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Chemical Compound Review

SureCN850802     5-(1-carboxyethenoxy)-4- hydroxy-3...

Synonyms: AG-J-04701, ACMC-20lq98, AC1Q5QFU, CTK1A2651, AR-1G6467, ...
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Disease relevance of 5-Epsp


High impact information on 5-Epsp


Biological context of 5-Epsp

  • Substrate trapping experiments in the forward and reverse reactions established the kinetically preferred order of binding and release of substrates and products and showed that shikimate 3-phosphate (S3P) and 5-enolpyruvoylshikimate 3-phosphate (EPSP) dissociate at rates greater than turnover in each direction [8].

Associations of 5-Epsp with other chemical compounds


  1. Photo-oxidation of 5-enolpyruvoylshikimate-3-phosphate synthase from Escherichia coli: evidence for a reactive imidazole group (His385) at the herbicide glyphosate-binding site. Huynh, Q.K. Biochem. J. (1993) [Pubmed]
  2. The feeding value of soybeans fed to rats, chickens, catfish and dairy cattle is not altered by genetic incorporation of glyphosate tolerance. Hammond, B.G., Vicini, J.L., Hartnell, G.F., Naylor, M.W., Knight, C.D., Robinson, E.H., Fuchs, R.L., Padgette, S.R. J. Nutr. (1996) [Pubmed]
  3. Toxicity of 40 herbicides to the green alga Chlorella vulgaris. Ma, J., Xu, L., Wang, S., Zheng, R., Jin, S., Huang, S., Huang, Y. Ecotoxicol. Environ. Saf. (2002) [Pubmed]
  4. Background-minimized cassette mutagenesis by PCR using cassette-specific selection markers: a useful general approach for studying structure-function relationships of multisubstrate enzymes. Majumder, K., Fattah, F.A., Selvapandiyan, A., Bhatnagar, R.K. PCR Methods Appl. (1995) [Pubmed]
  5. "Kinetic competence" of the 5-enolpyruvoylshikimate-3-phosphate synthase tetrahedral intermediate. Anderson, K.S., Johnson, K.A. J. Biol. Chem. (1990) [Pubmed]
  6. Site-directed mutagenesis of putative active site residues of 5-enolpyruvylshikimate-3-phosphate synthase. Shuttleworth, W.A., Pohl, M.E., Helms, G.L., Jakeman, D.L., Evans, J.N. Biochemistry (1999) [Pubmed]
  7. Steady-state kinetic evaluation of the reverse reaction for Escherichia coli 5-enolpyruvoylshikimate-3-phosphate synthase. Gruys, K.J., Marzabadi, M.R., Pansegrau, P.D., Sikorski, J.A. Arch. Biochem. Biophys. (1993) [Pubmed]
  8. A tetrahedral intermediate in the EPSP synthase reaction observed by rapid quench kinetics. Anderson, K.S., Sikorski, J.A., Johnson, K.A. Biochemistry (1988) [Pubmed]
  9. How the mutation glycine96 to alanine confers glyphosate insensitivity to 5-enolpyruvyl shikimate-3-phosphate synthase from Escherichia coli. Eschenburg, S., Healy, M.L., Priestman, M.A., Lushington, G.H., Schönbrunn, E. Planta (2002) [Pubmed]
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