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Chemical Compound Review:

Khladon 125 1,1,1,2,2-pentafluoroethane

Synonyms: HFC-125, AGN-PC-0CR9A1, Fron 125, HCFC 125, CCRIS 7630, ...

Kawano, T. et al., Gjølstad, M. et al.

Gjølstad, Ellingsen, Espeland, Nordby, Evenseth, Thorud, Skaugset, Thomassen,

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Disease relevance of Fron 125

HFC-125 was not mutagenic in Salmonella typhimurium and Escherichia coli strains at concentrations of 20 to 100% (v/v) with and without activation [1].
Acute, subacute, and subchronic inhalation toxicity studies, developmental toxicity studies, a cardiac sensitization evaluation, and mutagenicity assays were conducted with pentafluoroethane (HFC-125) [1].

High impact information on Fron 125

This study describes refrigeration repair workers' occupational exposures to halogenated refrigerants, focusing on difluorochloromethane (HCFC 22), tetrafluoroethane (HFC 134a) and a mixture of tri-, tetra- and pentafluoroethane (R404A) in 30 work operations [2].
However, a statistically significant increase in chromosomally aberrant cells was observed in CHO cells at 60% HFC-125 when treatment without activation was extended to 48 hr [1].
In vivo, no micronuclei were induced in mouse bone marrow at concentrations as high as 600,000 ppm HFC-125 for a 6-hr exposure [1].

References

Toxicological evaluation of 1,1,1,2,2-pentafluoroethane (HFC-125). Kawano, T., Trochimowicz, H.J., Malinverno, G., Rusch, G.M. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1995) [Pubmed]
Occupational exposure to fluorinated hydrocarbons during refrigeration repair work. Gjølstad, M., Ellingsen, D.G., Espeland, O., Nordby, K.C., Evenseth, H., Thorud, S., Skaugset, N.P., Thomassen, Y. Journal of environmental monitoring : JEM. (2003) [Pubmed]

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