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Chemical Compound Review

Fluoroacetate     2-fluoroethanoate

Synonyms: Cymoric acid, AG-F-73736, CHEBI:18172, CPD-12709, FCH2CO2 anion, ...
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Disease relevance of Monofluoressigsaures natrium


Psychiatry related information on Monofluoressigsaures natrium


High impact information on Monofluoressigsaures natrium


Chemical compound and disease context of Monofluoressigsaures natrium


Biological context of Monofluoressigsaures natrium


Anatomical context of Monofluoressigsaures natrium

  • Since both fluoroacetate and MSO act exclusively on glial cells, the findings also show that neuronal-glial interactions are necessary during the establishment of memory [21].
  • Four strains of Butyrivibrio fibrisolvens, transformed with a gene encoding fluoroacetate dehalogenase, maintained a combined population of 10(6) to 10(7) cells ml-1 in the rumens of test sheep [22].
  • Fluoroacetate is known to block cell metabolism and to change potassium conductances selectively in astrocytes [23].
  • Effects of fluoroacetate on the testis of the rat [24].
  • (v) The lack of significant [14C]ACh synthesis from [1-14C]acetate in striatal synaptosomes is consistent with the failure of fluoroacetate to modify the amounts of 14CO2 as well as of [14C]ACh formed from [2-14C]pyruvate [25].

Associations of Monofluoressigsaures natrium with other chemical compounds


Gene context of Monofluoressigsaures natrium

  • The Moraxella sp. strain B gene dehH1, encoding fluoroacetate dehalogenase, was placed under the control of both the GPD1 and CYC1 promoters [30].
  • Selective metabolic impairment of glial cells with fluoroacetate decreased ERK activation [31].
  • Fluoroacetate-resistant mutants were isolated and four different classes were identified: ack, lacking acetate kinase; pta, lacking phosphotransacetylase; facA, lacking both of these activities; and facB, which retained both of these enzyme activities [32].
  • The evidence suggests that GSTZ1 may not be the major enzyme defluorinating fluoroacetate, but it does detoxify the fluoroacetate [33].
  • Administration of fluoroacetate, a competitive inhibitor of aconitase activity, resulted in a dose-dependent decrease in the life span of the flies [34].

Analytical, diagnostic and therapeutic context of Monofluoressigsaures natrium


  1. Reaction mechanism of fluoroacetate dehalogenase from Moraxella sp. B. Liu, J.Q., Kurihara, T., Ichiyama, S., Miyagi, M., Tsunasawa, S., Kawasaki, H., Soda, K., Esaki, N. J. Biol. Chem. (1998) [Pubmed]
  2. Assay for the enantiomeric analysis of [2H1]-fluoroacetic acid: insight into the stereochemical course of fluorination during fluorometabolite biosynthesis in streptomyces cattleya. O'Hagan, D., Goss, R.J., Meddour, A., Courtieu, J. J. Am. Chem. Soc. (2003) [Pubmed]
  3. Engineering gut flora of ruminant livestock to reduce forage toxicity: progress and problems. Gregg, K. Trends Biotechnol. (1995) [Pubmed]
  4. Fluoroacetate-metabolizing pseudomonad isolated from Dichapetalum cymosum. Meyer, J.J., Grobbelaar, N., Steyn, P.L. Appl. Environ. Microbiol. (1990) [Pubmed]
  5. Isolation and characterization of ack and pta mutations in Azotobacter vinelandii affecting acetate-glucose diauxie. McKenney, D., Melton, T. J. Bacteriol. (1986) [Pubmed]
  6. Fluoroacetate-mediated toxicity of fluorinated ethanes. Keller, D.A., Roe, D.C., Lieder, P.H. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1996) [Pubmed]
  7. Metabolic control of circulation. Effects of iodoacetate and fluoroacetate. Liang, C.S. J. Clin. Invest. (1977) [Pubmed]
  8. Stimulation of ammonia production and excretion in the rabbit by inorganic phosphate. Study of control mechanisms. Yu, H.L., Giammarco, R., Goldstein, M.B., Stinebaugh, D.J., Halperin, M.L. J. Clin. Invest. (1976) [Pubmed]
  9. Characterization of Arabidopsis fluoroacetate-resistant mutants reveals the principal mechanism of acetate activation for entry into the glyoxylate cycle. Turner, J.E., Greville, K., Murphy, E.C., Hooks, M.A. J. Biol. Chem. (2005) [Pubmed]
  10. Purification of a fluoroacetate-specific defluorinase from mouse liver cytosol. Soiefer, A.I., Kostyniak, P.J. J. Biol. Chem. (1984) [Pubmed]
  11. Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya. Murphy, C.D., Moss, S.J., O'Hagan, D. Appl. Environ. Microbiol. (2001) [Pubmed]
  12. Clostridium thermosaccharolyticum strain deficient in acetate production. Rothstein, D.M. J. Bacteriol. (1986) [Pubmed]
  13. Fluorinated probes to measure carboxylesterase activities using 19F NMR spectroscopy: application to erythrocytes and Helicobacter pylori. Mendz, G.L., Lim, T.N., Hazell, S.L. Arch. Biochem. Biophys. (1993) [Pubmed]
  14. Substrate supply and function of isolated venous smooth muscle under anoxia and metabolic inhibition. Cremer-Lacuara, M.G., Lacuara, J.L., Fiol de Cuneo, M., Ruiz, R.D. Can. J. Physiol. Pharmacol. (1980) [Pubmed]
  15. Toxicity of a fatty acid and ammonia: interactions with hypoglycemia and Krebs cycle inhibition. Zieve, L., Lyftogt, C., Draves, K. J. Lab. Clin. Med. (1983) [Pubmed]
  16. Isolation of 2-fluorocitrate produced by in vivo dealkylation of 29-fluorostigmasterol in an insect. Prestwich, G.D., Yamaoka, R., Phirwa, S., DePalma, A. J. Biol. Chem. (1984) [Pubmed]
  17. Regional differences in glial cell modulation of synaptic transmission. Keyser, D.O., Pellmar, T.C. Hippocampus. (1997) [Pubmed]
  18. Synaptic transmission in the hippocampus: critical role for glial cells. Keyser, D.O., Pellmar, T.C. Glia (1994) [Pubmed]
  19. Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-alpha-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain. O'Donnell, V.B., Spycher, S., Azzi, A. Biochem. J. (1995) [Pubmed]
  20. Metabolic coupling between glia and neurons is necessary for maintaining respiratory activity in transverse medullary slices of neonatal mouse. Hülsmann, S., Oku, Y., Zhang, W., Richter, D.W. Eur. J. Neurosci. (2000) [Pubmed]
  21. Complex roles of glutamate in the Gibbs-Ng model of one-trial aversive learning in the new-born chick. Ng, K.T., O'Dowd, B.S., Rickard, N.S., Robinson, S.R., Gibbs, M.E., Rainey, C., Zhao, W.Q., Sedman, G.L., Hertz, L. Neuroscience and biobehavioral reviews. (1997) [Pubmed]
  22. Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning. Gregg, K., Hamdorf, B., Henderson, K., Kopecny, J., Wong, C. Appl. Environ. Microbiol. (1998) [Pubmed]
  23. Blockade of astrocyte metabolism causes delayed excitation as revealed by voltage-sensitive dyes in mouse brainstem slices. Hülsmann, S., Straub, H., Richter, D.W., Speckmann, E.J. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2003) [Pubmed]
  24. Effects of fluoroacetate on the testis of the rat. Sullivan, J.L., Smith, F.A., Garman, R.H. J. Reprod. Fertil. (1979) [Pubmed]
  25. Origin of the acetyl moiety of acetylcholine synthesized in rat striatal synaptosomes. Lefresne, P., Hamon, M., Beaujouan, J.C., Glowinski, J. Biochimie (1977) [Pubmed]
  26. Enzymatic defluorination and metabolism of fluoroacetate, fluoroacetamide, fluoroethanol, and (-)-erythro-fluorocitrate in rats and mice examined by 19F and 13C NMR. Tecle, B., Casida, J.E. Chem. Res. Toxicol. (1989) [Pubmed]
  27. Synthesis of fluoroacetate from fluoride, glycerol, and beta-hydroxypyruvate by Streptomyces cattleya. Tamura, T., Wada, M., Esaki, N., Soda, K. J. Bacteriol. (1995) [Pubmed]
  28. Stimulation by aminooxyacetate of fluorescein uptake in rat renal tubules in vitro: role of intracellular alpha-ketoglutarate. Nikiforov, A.A. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  29. The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate. Arellano, M., Malet-Martino, M., Martino, R., Gires, P. Br. J. Cancer (1998) [Pubmed]
  30. Expression cassettes for formaldehyde and fluoroacetate resistance, two dominant markers in Saccharomyces cerevisiae. van den Berg, M.A., Steensma, H.Y. Yeast (1997) [Pubmed]
  31. Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutathione depletion in neuron/glia mesencephalic cultures. de Bernardo, S., Canals, S., Casarejos, M.J., Solano, R.M., Menendez, J., Mena, M.A. J. Neurochem. (2004) [Pubmed]
  32. Anaerobic growth of Escherichia coli K12 with fumarate as terminal electron acceptor. Genetic studies with menaquinone and fluoroacetate-resistant mutants. Guest, J.R. J. Gen. Microbiol. (1979) [Pubmed]
  33. Is fluoroacetate-specific defluorinase a glutathione S-transferase? Tu, L.Q., Wright, P.F., Rix, C.J., Ahokas, J.T. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2006) [Pubmed]
  34. Selectivity of protein oxidative damage during aging in Drosophila melanogaster. Das, N., Levine, R.L., Orr, W.C., Sohal, R.S. Biochem. J. (2001) [Pubmed]
  35. Fluoroacetate content of some species of the toxic Australian plant genus, Gastrolobium, and its environmental persistence. Twigg, L.E., King, D.R., Bowen, L.H., Wright, G.R., Eason, C.T. Nat. Toxins (1996) [Pubmed]
  36. Astrocytes and the entry of circulating ammonia into the brain: effect of fluoroacetate. Szerb, J.C., Redondo, I.M. Metabolic brain disease. (1993) [Pubmed]
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