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Gene Review

Prkd2  -  protein kinase D2

Mus musculus

Synonyms: AI325941, PKD2, Serine/threonine-protein kinase D2, nPKC-D2
 
 
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Disease relevance of Prkd2

 

High impact information on Prkd2

  • Mutations of either PKD1 or PKD2 are associated with autosomal dominant polycystic kidney disease (ADPKD) [3].
  • We show that, when polycystin-1 is expressed alone in a PKD2 null cell line, it localizes to the cell surface, as well as to the endoplasmic reticulum [4].
  • Similar to those in aortas, de-endothelialized Pkd2(+/-) resistance (fourth-order mesenteric) arteries responded to PE with a stronger contraction but a lesser [Ca(2+)](i) rise than in wt [5].
  • Quantitative analyses of contractile proteins demonstrated elevated expressions in smooth muscle alpha-actin and myosin heavy chain in Pkd2(+/-) arteries, changes that likely contribute to the higher F(max) [5].
  • Ca(2+)-dependent calmodulin/myosin light-chain kinase-mediated contraction was examined by direct Ca(2+) (pCa8-5) stimulation to beta-escin permeabilized aortic strips; the pCa-force curve in Pkd2(+/-) strips was not shifted, thereby indicating that PE induced dosage-response alteration that resulted from Ca(2+)-independent mechanisms [5].
 

Biological context of Prkd2

  • Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells [6].
 

Anatomical context of Prkd2

 

Other interactions of Prkd2

  • Anomalous structure of primary cilia and/or impairment of increases in intracellular Ca2+ concentration in response to fluid flow are thought to result in renal cyst formation in conditional kif3a knockout, Tg737 and pkd1/pkd2 mutant mice [7].

References

  1. VEGF receptor 2 blockade leads to renal cyst formation in mice. McGrath-Morrow, S., Cho, C., Molls, R., Burne-Taney, M., Haas, M., Hicklin, D.J., Tuder, R., Rabb, H. Kidney Int. (2006) [Pubmed]
  2. Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head. Butscheid, Y., Chubanov, V., Steger, K., Meyer, D., Dietrich, A., Gudermann, T. Mol. Reprod. Dev. (2006) [Pubmed]
  3. Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Muto, S., Aiba, A., Saito, Y., Nakao, K., Nakamura, K., Tomita, K., Kitamura, T., Kurabayashi, M., Nagai, R., Higashihara, E., Harris, P.C., Katsuki, M., Horie, S. Hum. Mol. Genet. (2002) [Pubmed]
  4. Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells. Grimm, D.H., Cai, Y., Chauvet, V., Rajendran, V., Zeltner, R., Geng, L., Avner, E.D., Sweeney, W., Somlo, S., Caplan, M.J. J. Biol. Chem. (2003) [Pubmed]
  5. Pkd2+/- vascular smooth muscles develop exaggerated vasocontraction in response to phenylephrine stimulation. Qian, Q., Hunter, L.W., Du, H., Ren, Q., Han, Y., Sieck, G.C. J. Am. Soc. Nephrol. (2007) [Pubmed]
  6. Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells. Irie, A., Harada, K., Tsukamoto, H., Kim, J.R., Araki, N., Nishimura, Y. Int. Immunol. (2006) [Pubmed]
  7. Primary cilia of inv/inv mouse renal epithelial cells sense physiological fluid flow: bending of primary cilia and Ca2+ influx. Shiba, D., Takamatsu, T., Yokoyama, T. Cell Struct. Funct. (2005) [Pubmed]
 
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