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Chemical Compound Review

beta-alanine     3-aminopropanoic acid

Synonyms: Abufene, BALA, beta-Ala, B-ALANINE, ss-Ala, ...
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Disease relevance of beta-alanine


High impact information on beta-alanine

  • Whereas wild-type alpha 1 channels expressed in Xenopus oocytes required 0.7 millimolar beta-alanine for a half-maximal response, the doubly mutated (F159Y,Y161F) alpha 1 subunit had an affinity for beta-alanine (which was more potent than glycine) that was 110-fold that of the wild type [6].
  • A conjugate containing a beta-alanine residue at the C terminus of the polyamide moiety showed no nuclear localization, whereas an analogous compound lacking the beta-alanine residue was strongly localized in the nuclei of all cell lines tested [7].
  • However, the calculated isoelectric point of the taurine/beta-alanine transporter is more acidic (pI = 5.98) than those (pI > 8.0) of other cloned neurotransmitter transporters [8].
  • At this survival time, 61% of the radioactivity in the olfactory epithelium was present in the carnosine fraction, while 37% of the label remained in the beta-alanine fraction [9].
  • From these results, we concluded that TGR7 functioned as a specific membrane receptor for beta-alanine [10].

Chemical compound and disease context of beta-alanine


Biological context of beta-alanine

  • These results indicate that harmaline does not compete with sodium for a binding site on the carrier as has been suggested for other sodium-coupled transport systems, and that instead, chloride may be required for harmaline binding to the beta-alanine transporter [16].
  • In this report, a combination of beta-alanine scanning mutagenesis and kinetic measurements was used to probe, in a quantitative, systematic, and simultaneous fashion, the relative contribution of the amino acid side chain and backbone functionalities to the overall calpain-inhibitory activity of B27-WT [17].
  • Recent studies in a variety of transport systems, including rat renal brush border membrane vesicles, indicate that halide anions chloride (Cl-) and bromide (Br-) are essential for glycine, beta-alanine, gamma-aminobutyric acid, and taurine uptake, so the possibility that Na(+)-proline symport is Cl- dependent was explored [18].
  • An LLC-PK1 cell line stably expressing GABA transporter type 3 (GAT-3), a beta-alanine-sensitive neuronal GABA transporter, has been generated and used to examine the kinetics, ion dependence, and pharmacological properties of the transporter [19].
  • The biosynthesis begins with the decarboxylation of aspartate to give beta-alanine [20].

Anatomical context of beta-alanine


Associations of beta-alanine with other chemical compounds


Gene context of beta-alanine


Analytical, diagnostic and therapeutic context of beta-alanine

  • Crude venom was fractionated by anion exchange and gel filtration in four steps. beta-Alanine acetate disk gel electrophoresis was used to demonstrate electrophoretic homogeneity [30].
  • However, the isomeric pairs could be resolved by reversed-phase high performance liquid chromatography, with the reverse amides having greater retention times compared to the beta-alanine conjugates [31].
  • Growth of SJ16/pKAS4 on [3H]-beta-alanine followed by Coomassie staining of the protein and autoradiography revealed that PHA synthase is overexpressed and that beta-alanine is incorporated into the protein [32].
  • The reverse amide analogs comigrated with their isomeric beta-alanine conjugates during thin-layer chromatography using a variety of solvent systems [31].
  • Two synthetic analogues of distamycin (Dst), PPA and PAP, containing a saturated beta-alanine moiety substituting for an N-methylpyrrole chromophore were studied for their interactions with the double-stranded alternating copolymer poly(dA-dT).poly(dA-dt) [abbreviated as poly(dA-dT)], with UV absorption and circular dichroism (CD) spectroscopy [33].


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  17. Structural determinants of the calpain inhibitory activity of calpastatin peptide B27-WT. Betts, R., Weinsheimer, S., Blouse, G.E., Anagli, J. J. Biol. Chem. (2003) [Pubmed]
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  22. Pyridoxine-responsive hyper-beta-alaninemia associated with Cohen's syndrome. Higgins, J.J., Kaneski, C.R., Bernardini, I., Brady, R.O., Barton, N.W. Neurology (1994) [Pubmed]
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