Gene Review:
Ift88 - intraflagellar transport 88
Mus musculus
Synonyms:
AW552028, IFT88, Intraflagellar transport protein 88 homolog, Oak Ridge polycystic kidneys, Recessive polycystic kidney disease protein Tg737, ...
- Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells. Siroky, B.J., Ferguson, W.B., Fuson, A.L., Xie, Y., Fintha, A., Komlosi, P., Yoder, B.K., Schwiebert, E.M., Guay-Woodford, L.M., Bell, P.D. Am. J. Physiol. Renal Physiol. (2006)
- The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Murcia, N.S., Richards, W.G., Yoder, B.K., Mucenski, M.L., Dunlap, J.R., Woychik, R.P. Development (2000)
- The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance. Pazour, G.J., Baker, S.A., Deane, J.A., Cole, D.G., Dickert, B.L., Rosenbaum, J.L., Witman, G.B., Besharse, J.C. J. Cell Biol. (2002)
- The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms. Haycraft, C.J., Swoboda, P., Taulman, P.D., Thomas, J.H., Yoder, B.K. Development (2001)
- Oval cell proliferation associated with the murine insertional mutation TgN737Rpw. Richards, W.G., Yoder, B.K., Isfort, R.J., Detilleux, P.G., Foster, C., Neilsen, N., Woychik, R.P., Wilkinson, J.E. Am. J. Pathol. (1996)
- Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nauli, S.M., Alenghat, F.J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A.E., Lu, W., Brown, E.M., Quinn, S.J., Ingber, D.E., Zhou, J. Nat. Genet. (2003)
- Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. Pazour, G.J., Dickert, B.L., Vucica, Y., Seeley, E.S., Rosenbaum, J.L., Witman, G.B., Cole, D.G. J. Cell Biol. (2000)
- Cilia and Hedgehog responsiveness in the mouse. Huangfu, D., Anderson, K.V. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle. Morgan, D., Eley, L., Sayer, J., Strachan, T., Yates, L.M., Craighead, A.S., Goodship, J.A. Hum. Mol. Genet. (2002)
- Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Cano, D.A., Murcia, N.S., Pazour, G.J., Hebrok, M. Development (2004)
- Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Liu, A., Wang, B., Niswander, L.A. Development (2005)
- Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium. Yoder, B.K., Tousson, A., Millican, L., Wu, J.H., Bugg, C.E., Schafer, J.A., Balkovetz, D.F. Am. J. Physiol. Renal Physiol. (2002)
- Loss of the Tg737 protein results in skeletal patterning defects. Zhang, Q., Murcia, N.S., Chittenden, L.R., Richards, W.G., Michaud, E.J., Woychik, R.P., Yoder, B.K. Dev. Dyn. (2003)
- Expression of the orpk disease gene during kidney development and maturation. Nakanishi, K., Sweeney, W.E., Avner, E.D., Murcia, N.S. Pediatr. Nephrol. (2001)
- The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. Yoder, B.K., Hou, X., Guay-Woodford, L.M. J. Am. Soc. Nephrol. (2002)
- Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice. Zhang, Q., Davenport, J.R., Croyle, M.J., Haycraft, C.J., Yoder, B.K. Lab. Invest. (2005)
- Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia. Olteanu, D., Yoder, B.K., Liu, W., Croyle, M.J., Welty, E.A., Rosborough, K., Wyss, J.M., Bell, P.D., Guay-Woodford, L.M., Bevensee, M.O., Satlin, L.M., Schwiebert, E.M. Am. J. Physiol., Cell Physiol. (2006)
- Effect of polysaccharide extracted from Glaciecola polaris on the protection of mouse macrophages from oxidative injury. Qian, G., Xu, Z. Bioresour. Technol. (2007)
- Hedgehog signalling in the mouse requires intraflagellar transport proteins. Huangfu, D., Liu, A., Rakeman, A.S., Murcia, N.S., Niswander, L., Anderson, K.V. Nature (2003)
- Primary cilia of inv/inv mouse renal epithelial cells sense physiological fluid flow: bending of primary cilia and Ca2+ influx. Shiba, D., Takamatsu, T., Yokoyama, T. Cell Struct. Funct. (2005)
- Insertional mutagenesis and molecular analysis of a new gene associated with polycystic kidney disease. Yoder, B.K., Richards, W.G., Sweeney, W.E., Wilkinson, J.E., Avener, E.D., Woychik, R.P. Proc. Assoc. Am. Physicians (1995)
- Delayed cystogenesis and increased ciliogenesis associated with the re-expression of polaris in Tg737 mutant mice. Brown, N.E., Murcia, N.S. Kidney Int. (2003)