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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

SureCN1333     3-phenylprop-2-enoic acid

Synonyms: AGN-PC-0069LP, AG-B-74462, AG-K-93351, ANW-20546, KB-76099, ...
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Disease relevance of cinnamic acid

  • The EC50 values for CG and BCG on lettuce were roughly one-half to one-quarter of the value for cis-ABA. cis-Cinnamic acid, which is a component of CG and BCG, possessed almost the same inhibitory activity of CG and BCG, suggesting that the essential chemical structure responsible for the inhibitory activity of CG and BCG is cis-CA [1].
  • These results strongly indicate the potential therapeutic use of these compounds for the treatment of colonic inflammation with a lower risk of hemorrhage when compared with mammalian heparin [2].

Associations of cinnamic acid with other chemical compounds


Gene context of cinnamic acid

  • These studies suggest that the clinical heterogeneity in the HIT immune response may be due in part to requirements for specific biophysical parameters of the PF4/heparin complexes that occur in settings of intense platelet activation and PF4 release [7].
  • Mutations that affect the heparin binding activity also led to an unexpected reduction in the affinity of VEGF164 binding specifically to VEGFR1 [8].
  • We found that heparin binds PCI in a linear fashion along helix H to bridge thrombin, consistent with our recent crystal structure (3B9F), but that it must rotate by approximately 60 degrees to engage Arg-229 to bridge APC [9].


  1. Plant growth inhibition by cis-cinnamoyl glucosides and cis-cinnamic acid. Hiradate, S., Morita, S., Furubayashi, A., Fujii, Y., Harada, J. J. Chem. Ecol. (2005) [Pubmed]
  2. Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats. Belmiro, C.L., Castelo-Branco, M.T., Melim, L.M., Schanaider, A., Elia, C., Madi, K., Pavão, M.S., de Souza, H.S. J. Biol. Chem. (2009) [Pubmed]
  3. Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions. Lerch, T.F., Shimasaki, S., Woodruff, T.K., Jardetzky, T.S. J. Biol. Chem. (2007) [Pubmed]
  4. Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin. Vorup-Jensen, T., Chi, L., Gjelstrup, L.C., Jensen, U.B., Jewett, C.A., Xie, C., Shimaoka, M., Linhardt, R.J., Springer, T.A. J. Biol. Chem. (2007) [Pubmed]
  5. Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation. Bax, D.V., Mahalingam, Y., Cain, S., Mellody, K., Freeman, L., Younger, K., Shuttleworth, C.A., Humphries, M.J., Couchman, J.R., Kielty, C.M. J. Cell. Sci. (2007) [Pubmed]
  6. Intravenous lipid and heparin infusion-induced elevation in free fatty acids and triglycerides modifies circulating androgen levels in women: a randomized, controlled trial. Mai, K., Bobbert, T., Reinecke, F., Andres, J., Maser-Gluth, C., Wudy, S.A., Möhlig, M., Weickert, M.O., Hartmann, M.F., Schulte, H.M., Diederich, S., Pfeiffer, A.F., Spranger, J. J. Clin. Endocrinol. Metab. (2008) [Pubmed]
  7. Determinants of PF4/heparin immunogenicity. Suvarna, S., Espinasse, B., Qi, R., Lubica, R., Poncz, M., Cines, D.B., Wiesner, M.R., Arepally, G.M. Blood (2007) [Pubmed]
  8. Molecular mapping and functional characterization of the VEGF164 heparin-binding domain. Krilleke, D., DeErkenez, A., Schubert, W., Giri, I., Robinson, G.S., Ng, Y.S., Shima, D.T. J. Biol. Chem. (2007) [Pubmed]
  9. The heparin binding site of protein C inhibitor is protease-dependent. Li, W., Huntington, J.A. J. Biol. Chem. (2008) [Pubmed]
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