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Gene Review

Hspb1  -  heat shock protein 1

Mus musculus

Synonyms: 27kDa, Growth-related 25 kDa protein, HSP 25, HSP 27, Heat shock 25 kDa protein, ...
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Disease relevance of Hspb1

  • HSP-25 expression is increased in the proximal tubule cells in the outer stripe of the outer medulla postobstruction, prior to, and 24 h after ischemia [1].
  • In several tissues the amount of hsp25 exceeds that accumulating in NIH 3T3 fibroblasts in response to heat stress. hsp25, like alpha B crystallin, exists in a highly aggregated form in the eye lens [2].
  • Native phosphorylated mouse small heat shock protein hsp25 from Ehrlich ascites tumor cells was isolated and the in vivo phosphorylation sites of the protein were determined [3].
  • This study was conducted to assess the expression pattern of hsp27 in a panel of different ichthyoses [4].
  • Hsp27 expression was reduced in bullous ichthyosiform erythroderma and annular epidermolytic ichthyosis, and absent in X-linked recessive ichthyosis (1/3 patients) and congenital hemidysplasia with ichthyosiform nevus and limb defects syndrome (1/1) [4].

Psychiatry related information on Hspb1

  • Our results indicate that TNF-alpha induces in cardiomyocytes transiently gene expression for cytoprotective molecules like HSP-27, HSP-70 and ubiquitin, suggesting these stress proteins to participate in subsequent defense mechanisms, for example in postischemic myocardial recovery [5].

High impact information on Hspb1


Chemical compound and disease context of Hspb1


Biological context of Hspb1


Anatomical context of Hspb1


Associations of Hspb1 with chemical compounds


Physical interactions of Hspb1


Enzymatic interactions of Hspb1


Regulatory relationships of Hspb1


Other interactions of Hspb1

  • From the above results, we suggest for the first time that reduced oxidative damage by HSP25 was due to MnSOD-mediated downregulation of ERK1/2 [21].
  • p38 MAPK/HSP25 signaling mediates cadmium-induced contraction of mesangial cells and renal glomeruli [22].
  • Increased expression of Tnf and Il1b resulting from Hspb1 overexpression was detected by RT-PCR [16].
  • The inducible Hspa transfectant showed a more pronounced adaptive response than the Hspb1 transfectant [15].
  • To further elucidate the exact relationship between induction of SOD2 and Nfkb activation, a dominant negative I-kBalpha (now known as Nfkb1a) construct was transfected into Hspb1-overexpressing cells [16].

Analytical, diagnostic and therapeutic context of Hspb1


  1. Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation, and inflammation by remote transient ureteral obstruction. Park, K.M., Kramers, C., Vayssier-Taussat, M., Chen, A., Bonventre, J.V. J. Biol. Chem. (2002) [Pubmed]
  2. Expression of the murine small heat shock proteins hsp 25 and alpha B crystallin in the absence of stress. Klemenz, R., Andres, A.C., Fröhli, E., Schäfer, R., Aoyama, A. J. Cell Biol. (1993) [Pubmed]
  3. Identification of the phosphorylation sites of the murine small heat shock protein hsp25. Gaestel, M., Schröder, W., Benndorf, R., Lippmann, C., Buchner, K., Hucho, F., Erdmann, V.A., Bielka, H. J. Biol. Chem. (1991) [Pubmed]
  4. The expression of the 27-kd heat shock protein in keratinization disorders: an immunohistological study. Jonak, C., Metze, D., Traupe, H., Happle, R., König, A., Trautinger, F. Hum. Pathol. (2005) [Pubmed]
  5. Cytoprotective mechanisms in cultured cardiomyocytes. Sharma, H.S., Stahl, J., Weisensee, D., Löw-Friedrich, I. Mol. Cell. Biochem. (1996) [Pubmed]
  6. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Srivastava, P. Annu. Rev. Immunol. (2002) [Pubmed]
  7. Heat shock proteins, first major products of zygotic gene activity in mouse embryo. Bensaude, O., Babinet, C., Morange, M., Jacob, F. Nature (1983) [Pubmed]
  8. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. Nylandsted, J., Gyrd-Hansen, M., Danielewicz, A., Fehrenbacher, N., Lademann, U., Høyer-Hansen, M., Weber, E., Multhoff, G., Rohde, M., Jäättelä, M. J. Exp. Med. (2004) [Pubmed]
  9. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. Blachere, N.E., Li, Z., Chandawarkar, R.Y., Suto, R., Jaikaria, N.S., Basu, S., Udono, H., Srivastava, P.K. J. Exp. Med. (1997) [Pubmed]
  10. Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection. Jäättelä, M., Wissing, D. J. Exp. Med. (1993) [Pubmed]
  11. Hsp25 and Hsp70 in rodent tumors treated with doxorubicin and lovastatin. Ciocca, D.R., Rozados, V.R., Cuello Carrión, F.D., Gervasoni, S.I., Matar, P., Scharovsky, O.G. Cell Stress Chaperones (2003) [Pubmed]
  12. Stimulation of the stress-induced expression of stress proteins by curcumin in cultured cells and in rat tissues in vivo. Kato, K., Ito, H., Kamei, K., Iwamoto, I. Cell Stress Chaperones (1998) [Pubmed]
  13. Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis. Kubisch, C., Dimagno, M.J., Tietz, A.B., Welsh, M.J., Ernst, S.A., Brandt-Nedelev, B., Diebold, J., Wagner, A.C., Göke, B., Williams, J.A., Schäfer, C. Gastroenterology (2004) [Pubmed]
  14. Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer. Rocchi, P., So, A., Kojima, S., Signaevsky, M., Beraldi, E., Fazli, L., Hurtado-Coll, A., Yamanaka, K., Gleave, M. Cancer Res. (2004) [Pubmed]
  15. Induction of adaptive response by low-dose radiation in RIF cells transfected with Hspb1 (Hsp25) or inducible Hspa (Hsp70). Lee, Y.J., Park, G.H., Cho, H.N., Cho, C.K., Park, Y.M., Lee, S.J., Lee, Y.S. Radiat. Res. (2002) [Pubmed]
  16. Heat-shock protein 25 (Hspb1) regulates manganese superoxide dismutase through activation of Nfkb (NF-kappaB). Yi, M.J., Park, S.H., Cho, H.N., Yong Chung, H., Kim, J.I., Cho, C.K., Lee, S.J., Lee, Y.S. Radiat. Res. (2002) [Pubmed]
  17. Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress. Ropeleski, M.J., Tang, J., Walsh-Reitz, M.M., Musch, M.W., Chang, E.B. Gastroenterology (2003) [Pubmed]
  18. Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. Yan, L.J., Christians, E.S., Liu, L., Xiao, X., Sohal, R.S., Benjamin, I.J. EMBO J. (2002) [Pubmed]
  19. p38MAPK inhibition prevents disease in pemphigus vulgaris mice. Berkowitz, P., Hu, P., Warren, S., Liu, Z., Diaz, L.A., Rubenstein, D.S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  20. Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. Strey, C.W., Spellman, D., Stieber, A., Gonatas, J.O., Wang, X., Lambris, J.D., Gonatas, N.K. Am. J. Pathol. (2004) [Pubmed]
  21. HSP25 overexpression attenuates oxidative stress-induced apoptosis: roles of ERK1/2 signaling and manganese superoxide dismutase. Lee, Y.J., Cho, H.N., Jeoung, D.I., Soh, J.W., Cho, C.K., Bae, S., Chung, H.Y., Lee, S.J., Lee, Y.S. Free Radic. Biol. Med. (2004) [Pubmed]
  22. p38 MAPK/HSP25 signaling mediates cadmium-induced contraction of mesangial cells and renal glomeruli. Hirano, S., Sun, X., DeGuzman, C.A., Ransom, R.F., McLeish, K.R., Smoyer, W.E., Shelden, E.A., Welsh, M.J., Benndorf, R. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  23. MAPK-activated Protein Kinase-2 (MK2)-mediated Formation and Phosphorylation-regulated Dissociation of the Signal Complex Consisting of p38, MK2, Akt, and Hsp27. Zheng, C., Lin, Z., Zhao, Z.J., Yang, Y., Niu, H., Shen, X. J. Biol. Chem. (2006) [Pubmed]
  24. Heat shock protein 25 or inducible heat shock protein 70 activates heat shock factor 1: dephosphorylation on serine 307 through inhibition of ERK1/2 phosphorylation. Seo, H.R., Chung, D.Y., Lee, Y.J., Lee, D.H., Kim, J.I., Bae, S., Chung, H.Y., Lee, S.J., Jeoung, D., Lee, Y.S. J. Biol. Chem. (2006) [Pubmed]
  25. HSP25 inhibits protein kinase C delta-mediated cell death through direct interaction. Lee, Y.J., Lee, D.H., Cho, C.K., Bae, S., Jhon, G.J., Lee, S.J., Soh, J.W., Lee, Y.S. J. Biol. Chem. (2005) [Pubmed]
  26. Characterization of native interaction of hsp110 with hsp25 and hsc70. Wang, X.Y., Chen, X., Oh, H.J., Repasky, E., Kazim, L., Subjeck, J. FEBS Lett. (2000) [Pubmed]
  27. Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic nerve injury. Murashov, A.K., Ul Haq, I., Hill, C., Park, E., Smith, M., Wang, X., Wang, X., Goldberg, D.J., Wolgemuth, D.J. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  28. Heat shock-induced dendritic cell maturation is coupled by transient aggregation of ubiquitinated proteins independently of heat shock factor 1 or inducible heat shock protein 70. DeFillipo, A.M., Dai, J., Li, Z. Mol. Immunol. (2004) [Pubmed]
  29. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Gurbuxani, S., Schmitt, E., Cande, C., Parcellier, A., Hammann, A., Daugas, E., Kouranti, I., Spahr, C., Pance, A., Kroemer, G., Garrido, C. Oncogene (2003) [Pubmed]
  30. Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination. Shi, Y., Kotlyarov, A., Laabeta, K., Gruber, A.D., Butt, E., Marcus, K., Meyer, H.E., Friedrich, A., Volk, H.D., Gaestel, M. Mol. Cell. Biol. (2003) [Pubmed]
  31. Hsp25 regulates the expression of p21(Waf1/Cip1/Sdi1) through multiple mechanisms. Park, S.H., Lee, Y.S., Osawa, Y., Hachiya, M., Akashi, M. J. Biochem. (2002) [Pubmed]
  32. Phosphatidylinositol 3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts. Takai, S., Tokuda, H., Matsushima-Nishiwaki, R., Hanai, Y., Kato, K., Kozawa, O. J. Cell. Biochem. (2006) [Pubmed]
  33. Involvement of stress-activated protein kinase/c-Jun N-terminal kinase in endothelin-1-induced heat shock protein 27 in osteoblasts. Tokuda, H., Niwa, M., Ito, H., Oiso, Y., Kato, K., Kozawa, O. Eur. J. Endocrinol. (2003) [Pubmed]
  34. Heat shock and 5-azacytidine inhibit nitric oxide synthesis and tumor necrosis factor-alpha secretion in activated macrophages. Kim, H.D., Kang, H.S., Rimbach, G., Park, Y.C. Antioxid. Redox Signal. (1999) [Pubmed]
  35. Expression pattern of HSP25 in mouse preimplantation embryo: heat shock responses during oocyte maturation. Kim, M., Geum, D., Khang, I., Park, Y.M., Kang, B.M., Lee, K.A., Kim, K. Mol. Reprod. Dev. (2002) [Pubmed]
  36. Heat shock transcription factor HSF1 is required for survival of sensory hair cells against acoustic overexposure. Sugahara, K., Inouye, S., Izu, H., Katoh, Y., Katsuki, K., Takemoto, T., Shimogori, H., Yamashita, H., Nakai, A. Hear. Res. (2003) [Pubmed]
  37. Differential estrogenic regulation of small M(r) heat shock protein expression in osteoblasts. Cooper, L.F., Uoshima, K. J. Biol. Chem. (1994) [Pubmed]
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