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Chemical Compound Review

NONANAL     nonanal

Synonyms: Nonaldehyde, Nonanaldehyde, Nonylaldehyde, n-Nonanal, n-Nonaldehyde, ...
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Disease relevance of pelargonaldehyde


High impact information on pelargonaldehyde

  • The enzyme specifically uses NADPH to reduce a variety of short-chain aldehydes, including nonanal and 4-hydroxy-2-nonenal [3].
  • If the atmosphere is changed from CO/H(2) to H(2) the catalyst system is switched to the hydrogenation mode (Y), which shows a clean and complete hydrogenation of 1-octene and 1-nonanal within 24 h [4].
  • Aldehydes (malondialdehyde, hexanal, heptanal, and nonanal) were measured by liquid chromatography-tandem mass spectrometry in all samples and overlapping results were obtained by different sampling procedures [1].
  • Gas chromatography-mass spectral analysis also showed the accumulation of nonanal in sealed reaction vials, accounting for the other product of the acyl chain cleavage reaction [5].
  • Three of them, nonanal, decanal, and hexenyl acetate promoted the development of haustoria on artificial membranes [6].

Chemical compound and disease context of pelargonaldehyde


Biological context of pelargonaldehyde


Anatomical context of pelargonaldehyde


Associations of pelargonaldehyde with other chemical compounds


Gene context of pelargonaldehyde

  • There was a bell-shaped dose-response curve to the enhancing effects of HNE, depending on the incubation time being recorded after only short periods (< or = 5 min) of the exposure of the cells to HNE; this was not shown by structurally-related aldehydes, such as 2-nonenal and nonanal [18].

Analytical, diagnostic and therapeutic context of pelargonaldehyde

  • Five compounds identified by gas chromatography in the headspace of O. stricta elicited responses in olfactory receptor cells of C. cactorum, nonanal being the most active compound and therefore a candidate attractant of C. cactorum [19].


  1. Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease. Corradi, M., Rubinstein, I., Andreoli, R., Manini, P., Caglieri, A., Poli, D., Alinovi, R., Mutti, A. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  2. The mixture of aldehydes and hydrogen peroxide produced in the ozonation of dioleoyl phosphatidylcholine causes hemolysis of human red blood cells. Pryor, W.A., Miki, M., Das, B., Church, D.F. Chem. Biol. Interact. (1991) [Pubmed]
  3. Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins. Kasus-Jacobi, A., Ou, J., Bashmakov, Y.K., Shelton, J.M., Richardson, J.A., Goldstein, J.L., Brown, M.S. J. Biol. Chem. (2003) [Pubmed]
  4. A silica-supported, switchable, and recyclable hydroformylation-hydrogenation catalyst. Sandee, A.J., Reek, J.N., Kamer, P.C., van Leeuwen, P.W. J. Am. Chem. Soc. (2001) [Pubmed]
  5. Chain cleavage and sulfoxidation of thiastearoyl-ACP upon reaction with stearoyl-ACP desaturase. White, R.D., Fox, B.G. Biochemistry (2003) [Pubmed]
  6. Volatiles modulate the development of plant pathogenic rust fungi. Mendgen, K., Wirsel, S.G., Jux, A., Hoffmann, J., Boland, W. Planta (2006) [Pubmed]
  7. Monoclonal antibodies for detection of 4-hydroxynonenal modified proteins. Waeg, G., Dimsity, G., Esterbauer, H. Free Radic. Res. (1996) [Pubmed]
  8. Simultaneous determination of multiple aldehydes in biological tissues and fluids using gas chromatography/stable isotope dilution mass spectrometry. Bruenner, B.A., Jones, A.D., German, J.B. Anal. Biochem. (1996) [Pubmed]
  9. Preparation of useful synthetic intermediates of Taxol analogs, cyclooctenone derivatives. Yamada, K., Tozawa, T., Saitoh, K., Mukaiyama, T. Chem. Pharm. Bull. (1997) [Pubmed]
  10. Effect of crop development on biogenic emissions from plant populations grown in closed plant growth chambers. Batten, J.H., Stutte, G.W., Wheeler, R.M. Phytochemistry (1995) [Pubmed]
  11. Possible mutagens derived from lipids and lipid precursors. Esterbauer, H., Eckl, P., Ortner, A. Mutat. Res. (1990) [Pubmed]
  12. Effect of 4-hydroxy-2,3-trans-nonenal and related aldehydes on phospholipase C activity of rat neutrophils. Rossi, M.A., Fidale, F., Di Mauro, C., Esterbauer, H., Dianzani, M.U. International journal of tissue reactions. (1993) [Pubmed]
  13. Glial fibrillary acidic protein in the optic nerve of the developing albino rat: an immunoperoxidase study of paraffin-embedded tissue. Dixon, R.G., Eng, L.F. J. Comp. Neurol. (1981) [Pubmed]
  14. Identification of heptanal and nonanal in bronchoalveolar lavage from rats exposed to low levels of ozone. Cueto, R., Squadrito, G.L., Bermudez, E., Pryor, W.A. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  15. Olfactory sensitivity for aliphatic aldehydes in CD-1 mice. Laska, M., Joshi, D., Shepherd, G.M. Behav. Brain Res. (2006) [Pubmed]
  16. Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation. Corradi, M., Pignatti, P., Manini, P., Andreoli, R., Goldoni, M., Poppa, M., Moscato, G., Balbi, B., Mutti, A. Eur. Respir. J. (2004) [Pubmed]
  17. Electrophysiological Responses of the Lepidopterous Stemborers Chilo partellus and Busseola fusca to Volatiles from Wild and Cultivated Host Plants. Birkett, M.A., Chamberlain, K., Khan, Z.R., Pickett, J.A., Toshova, T., Wadhams, L.J., Woodcock, C.M. J. Chem. Ecol. (2006) [Pubmed]
  18. Effect of 4-hydroxynonenal on superoxide anion production from primed human neutrophils. Dianzani, C., Parrini, M., Ferrara, C., Fantozzi, R. Cell Biochem. Funct. (1996) [Pubmed]
  19. Volatile organic compounds as signals in a plant-herbivore system: electrophysiological responses in olfactory sensilla of the moth Cactoblastis cactorum. Pophof, B., Stange, G., Abrell, L. Chem. Senses (2005) [Pubmed]
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