, O.C., Sartorelli, A.C. Cytometry. (1984) [Pubmed]
  29. The effects of antimicrobial sprays and mouthrinses on supragingival plaque regrowth: a comparative study. Pizzo, G., Guiglia, R., Imburgia, M., Pizzo, I., D'Angelo, M., Giuliana, G. J. Periodontol. (2006) [Pubmed]
  30. In vitro antibacterial effects of the dentin primer of Clearfil Protect Bond. Imazato, S., Kuramoto, A., Takahashi, Y., Ebisu, S., Peters, M.C. Dental materials : official publication of the Academy of Dental Materials. (2006) [Pubmed]
  31. Determination of cationic surfactants by capillary zone electrophoresis and micellar electrokinetic chromatography with deoxycholate micelles in the presence of large organic solvent concentrations. Herrero-Martínez, J.M., Simó-Alfonso, E.F., Mongay-Fernández, C., Ramis-Ramos, G. Journal of chromatography. A. (2000) [Pubmed]
  32. The assessment of chondrocyte proteoglycan metabolism using molecular sieve column chromatography as compared to three commonly utilized techniques. Frisbie, D.D., Kawcak, C.E., Trotter, G.W., McIlwraith, C.W. Osteoarthr. Cartil. (1998) [Pubmed]
  33. Passive immunization with milk produced from an immunized cow prevents oral recolonization by Streptococcus mutans. Shimazaki, Y., Mitoma, M., Oho, T., Nakano, Y., Yamashita, Y., Okano, K., Nakano, Y., Fukuyama, M., Fujihara, N., Nada, Y., Koga, T. Clin. Diagn. Lab. Immunol. (2001) [Pubmed]
  34. Efficacy of mouthrinses in inhibiting the development of supragingival plaque over a 4-day period of no oral hygiene. Moran, J., Addy, M., Kohut, B., Hovliaras, C.A., Newcombe, R.G. J. Periodontol. (1994) [Pubmed]
  35. A study of a pre-brushing mouthrinse as an adjunct to oral hygiene. Hunter, L., Addy, M., Moran, J., Kohut, B., Hovliaras, C.A., Newcombe, R.G. J. Periodontol. (1994) [Pubmed]
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