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Gene Review:

TRIM22 - tripartite motif containing 22

Homo sapiens

Synonyms: 50 kDa-stimulated trans-acting factor, E3 ubiquitin-protein ligase TRIM22, GPSTAF50, RING finger protein 94, RNF94, ...

Bouazzaoui, A. et al., Tissot, C. et al., Gongora, C. et al., Obad, S. et al., Tissot, C. et al.

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Disease relevance of TRIM22

Staf-50 is induced by both type I and type II IFN in various cell lines and down-regulates the transcription directed by the long terminal repeat promoter region of human immunodeficiency virus type 1 in transfected cells [1].
Stimulated trans-acting factor of 50 kDa (Staf50) inhibits HIV-1 replication in human monocyte-derived macrophages [2].

High impact information on TRIM22

Amino acid sequence analysis revealed that Staf-50 is a member of the Ring finger family and contains all the features of a transcriptional regulator able to initiate a second cascade of gene induction (secondary response) [1].
Moreover, levels of endogenous Staf50 mRNA correlated to all-trans retinoic acid-induced differentiation of promyelocytic NB-4 and HL60 cells, suggesting that Staf50 could be involved in proliferation and/or differentiation of leukemic cells [3].
Overexpression of Staf50 inhibited the HIV-1 infection between 50% and 90% in 293 T CD4/CCR5 as well as in MAC [2].
Using the microarray technology we identified a gene named Stimulated Trans-Acting Factor of 50 kDa (Staf50), which is known to repress the activity of the HIV-1 LTR [2].
Analysis of the Staf50 expression by real-time PCR showed an overexpression in IFNalpha (up to 20-fold) and LPS (up to 10-fold)-stimulated MAC as well as in infected cells (up to 3-fold) [2].

Anatomical context of TRIM22

We show in this report that Staf50 is expressed in resting T cells in the absence of exogenous IFN treatment and is strongly repressed during T cell activation by anti-CD28 and anti-CD2 monoclonal antibodies (mAb) at both messenger and protein levels [4].

Analytical, diagnostic and therapeutic context of TRIM22

Localization of Staf50, a member of the Ring finger family, to 11p15 by fluorescence in situ hybridization [5].

References

Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression. Tissot, C., Mechti, N. J. Biol. Chem. (1995) [Pubmed]
Stimulated trans-acting factor of 50 kDa (Staf50) inhibits HIV-1 replication in human monocyte-derived macrophages. Bouazzaoui, A., Kreutz, M., Eisert, V., Dinauer, N., Heinzelmann, A., Hallenberger, S., Strayle, J., Walker, R., R??bsamen-Waigmann, H., Andreesen, R., von Briesen, H. Virology (2006) [Pubmed]
Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells. Obad, S., Brunnström, H., Vallon-Christersson, J., Borg, A., Drott, K., Gullberg, U. Oncogene (2004) [Pubmed]
The interferon-inducible Staf50 gene is downregulated during T cell costimulation by CD2 and CD28. Gongora, C., Tissot, C., Cerdan, C., Mechti, N. J. Interferon Cytokine Res. (2000) [Pubmed]
Localization of Staf50, a member of the Ring finger family, to 11p15 by fluorescence in situ hybridization. Tissot, C., Taviaux, S.A., Diriong, S., Mechti, N. Genomics (1996) [Pubmed]

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