Disease relevance of Pantoic lactone

• The pantothenase from an old strain, Pseudomonas fluorescens UK-1, was shown to produce beta-alanine and pantoyl lactone [1].
• Modification of cell membrane lipids in Micrococcus lysodeikticus induced by pantoyl lactone [2].
• In contrast to pantolactone, which inhibited thermal induction of cell filament formation and lambda prophage in the tif mutant as previously described, butyrolactone enhanced these phenomena [3].
• The effects of postirradiation incubation with various chemicals structurally related to pantolactone on the survival of ultraviolet-irradiated Escherichia coli lon and ruv mutants were examined [4].

High impact information on Pantoic lactone

• The esterase-catalyzed enantioselective hydrolysis of the fluoroacetate of pantolactone leads to fluoroacetic acid, a toxic compound which inhibits the growth of esterase-producing yeast; this forms the basis of an ee-assay [5].
• An effective synthesis of the C1-C10 component of deoxyfusapyrone has been achieved that will allow for the synthesis of both the (R) and (S) form of the C-8 chiral center starting from optically pure (+)- and (-)-3,3-dimethyl-2-hydroxy-gammalactone (pantolactone) [6].
• Analysis of stereochemistry of enzymically formed pantoyl lactone or pantoic acid by gas chromatography and circular dichroism [7].
• Growth of the organism in the presence of D-cycloserine and pantoyl lactone prevents the leakage of membrne components and cell division inhibition [8].

Anatomical context of Pantoic lactone

• Growth of Microccoccus lysodeikticus in the presence of pantoyl lactone brings about both qualitative and quantitative changes in cell membrane lipids [2].

Analytical, diagnostic and therapeutic context of Pantoic lactone

• Separation and determination of the enantiomers of pantolactone by gas-liquid chromatography [9].

References