The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

SSH1  -  slingshot protein phosphatase 1

Homo sapiens

Synonyms: KIAA1298, Protein phosphatase Slingshot homolog 1, SSH-1L, SSH-like protein 1, SSH1L, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on SSH1

  • We also show that the phosphatase activity of purified SSH-1L is F-actin dependent and is negatively regulated via phosphorylation by PAK4 [1].
  • Endogenous LIMK1 and SSH-1L interact in vitro and co-localize in vivo, and this interaction results in dephosphorylation and downregulation of LIMK1 activity [1].
  • Here, we show that cofilin-phosphatase activity of SSH1L increases approximately 10-fold by association with actin filaments, which indicates that actin assembly at the leading edge per se triggers local activation of SSH1L and thereby stimulates cofilin-mediated actin turnover in lamellipodia [2].
  • These findings suggest that SSH1L is locally activated by translocation to and association with F-actin in lamellipodia in response to neuregulin-1beta and 14-3-3 proteins negatively regulate SSH1L activity by sequestering it in the cytoplasm [2].
  • Finally, suppression of SSH1L expression by RNA interference abolished insulin-induced cofilin dephosphorylation and the membrane protrusion [3].
 

Biological context of SSH1

  • Expression of a phosphatase-inactive SSH1 induces aberrant accumulation of F-actin and phospho-cofilin near the midbody in the final stage of cytokinesis and frequently leads to the regression of the cleavage furrow and the formation of multinucleate cells [4].
  • These results suggest that SSH1 plays a critical role in cytokinesis by dephosphorylating and reactivating cofilin in later stages of mitosis [4].
  • Here we show that the phosphatase activity of SSH1 decreases in the early stages of mitosis and is elevated in telophase and cytokinesis in HeLa cells, a time course correlating with that of cofilin dephosphorylation [4].
  • Upon screening 30 candidate genes, we identified a missense mutation, p.Ser63Asn in SSH1 in one family, a frameshift mutation, p.Ser19CysfsX24 in an alternative variant (isoform f) of SSH1 in another family, and a frameshift mutation, p.Pro27ProfsX54 in the same alternative variant in one non-familial case with DSAP [5].
 

Anatomical context of SSH1

  • Overexpression of SSH1 does not mimic the neurite outgrowth inhibitory effects of myelin, suggesting an alternative role in MAI inhibition [6].
  • Here we show that insulin stimulates the phosphatase activity of Slingshot-1L (SSH1L) and cofilin dephosphorylation in cultured cells, in a manner dependent on phosphoinositide 3-kinase (PI3K) activity [3].
  • SSH-1L and SSH-2L, but not SSH-3L, tightly bound to and co-localized with actin filaments [7].
  • CONCLUSION: Both SSH1 and ARPC3 are involved in the actin cytoskeleton pathway and interacted with adherent junctions in the epidermal cells [8].
  • Stimulation of cells with neuregulin-1beta induced Ser-978 dephosphorylation, translocation of SSH1L onto F-actin-rich lamellipodia, and cofilin dephosphorylation [2].
 

Associations of SSH1 with chemical compounds

 

Other interactions of SSH1

References

  1. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. Soosairajah, J., Maiti, S., Wiggan, O., Sarmiere, P., Moussi, N., Sarcevic, B., Sampath, R., Bamburg, J.R., Bernard, O. EMBO J. (2005) [Pubmed]
  2. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. Nagata-Ohashi, K., Ohta, Y., Goto, K., Chiba, S., Mori, R., Nishita, M., Ohashi, K., Kousaka, K., Iwamatsu, A., Niwa, R., Uemura, T., Mizuno, K. J. Cell Biol. (2004) [Pubmed]
  3. Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. Nishita, M., Wang, Y., Tomizawa, C., Suzuki, A., Niwa, R., Uemura, T., Mizuno, K. J. Biol. Chem. (2004) [Pubmed]
  4. Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. Kaji, N., Ohashi, K., Shuin, M., Niwa, R., Uemura, T., Mizuno, K. J. Biol. Chem. (2003) [Pubmed]
  5. Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis. Zhang, Z., Niu, Z., Yuan, W., Liu, W., Xiang, L., Zhang, J., Chu, X., Zhao, J., Jiang, F., Chai, B., Cui, F., Wang, Y., Zhang, K., Wang, Y., Xu, S., Xia, L., Gu, J., Zhang, S., Meng, X., Wang, S., Gao, S., Fan, M., Nie, L., Zheng, Z., Huang, W. Hum. Mutat. (2004) [Pubmed]
  6. Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase. Hsieh, S.H., Ferraro, G.B., Fournier, A.E. J. Neurosci. (2006) [Pubmed]
  7. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. Ohta, Y., Kousaka, K., Nagata-Ohashi, K., Ohashi, K., Muramoto, A., Shima, Y., Niwa, R., Uemura, T., Mizuno, K. Genes Cells (2003) [Pubmed]
  8. Two closely linked variations in actin cytoskeleton pathway in a Chinese pedigree with disseminated superficial actinic porokeratosis. Zhang, Z.H., Huang, W., Niu, Z.M., Liu, W.D., Xiang, L.H., Yuan, W.T., Zhao, J.J., Gu, C.Y., Chai, B., Jiang, F.X., Zhang, J., Xu, S.J., Zheng, Z.Z. J. Am. Acad. Dermatol. (2005) [Pubmed]
  9. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. Wang, Y., Shibasaki, F., Mizuno, K. J. Biol. Chem. (2005) [Pubmed]
 
WikiGenes - Universities