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Chemical Compound Review

Roundup     2- (phosphonomethylamino)ethanoic acid

Synonyms: Silglif, Pondmaster, gliphosate, glyphosate, Glyphosphate, ...
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Disease relevance of Roundup


Psychiatry related information on Roundup

  • It was found that increases in heating temperature and heating time were unfavorable for the derivatization of glyphosate or glufosinate, whereas high temperature and extended reaction time remarkably facilitated that of AMPA and 3-MPPA except at 90 degrees C for an extended reaction time (120 min) [6].

High impact information on Roundup


Chemical compound and disease context of Roundup


Biological context of Roundup


Anatomical context of Roundup

  • Transcription of this gene is initiated at multiple sites in petunia leaves and in a glyphosate-tolerant petunia cell line overproducing EPSP synthase mRNA [15].
  • Glyphosate-damaged anthers exhibited a change in the deposition of the secondary cell wall thickenings (SWT) in the endothecium cells, from the normal longitudinal orientation to a transverse orientation, and hindered septum disintegration [16].
  • Plastid-expressed EPSPS could provide very high levels of glyphosate resistance, although levels of resistance in vegetative and reproductive tissues differed depending on EPSPS accumulation levels, and correlated to the plastid abundance in these tissues [17].
  • Glyphosate-induced anther indehiscence in cotton is partially temperature dependent and involves cytoskeleton and secondary wall modifications and auxin accumulation [16].
  • Our data demonstrate that glyphosate inhibits anther dehiscence by inducing changes in the microtubule and cell wall organization in the endothecium cells, which are mediated by auxin [16].

Associations of Roundup with other chemical compounds


Gene context of Roundup


Analytical, diagnostic and therapeutic context of Roundup

  • Selective overproduction of 5-enol-pyruvylshikimic acid 3-phosphate synthase in a plant cell culture which tolerates high doses of the herbicide glyphosate [26].
  • Analyses by high-performance liquid chromatography and liquid scintillation spectrometry of the phloem sap collected from the castor bean system, used as a systemy test, indicate decreasing capacities of 2,4D, 2,4D-Lys, and glyphosate, respectively, to move from the epidermis cell wall to the sieve element [27].
  • Thus, L'ELISA recognized the derivatized glyphosate more effectively (detection limit of 0.1 microg/L) and with increased sensitivity (10-100 times) over conventional ELISA and showed the potential for other applications [28].
  • The correlation of L'ELISA and HPLC/MS for 66 surface water and groundwater samples was 0.97 with a slope of 1.28, with many detections of glyphosate and its degradate in surface water but not in groundwater [28].
  • Capillary electrophoresis combined with mass spectrometry (CE-MS) was used for the rapid determination of the negatively charged herbicide, Glyphosate, in a selective dried granule (DG) formulation [29].


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  15. Structure, expression, and evolution of the 5-enolpyruvylshikimate-3-phosphate synthase genes of petunia and tomato. Gasser, C.S., Winter, J.A., Hironaka, C.M., Shah, D.M. J. Biol. Chem. (1988) [Pubmed]
  16. Glyphosate-induced anther indehiscence in cotton is partially temperature dependent and involves cytoskeleton and secondary wall modifications and auxin accumulation. Yasuor, H., Abu-Abied, M., Belausov, E., Madmony, A., Sadot, E., Riov, J., Rubin, B. Plant Physiol. (2006) [Pubmed]
  17. Plastid-expressed 5-enolpyruvylshikimate-3-phosphate synthase genes provide high level glyphosate tolerance in tobacco. Ye, G.N., Hajdukiewicz, P.T., Broyles, D., Rodriguez, D., Xu, C.W., Nehra, N., Staub, J.M. Plant J. (2001) [Pubmed]
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  20. Pesticide Roundup provokes cell division dysfunction at the level of CDK1/cyclin B activation. Marc, J., Mulner-Lorillon, O., Boulben, S., Hureau, D., Durand, G., Bellé, R. Chem. Res. Toxicol. (2002) [Pubmed]
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  27. Carrier-mediated uptake and phloem systemy of a 350-Dalton chlorinated xenobiotic with an alpha-amino acid function. Delétage-Grandon, C., Chollet, J.F., Faucher, M., Rocher, F., Komor, E., Bonnemain, J.L. Plant Physiol. (2001) [Pubmed]
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