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Gene Review

Vegfa  -  vascular endothelial growth factor A

Mus musculus

Synonyms: VEGF-A, VEGF120, VEGF164, VEGF188, VPF, ...
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Disease relevance of Vegfa


High impact information on Vegfa


Chemical compound and disease context of Vegfa


Biological context of Vegfa


Anatomical context of Vegfa


Associations of Vegfa with chemical compounds


Physical interactions of Vegfa

  • In contrast, VEGF-A binds VEGFR1 and VEGFR2 and is an essential hemangiogenic factor [23].
  • Nrp-1 also binds the VEGF-A splice isoform VEGF165, stimulates angiogenesis, and is necessary for vascular development in the mouse [24].

Regulatory relationships of Vegfa


Other interactions of Vegfa


Analytical, diagnostic and therapeutic context of Vegfa


  1. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Lambrechts, D., Storkebaum, E., Morimoto, M., Del-Favero, J., Desmet, F., Marklund, S.L., Wyns, S., Thijs, V., Andersson, J., van Marion, I., Al-Chalabi, A., Bornes, S., Musson, R., Hansen, V., Beckman, L., Adolfsson, R., Pall, H.S., Prats, H., Vermeire, S., Rutgeerts, P., Katayama, S., Awata, T., Leigh, N., Lang-Lazdunski, L., Dewerchin, M., Shaw, C., Moons, L., Vlietinck, R., Morrison, K.E., Robberecht, W., Van Broeckhoven, C., Collen, D., Andersen, P.M., Carmeliet, P. Nat. Genet. (2003) [Pubmed]
  2. The vascular endothelial growth factor receptor KDR/Flk-1 is a major regulator of malignant ascites formation in the mouse hepatocellular carcinoma model. Yoshiji, H., Kuriyama, S., Hicklin, D.J., Huber, J., Yoshii, J., Ikenaka, Y., Noguchi, R., Nakatani, T., Tsujinoue, H., Fukui, H. Hepatology (2001) [Pubmed]
  3. Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha. Yuan, H.T., Li, X.Z., Pitera, J.E., Long, D.A., Woolf, A.S. Am. J. Pathol. (2003) [Pubmed]
  4. Tetralogy of fallot and alterations in vascular endothelial growth factor-A signaling and notch signaling in mouse embryos solely expressing the VEGF120 isoform. van den Akker, N.M., Molin, D.G., Peters, P.P., Maas, S., Wisse, L.J., van Brempt, R., van Munsteren, C.J., Bartelings, M.M., Poelmann, R.E., Carmeliet, P., Gittenberger-de Groot, A.C. Circ. Res. (2007) [Pubmed]
  5. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., Van Dorpe, J., Hellings, P., Gorselink, M., Heymans, S., Theilmeier, G., Dewerchin, M., Laudenbach, V., Vermylen, P., Raat, H., Acker, T., Vleminckx, V., Van Den Bosch, L., Cashman, N., Fujisawa, H., Drost, M.R., Sciot, R., Bruyninckx, F., Hicklin, D.J., Ince, C., Gressens, P., Lupu, F., Plate, K.H., Robberecht, W., Herbert, J.M., Collen, D., Carmeliet, P. Nat. Genet. (2001) [Pubmed]
  6. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Tam, B.Y., Wei, K., Rudge, J.S., Hoffman, J., Holash, J., Park, S.K., Yuan, J., Hefner, C., Chartier, C., Lee, J.S., Jiang, S., Niyak, N.R., Kuypers, F.A., Ma, L., Sundram, U., Wu, G., Garcia, J.A., Schrier, S.L., Maher, J.J., Johnson, R.S., Yancopoulos, G.D., Mulligan, R.C., Kuo, C.J. Nat. Med. (2006) [Pubmed]
  7. Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A. Conejo-Garcia, J.R., Benencia, F., Courreges, M.C., Kang, E., Mohamed-Hadley, A., Buckanovich, R.J., Holtz, D.O., Jenkins, A., Na, H., Zhang, L., Wagner, D.S., Katsaros, D., Caroll, R., Coukos, G. Nat. Med. (2004) [Pubmed]
  8. Dopaminergic D2 receptor knockout mouse: an animal model of prolactinoma. Cristina, C., García-Tornadú, I., Díaz-Torga, G., Rubinstein, M., Low, M.J., Becú-Villalobos, D. Frontiers of hormone research. (2006) [Pubmed]
  9. Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation. Yano, S., Herbst, R.S., Shinohara, H., Knighton, B., Bucana, C.D., Killion, J.J., Wood, J., Fidler, I.J. Clin. Cancer Res. (2000) [Pubmed]
  10. The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation. Ning, S., Laird, D., Cherrington, J.M., Knox, S.J. Radiat. Res. (2002) [Pubmed]
  11. VEGFA is necessary for chondrocyte survival during bone development. Zelzer, E., Mamluk, R., Ferrara, N., Johnson, R.S., Schipani, E., Olsen, B.R. Development (2004) [Pubmed]
  12. Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors. Walczak, R., Joseph, S.B., Laffitte, B.A., Castrillo, A., Pei, L., Tontonoz, P. J. Biol. Chem. (2004) [Pubmed]
  13. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Bellomo, D., Headrick, J.P., Silins, G.U., Paterson, C.A., Thomas, P.S., Gartside, M., Mould, A., Cahill, M.M., Tonks, I.D., Grimmond, S.M., Townson, S., Wells, C., Little, M., Cummings, M.C., Hayward, N.K., Kay, G.F. Circ. Res. (2000) [Pubmed]
  14. A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels. Hallaq, H., Pinter, E., Enciso, J., McGrath, J., Zeiss, C., Brueckner, M., Madri, J., Jacobs, H.C., Wilson, C.M., Vasavada, H., Jiang, X., Bogue, C.W. Development (2004) [Pubmed]
  15. Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Covassin, L.D., Villefranc, J.A., Kacergis, M.C., Weinstein, B.M., Lawson, N.D. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  16. Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells. Suzuki, H., Watabe, T., Kato, M., Miyazawa, K., Miyazono, K. Blood (2005) [Pubmed]
  17. Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A. Kadambi, A., Mouta Carreira, C., Yun, C.O., Padera, T.P., Dolmans, D.E., Carmeliet, P., Fukumura, D., Jain, R.K. Cancer Res. (2001) [Pubmed]
  18. Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2. Enciso, J.M., Gratzinger, D., Camenisch, T.D., Canosa, S., Pinter, E., Madri, J.A. J. Cell Biol. (2003) [Pubmed]
  19. Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation. Kwak, H.J., Park, M.J., Park, C.M., Moon, S.I., Yoo, D.H., Lee, H.C., Lee, S.H., Kim, M.S., Lee, H.W., Shin, W.S., Park, I.C., Rhee, C.H., Hong, S.I. Int. J. Cancer (2006) [Pubmed]
  20. Comparative effects of early postnatal ibuprofen and indomethacin on VEGF, IGF-I, and GH during rat ocular development. Beharry, K.D., Modanlou, H.D., Hasan, J., Gharraee, Z., Abad-Santos, P., Sills, J.H., Jan, A., Nageotte, S., Aranda, J.V. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  21. Tie2 activation contributes to hemangiogenic regeneration after myelosuppression. Kopp, H.G., Avecilla, S.T., Hooper, A.T., Shmelkov, S.V., Ramos, C.A., Zhang, F., Rafii, S. Blood (2005) [Pubmed]
  22. Dopamine in vivo inhibits VEGF-induced phosphorylation of VEGFR-2, MAPK, and focal adhesion kinase in endothelial cells. Sarkar, C., Chakroborty, D., Mitra, R.B., Banerjee, S., Dasgupta, P.S., Basu, S. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  23. VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. Cursiefen, C., Chen, L., Borges, L.P., Jackson, D., Cao, J., Radziejewski, C., D'Amore, P.A., Dana, M.R., Wiegand, S.J., Streilein, J.W. J. Clin. Invest. (2004) [Pubmed]
  24. Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system. Gerhardt, H., Ruhrberg, C., Abramsson, A., Fujisawa, H., Shima, D., Betsholtz, C. Dev. Dyn. (2004) [Pubmed]
  25. Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts. Yen, M.L., Su, J.L., Chien, C.L., Tseng, K.W., Yang, C.Y., Chen, W.F., Chang, C.C., Kuo, M.L. Mol. Pharmacol. (2005) [Pubmed]
  26. Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Deckers, M.M., van Bezooijen, R.L., van der Horst, G., Hoogendam, J., van Der Bent, C., Papapoulos, S.E., Löwik, C.W. Endocrinology (2002) [Pubmed]
  27. Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP. Guan, F., Villegas, G., Teichman, J., Mundel, P., Tufro, A. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  28. Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos. Hiratsuka, S., Kataoka, Y., Nakao, K., Nakamura, K., Morikawa, S., Tanaka, S., Katsuki, M., Maru, Y., Shibuya, M. Mol. Cell. Biol. (2005) [Pubmed]
  29. Vascular endothelial growth factor-A, vascular endothelial growth factor receptor-2 and angiopoietin-2 expression in the mouse choroid plexuses. Nico, B., Mangieri, D., Corsi, P., De Giorgis, M., Vacca, A., Roncali, L., Ribatti, D. Brain Res. (2004) [Pubmed]
  30. Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Gao, X., Chen, X., Taglienti, M., Rumballe, B., Little, M.H., Kreidberg, J.A. Development (2005) [Pubmed]
  31. Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro. Mould, A.W., Greco, S.A., Cahill, M.M., Tonks, I.D., Bellomo, D., Patterson, C., Zournazi, A., Nash, A., Scotney, P., Hayward, N.K., Kay, G.F. Circ. Res. (2005) [Pubmed]
  32. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. Eremina, V., Sood, M., Haigh, J., Nagy, A., Lajoie, G., Ferrara, N., Gerber, H.P., Kikkawa, Y., Miner, J.H., Quaggin, S.E. J. Clin. Invest. (2003) [Pubmed]
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