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Chemical Compound Review:

Amoil dipentyl benzene-1,2-dicarboxylate

Synonyms: DPNP, Amyl phthalate, SureCN57859, HSDB 302, NSC-4720, ...

Lu, K.Y. et al., Foster, P.M. et al., Lindström, P. et al., Creasy, D.M. et al., Ahn, J.Y. et al., et al.

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Disease relevance of Dipentyl phthalate

Prepubertal rats treated orally with di-n-pentyl phthalate at 2.2 g/kg body weight were killed at 1, 3, 6 and 24 hr following a single dose, and after 2, 3 and 4 days of repeated daily dosing [1].
Accelerated degradation of dipentyl phthalate by Fusarium oxysporum f. sp. pisi cutinase and toxicity evaluation of its degradation products using bioluminescent bacteria [2].

High impact information on Dipentyl phthalate

Changes in ultrastructure and cytochemical localization of zinc in rat testis following the administration of di-n-pentyl phthalate [3].
For inhibition of human nAChR, the strongest to weakest potencies were observed as di-n-pentyl phthalate (DPP) --> butyl benzyl phthalate (BBP) --> di-n-butyl phthalate (DBP) --> dicyclohexyl phthalate (DCHP) --> di-n-hexyl phthalate (DHP) --> di-(2-ethyl hexyl) phthalate (DEHP) --> di-n-propyl phthalate (DPrP) --> diethyl phthalate (DEP) [4].
Treatment of young male rats with dipentyl phthalate (DPP) produced significant decreases in testicular cytochrome P-450, cytochrome P-450 dependent microsomal steroidogenic enzymes (17 alpha-hydroxylase, 17-20 lyase) and in the maximal binding of a natural substrate (progesterone) to testis microsomes [5].
Hamsters showed no testicular changes with DBP and only minor changes in response to di-(2-ethylhexyl)phthalate (DEHP) and di-n-pentylphthalate (DPP) [6].
Androgen binding protein (ABP), produced by Sertoli cells and released into seminiferous tubules and blood, was measured in the serum of di-n-pentyl phthalate (DPP)-treated rats as a potential index of germinal epithelial damage [7].

References

The morphological development of di-N-pentyl phthalate induced testicular atrophy in the rat. Creasy, D.M., Foster, J.R., Foster, P.M. J. Pathol. (1983) [Pubmed]
Accelerated degradation of dipentyl phthalate by Fusarium oxysporum f. sp. pisi cutinase and toxicity evaluation of its degradation products using bioluminescent bacteria. Ahn, J.Y., Kim, Y.H., Min, J., Lee, J. Curr. Microbiol. (2006) [Pubmed]
Changes in ultrastructure and cytochemical localization of zinc in rat testis following the administration of di-n-pentyl phthalate. Foster, P.M., Foster, J.R., Cook, M.W., Thomas, L.V., Gangolli, S.D. Toxicol. Appl. Pharmacol. (1982) [Pubmed]
Suppression by phthalates of the calcium signaling of human nicotinic acetylcholine receptors in human neuroblastoma SH-SY5Y cells. Lu, K.Y., Tseng, F.W., Wu, C.J., Liu, P.S. Toxicology (2004) [Pubmed]
Effect of DI-n-pentyl phthalate treatment on testicular steroidogenic enzymes and cytochrome P-450 in the rat. Foster, P.M., Thomas, L.V., Cook, M.W., Walters, D.G. Toxicol. Lett. (1983) [Pubmed]
Species differences in the testicular toxicity of phthalate esters. Gray, T.J., Rowland, I.R., Foster, P.M., Gangolli, S.D. Toxicol. Lett. (1982) [Pubmed]
Comparison of changes in serum androgen binding protein with germinal epithelial damage and infertility induced by di-n-pentyl phthalate. Lindström, P., Harris, M., Ross, M., Lamb, J.C., Chapin, R.E. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1988) [Pubmed]

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